Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220932074> ?p ?o ?g. }
- W4220932074 endingPage "339761" @default.
- W4220932074 startingPage "339761" @default.
- W4220932074 abstract "Irinotecan (Iri) is a key drug to treat metastatic colorectal cancer, but its clinical activity is often limited by de novo and acquired drug resistance. Studying the underlying mechanisms of drug resistance is necessary for developing novel therapeutic strategies. In this study, we used both regular and irinotecan-resistant (Iri-resistant) colorectal cell lines as models, and performed single cell mass spectrometry (SCMS) metabolomics studies combined with analyses from cytotoxicity assay, western blot, flow cytometry, quantitative real-time polymerase chain reaction (qPCR), and reactive oxygen species (ROS). Our SCMS results indicate that Iri-resistant cancer cells possess higher levels of unsaturated lipids compared with the regular cancer cells. In addition, multiple protein biomarkers and their corresponding mRNAs of colon cancer stem cells are overexpressed in Iri-resistance cells. Particularly, stearoyl-CoA desaturase 1 (SCD1) is upregulated with the development of drug resistance in Iri-resistant cells, whereas inhibiting the activity of SCD1 efficiently increase their sensitivity to Iri treatment. In addition, we demonstrated that SCD1 directly regulates the expression of ALDH1A1, which contributes to the cancer stemness and ROS level in Iri-resistant cell lines." @default.
- W4220932074 created "2022-04-03" @default.
- W4220932074 creator A5001198001 @default.
- W4220932074 creator A5001477677 @default.
- W4220932074 creator A5028173227 @default.
- W4220932074 date "2022-05-01" @default.
- W4220932074 modified "2023-10-18" @default.
- W4220932074 title "Single cell mass spectrometry studies reveal metabolomic features and potential mechanisms of drug-resistant cancer cell lines" @default.
- W4220932074 cites W1458147944 @default.
- W4220932074 cites W1552667295 @default.
- W4220932074 cites W1771804721 @default.
- W4220932074 cites W1917896544 @default.
- W4220932074 cites W1980904258 @default.
- W4220932074 cites W1987586561 @default.
- W4220932074 cites W1989299822 @default.
- W4220932074 cites W1999223151 @default.
- W4220932074 cites W2020773529 @default.
- W4220932074 cites W2024587465 @default.
- W4220932074 cites W2035690311 @default.
- W4220932074 cites W2037679360 @default.
- W4220932074 cites W2041640316 @default.
- W4220932074 cites W2042670803 @default.
- W4220932074 cites W2044124957 @default.
- W4220932074 cites W2064553686 @default.
- W4220932074 cites W2066411725 @default.
- W4220932074 cites W2066527389 @default.
- W4220932074 cites W2070706554 @default.
- W4220932074 cites W2070954950 @default.
- W4220932074 cites W2071368017 @default.
- W4220932074 cites W2081465448 @default.
- W4220932074 cites W2082272203 @default.
- W4220932074 cites W2084375915 @default.
- W4220932074 cites W2085275390 @default.
- W4220932074 cites W2086137541 @default.
- W4220932074 cites W2087421341 @default.
- W4220932074 cites W2095249623 @default.
- W4220932074 cites W2095320189 @default.
- W4220932074 cites W2098791934 @default.
- W4220932074 cites W2102559055 @default.
- W4220932074 cites W2112055293 @default.
- W4220932074 cites W2114918609 @default.
- W4220932074 cites W2131487381 @default.
- W4220932074 cites W2131596261 @default.
- W4220932074 cites W2139126860 @default.
- W4220932074 cites W2146766225 @default.
- W4220932074 cites W2147593703 @default.
- W4220932074 cites W2148066122 @default.
- W4220932074 cites W2151948621 @default.
- W4220932074 cites W2159497139 @default.
- W4220932074 cites W2160518775 @default.
- W4220932074 cites W2166576553 @default.
- W4220932074 cites W2169302611 @default.
- W4220932074 cites W2224415831 @default.
- W4220932074 cites W2233252445 @default.
- W4220932074 cites W2289620705 @default.
- W4220932074 cites W2316088817 @default.
- W4220932074 cites W2320637374 @default.
- W4220932074 cites W2334323124 @default.
- W4220932074 cites W2418863935 @default.
- W4220932074 cites W2419346047 @default.
- W4220932074 cites W2469790428 @default.
- W4220932074 cites W2504691963 @default.
- W4220932074 cites W2520035938 @default.
- W4220932074 cites W2564891787 @default.
- W4220932074 cites W2566405543 @default.
- W4220932074 cites W2566958631 @default.
- W4220932074 cites W2580862813 @default.
- W4220932074 cites W2584378351 @default.
- W4220932074 cites W2593840863 @default.
- W4220932074 cites W2595752190 @default.
- W4220932074 cites W2604490519 @default.
- W4220932074 cites W2607510234 @default.
- W4220932074 cites W2617314594 @default.
- W4220932074 cites W2730712284 @default.
- W4220932074 cites W2741730500 @default.
- W4220932074 cites W2743327074 @default.
- W4220932074 cites W2754729758 @default.
- W4220932074 cites W2767683865 @default.
- W4220932074 cites W2772873089 @default.
- W4220932074 cites W2781525129 @default.
- W4220932074 cites W2781643461 @default.
- W4220932074 cites W2783225392 @default.
- W4220932074 cites W2783944564 @default.
- W4220932074 cites W2787969126 @default.
- W4220932074 cites W2800286012 @default.
- W4220932074 cites W2802969815 @default.
- W4220932074 cites W2808555448 @default.
- W4220932074 cites W2885741108 @default.
- W4220932074 cites W2891141728 @default.
- W4220932074 cites W2905633689 @default.
- W4220932074 cites W2906571646 @default.
- W4220932074 cites W2910317946 @default.
- W4220932074 cites W2916686451 @default.
- W4220932074 cites W2922236826 @default.
- W4220932074 cites W2934443399 @default.
- W4220932074 cites W2949215187 @default.
- W4220932074 cites W2949769764 @default.
- W4220932074 cites W2954572947 @default.