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- W4220946416 endingPage "1308" @default.
- W4220946416 startingPage "1294" @default.
- W4220946416 abstract "Diabetic wounds are one of the debilitating complications that affect up to 20% of diabetic patients. Despite the advent of extensive therapies, the recovery rate is unsatisfactory, and approximately, 25% of patients undergo amputation, thereby demanding alternative therapeutic strategies. On the basis of the individual therapeutic roles of the miR-155 inhibitor and mesenchymal stem cells (MSC)-derived exosomes, we conjectured that the combination of the miR-155 inhibitor and MSC-derived exosomes would have synergy in diabetic wound healing. Herein, miR-155-inhibitor-loaded MSC-derived exosomes showed synergistic effects in keratinocyte migration, restoration of FGF-7 levels, and anti-inflammatory action, leading to accelerated wound healing mediated by negative regulation of miR-155, using an in vitro co-culture model and in vivo mouse model of the diabetic wound. Furthermore, treatment with miR-155-inhibitor-loaded MSC-derived exosomes led to enhanced collagen deposition, angiogenesis, and re-epithelialization in diabetic wounds. This study revealed the therapeutic potential of miR-155-inhibitor-loaded MSC-derived exosomes in diabetic wound healing and opened the doors for encapsulating miRNAs along with antibiotics within the MSC-derived exosomes toward improved management of chronic, nonhealing diabetic wounds." @default.
- W4220946416 created "2022-04-03" @default.
- W4220946416 creator A5035117337 @default.
- W4220946416 creator A5041054709 @default.
- W4220946416 creator A5043852414 @default.
- W4220946416 creator A5080300400 @default.
- W4220946416 creator A5082544781 @default.
- W4220946416 creator A5083501112 @default.
- W4220946416 creator A5088574776 @default.
- W4220946416 date "2022-05-02" @default.
- W4220946416 modified "2023-10-16" @default.
- W4220946416 title "Mesenchymal Stem Cell-Derived Exosomes Loaded with miR-155 Inhibitor Ameliorate Diabetic Wound Healing." @default.
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