Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220932212> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4220932212 abstract "Placental and embryonic heart development occurs in parallel, and these organs have been proposed to exert reciprocal regulation during gestation. Poor placentation has been associated with congenital heart disease (CHD), an important cause of infant mortality. However, the mechanisms by which altered placental development can lead to CHD remain unresolved. In the current study we show that neutrophil-driven placental inflammation leads to inadequate placental development and loss of barrier function. Consequently, placental inflammatory monocytes of maternal origin become capable to migrate to the embryonic heart and alter the normal composition of resident cardiac macrophages and cardiac tissue structure. This cardiac impairment continues into postnatal life, hindering normal tissue architecture and function. Finally, we demonstrate that tempering placental inflammation can rescue this fetal cardiac defect and is sufficient to promote normal cardiac function in postnatal life. Taken together, our observations provide a mechanistic paradigm whereby neutrophil-driven inflammation in pregnancy can preclude normal embryonic heart development as a direct consequence of poor placental development." @default.
- W4220932212 created "2022-04-03" @default.
- W4220932212 creator A5004745599 @default.
- W4220932212 creator A5016097947 @default.
- W4220932212 creator A5032403221 @default.
- W4220932212 creator A5035962632 @default.
- W4220932212 creator A5043347649 @default.
- W4220932212 creator A5045094923 @default.
- W4220932212 creator A5051987410 @default.
- W4220932212 creator A5051999950 @default.
- W4220932212 creator A5064717028 @default.
- W4220932212 creator A5067833478 @default.
- W4220932212 creator A5073822857 @default.
- W4220932212 creator A5083530437 @default.
- W4220932212 date "2022-03-12" @default.
- W4220932212 modified "2023-10-16" @default.
- W4220932212 title "Placental inflammation leads to abnormal embryonic heart development" @default.
- W4220932212 doi "https://doi.org/10.1101/2022.03.10.482611" @default.
- W4220932212 hasPublicationYear "2022" @default.
- W4220932212 type Work @default.
- W4220932212 citedByCount "0" @default.
- W4220932212 crossrefType "posted-content" @default.
- W4220932212 hasAuthorship W4220932212A5004745599 @default.
- W4220932212 hasAuthorship W4220932212A5016097947 @default.
- W4220932212 hasAuthorship W4220932212A5032403221 @default.
- W4220932212 hasAuthorship W4220932212A5035962632 @default.
- W4220932212 hasAuthorship W4220932212A5043347649 @default.
- W4220932212 hasAuthorship W4220932212A5045094923 @default.
- W4220932212 hasAuthorship W4220932212A5051987410 @default.
- W4220932212 hasAuthorship W4220932212A5051999950 @default.
- W4220932212 hasAuthorship W4220932212A5064717028 @default.
- W4220932212 hasAuthorship W4220932212A5067833478 @default.
- W4220932212 hasAuthorship W4220932212A5073822857 @default.
- W4220932212 hasAuthorship W4220932212A5083530437 @default.
- W4220932212 hasBestOaLocation W42209322121 @default.
- W4220932212 hasConcept C104317684 @default.
- W4220932212 hasConcept C111566952 @default.
- W4220932212 hasConcept C126322002 @default.
- W4220932212 hasConcept C145103041 @default.
- W4220932212 hasConcept C172680121 @default.
- W4220932212 hasConcept C196843134 @default.
- W4220932212 hasConcept C203014093 @default.
- W4220932212 hasConcept C2776914184 @default.
- W4220932212 hasConcept C2776953305 @default.
- W4220932212 hasConcept C2777837822 @default.
- W4220932212 hasConcept C2778198053 @default.
- W4220932212 hasConcept C2779234561 @default.
- W4220932212 hasConcept C2780074459 @default.
- W4220932212 hasConcept C45167389 @default.
- W4220932212 hasConcept C54355233 @default.
- W4220932212 hasConcept C62425271 @default.
- W4220932212 hasConcept C71924100 @default.
- W4220932212 hasConcept C86803240 @default.
- W4220932212 hasConcept C87073359 @default.
- W4220932212 hasConcept C95444343 @default.
- W4220932212 hasConceptScore W4220932212C104317684 @default.
- W4220932212 hasConceptScore W4220932212C111566952 @default.
- W4220932212 hasConceptScore W4220932212C126322002 @default.
- W4220932212 hasConceptScore W4220932212C145103041 @default.
- W4220932212 hasConceptScore W4220932212C172680121 @default.
- W4220932212 hasConceptScore W4220932212C196843134 @default.
- W4220932212 hasConceptScore W4220932212C203014093 @default.
- W4220932212 hasConceptScore W4220932212C2776914184 @default.
- W4220932212 hasConceptScore W4220932212C2776953305 @default.
- W4220932212 hasConceptScore W4220932212C2777837822 @default.
- W4220932212 hasConceptScore W4220932212C2778198053 @default.
- W4220932212 hasConceptScore W4220932212C2779234561 @default.
- W4220932212 hasConceptScore W4220932212C2780074459 @default.
- W4220932212 hasConceptScore W4220932212C45167389 @default.
- W4220932212 hasConceptScore W4220932212C54355233 @default.
- W4220932212 hasConceptScore W4220932212C62425271 @default.
- W4220932212 hasConceptScore W4220932212C71924100 @default.
- W4220932212 hasConceptScore W4220932212C86803240 @default.
- W4220932212 hasConceptScore W4220932212C87073359 @default.
- W4220932212 hasConceptScore W4220932212C95444343 @default.
- W4220932212 hasLocation W42209322121 @default.
- W4220932212 hasLocation W42209322122 @default.
- W4220932212 hasLocation W42209322123 @default.
- W4220932212 hasOpenAccess W4220932212 @default.
- W4220932212 hasPrimaryLocation W42209322121 @default.
- W4220932212 hasRelatedWork W2105691292 @default.
- W4220932212 hasRelatedWork W2367870128 @default.
- W4220932212 hasRelatedWork W2374921697 @default.
- W4220932212 hasRelatedWork W2397095941 @default.
- W4220932212 hasRelatedWork W2809225164 @default.
- W4220932212 hasRelatedWork W2937867040 @default.
- W4220932212 hasRelatedWork W2981793018 @default.
- W4220932212 hasRelatedWork W4220932212 @default.
- W4220932212 hasRelatedWork W4228997471 @default.
- W4220932212 hasRelatedWork W4298385568 @default.
- W4220932212 isParatext "false" @default.
- W4220932212 isRetracted "false" @default.
- W4220932212 workType "article" @default.