Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220936779> ?p ?o ?g. }
- W4220936779 abstract "Metastatic uveal melanoma (UM) is a poor prognosis malignancy. Immunotherapy is commonly employed, despite the low activity, considering the lack of other effective systemic treatments. In this study, the prognostic and predictive role of soluble immune checkpoints and inflammatory cytokines/chemokines in 22 metastatic UM patients was evaluated. Baseline levels of these molecules were assessed, as well as their changes during anti-PD-1 therapy. The correlation between soluble immune checkpoints/cytokines/chemokines and survival was analyzed. A comparison between circulating immune profile of metastatic cutaneous melanoma (CM), for which immunotherapy is a mainstay of treatment, and UM during anti-PD-1 therapy was also performed. Three immune molecules resulted significantly higher in metastatic UM patients with survival <6 months versus patients with survival ≥6 months: IL-8, HVEM and IDO activity. Considering these three molecules, we obtained a baseline score able to predict patients’ survival. The same three molecules, together with soluble(s) CD137, sGITR and sCD27, resulted significantly lower in patients with survival >30 months. We also observed an increase of sCD137, sCD28, sPD-1, sPD-L2 sLAG3, sCD80 and sTim3 during anti-PD-1 treatment, as well as IDO activity, IP-10 and CCL2. Several of these molecules were significantly higher in UM compared to CM patients during anti-PD-1 therapy. The analysis of circulating immune molecules allows to identify patients with poor prognosis despite immunotherapy and patients with long survival treated with an anti-PD-1 agent. The different serum concentration of these molecules during anti-PD-1 therapy between UM and CM reflects the different efficacy of immune checkpoint inhibitors." @default.
- W4220936779 created "2022-04-03" @default.
- W4220936779 creator A5002449218 @default.
- W4220936779 creator A5006457492 @default.
- W4220936779 creator A5025723323 @default.
- W4220936779 creator A5030465858 @default.
- W4220936779 creator A5035469274 @default.
- W4220936779 creator A5035806516 @default.
- W4220936779 creator A5042989547 @default.
- W4220936779 creator A5049098422 @default.
- W4220936779 creator A5050215401 @default.
- W4220936779 creator A5059201916 @default.
- W4220936779 creator A5066692929 @default.
- W4220936779 creator A5067780934 @default.
- W4220936779 creator A5069311489 @default.
- W4220936779 creator A5078523828 @default.
- W4220936779 creator A5086585167 @default.
- W4220936779 date "2022-03-08" @default.
- W4220936779 modified "2023-09-30" @default.
- W4220936779 title "Circulating immune profile can predict survival of metastatic uveal melanoma patients: results of an exploratory study" @default.
- W4220936779 cites W1487223965 @default.
- W4220936779 cites W1526940895 @default.
- W4220936779 cites W1970051943 @default.
- W4220936779 cites W1979446198 @default.
- W4220936779 cites W1980664511 @default.
- W4220936779 cites W1991933930 @default.
- W4220936779 cites W2005576578 @default.
- W4220936779 cites W2009519656 @default.
- W4220936779 cites W2019054427 @default.
- W4220936779 cites W2022430924 @default.
- W4220936779 cites W2052787011 @default.
- W4220936779 cites W2055835855 @default.
- W4220936779 cites W2056737202 @default.
- W4220936779 cites W2098835477 @default.
- W4220936779 cites W2110228704 @default.
- W4220936779 cites W2148567638 @default.
- W4220936779 cites W2152857351 @default.
- W4220936779 cites W2157800695 @default.
- W4220936779 cites W2166771927 @default.
- W4220936779 cites W2334064776 @default.
- W4220936779 cites W2342956596 @default.
- W4220936779 cites W2515516401 @default.
- W4220936779 cites W2535141202 @default.
- W4220936779 cites W2617691667 @default.
- W4220936779 cites W2766411327 @default.
- W4220936779 cites W2793005533 @default.
- W4220936779 cites W2799492638 @default.
- W4220936779 cites W2887169335 @default.
- W4220936779 cites W2900360032 @default.
- W4220936779 cites W2902775411 @default.
- W4220936779 cites W2936616584 @default.
- W4220936779 cites W2947160888 @default.
- W4220936779 cites W2949122086 @default.
- W4220936779 cites W2963663221 @default.
- W4220936779 cites W3001381700 @default.
- W4220936779 cites W3002686604 @default.
- W4220936779 cites W3004644975 @default.
- W4220936779 cites W3005797249 @default.
- W4220936779 cites W3021646013 @default.
- W4220936779 cites W3022826062 @default.
- W4220936779 cites W3040791408 @default.
- W4220936779 cites W3043478852 @default.
- W4220936779 cites W3085853688 @default.
- W4220936779 cites W3097624000 @default.
- W4220936779 cites W3120989185 @default.
- W4220936779 cites W3155097581 @default.
- W4220936779 cites W3165102087 @default.
- W4220936779 cites W65135050 @default.
- W4220936779 doi "https://doi.org/10.1080/21645515.2022.2034377" @default.
- W4220936779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35258435" @default.
- W4220936779 hasPublicationYear "2022" @default.
- W4220936779 type Work @default.
- W4220936779 citedByCount "4" @default.
- W4220936779 countsByYear W42209367792022 @default.
- W4220936779 countsByYear W42209367792023 @default.
- W4220936779 crossrefType "journal-article" @default.
- W4220936779 hasAuthorship W4220936779A5002449218 @default.
- W4220936779 hasAuthorship W4220936779A5006457492 @default.
- W4220936779 hasAuthorship W4220936779A5025723323 @default.
- W4220936779 hasAuthorship W4220936779A5030465858 @default.
- W4220936779 hasAuthorship W4220936779A5035469274 @default.
- W4220936779 hasAuthorship W4220936779A5035806516 @default.
- W4220936779 hasAuthorship W4220936779A5042989547 @default.
- W4220936779 hasAuthorship W4220936779A5049098422 @default.
- W4220936779 hasAuthorship W4220936779A5050215401 @default.
- W4220936779 hasAuthorship W4220936779A5059201916 @default.
- W4220936779 hasAuthorship W4220936779A5066692929 @default.
- W4220936779 hasAuthorship W4220936779A5067780934 @default.
- W4220936779 hasAuthorship W4220936779A5069311489 @default.
- W4220936779 hasAuthorship W4220936779A5078523828 @default.
- W4220936779 hasAuthorship W4220936779A5086585167 @default.
- W4220936779 hasBestOaLocation W42209367791 @default.
- W4220936779 hasConcept C10515644 @default.
- W4220936779 hasConcept C126322002 @default.
- W4220936779 hasConcept C13373296 @default.
- W4220936779 hasConcept C143998085 @default.
- W4220936779 hasConcept C203014093 @default.
- W4220936779 hasConcept C2777658100 @default.
- W4220936779 hasConcept C2777701055 @default.
- W4220936779 hasConcept C2779399171 @default.