FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220947468> ?p ?o ?g. }

• W4220947468 endingPage "S375" @default.
• W4220947468 startingPage "S374" @default.
• W4220947468 abstract "Both decreased and increased cell-free (cf) DNA fetal fractions are associated with adverse obstetric outcomes in singleton pregnancies. The aim of this study was to evaluate the association between cfDNA fetal fraction and adverse obstetric outcomes in twin pregnancies in a large geographically diverse population. This is a planned secondary analysis of data from a retrospective cohort study aimed to evaluate cfDNA screening in twins seen at 17 centers between 12/2011 and 2/2020. CfDNA screening was performed by one clinical laboratory using a massively parallel sequencing approach. Cases with a vanishing twin, confirmed trisomy 21, 13 or 18 in one or both twins, and incomplete pregnancy outcome data were excluded. The initial fetal fraction result was used for cases with an initial non-reportable result. Univariate analyses were performed using Pearson Chi-square, Fisher's exact and Kruskall-Wallis tests. Multivariate logistic regression models were used to account for confounding. A total of 1,771 samples were sent for cfDNA screening. 72 cases with a vanishing twin, 57 cases with one or both twins diagnosed with trisomy 21, 18 or 13, and 247 cases with inadequate follow up were excluded leaving a total of 1,395 cases for inclusion in the analysis. The median maternal age was 35 years, the median gestational age was 12 weeks, the majority of twins were dichorionic and 590 (42%) were conceived with in-vitro fertilization. Black race, higher body mass index (BMI), chronic hypertension (CHTN), pre-existing diabetes (DM), and treatment with low molecular weight heparin were all associated with fetal fraction <5th percentile. Older gestational age (GA) at cfDNA blood draw was associated with fetal fraction >95th percentile. Fetal fraction <5th percentile was associated with gestational diabetes. This remained significant after adjustment for race, BMI, GA at blood draw and CHTN (aOR 2.11; 95% CI 1.12-3.99). In the univariate analysis fetal fraction >95th percentile was associated with having one or both twins with a birth weight <5th percentile and <10th percentile. However, after adjustment for race, BMI, GA at blood draw, and CHTN, fetal fraction >95th percentile was only associated with increased odds of having one or both twins with a birth weight <5th percentile (aOR 2.05; 95% CI 1.20-3.49). Women with a twin gestation with a low fetal fraction are at increased risk of developing GDM while women with an elevated fetal fraction are at increased risk of having one or both twins with a birth weight <5th percentile. This information may prove helpful in determining the optimal screening approaches for these conditions in women with twin gestations.Table 1Patient Characteristics and Pregnancy OutcomesLow FF (<5%ile) (n=69)Normal FF (≥5 to ≤95%ile)(n=1,255)High FF (>95%ile) (n=71)p-valueAge (yrs) median [IQR]36 [33-39]35 [33-38]35 [33-38]0.593Parity, n (%)0.096P032 (46)683 (54)33 (47)P119 (28)359 (29)18 (26)P210 (14)121 (10)14 (20)P3+8 (12)92 (7)5 (7)Race, n (%)0.039White40 (59)858 (69)52 (74)Black17 (25)128 (10)8 (11)Asian7 (10)149 (12)5 (7)Other4 (6)106 (9)5 (7)GA at cfDNA draw (wks) median [IQR]12.4 [12.0-13.4]12.3 [11.3-13.4]13.0 [12.0-19.0]<0.001Trimester<0.0011st60 (87)1006 (80)40 (56)2nd9 (13)232 (18)23 (32)3rd0 (0)17 (1)8 (11)BMI (mg/kg2) median [IQR]31.4 [26.6-38.5]24.9 [22.2-29.2]23.2 [21.8-27.2]<0.001Chronic Hypertension, n (%)12 (17)65 (5)3 (3)0.001Pregestational Diabetes, n (%)4 (5)19 (2)0 (0)0.032Treatment with low molecular weight heparin, n (%)5 (7)38 (3)0 (0)0.049IVF conception, n (%)24 (35)538 (43)28 (39)0.367Chorionicity0.8Dichorionic, n (%)56 (81)1000 (80)59 (83)Monochorionic, n (%)13 (19)250 (20)12 (17)Pregnancy OutcomesGA at delivery, mean weeks36.3 [34.4-37.4]36.4 [34.4-37.4]36.6 [34.3-37.4]0.935Mean Bwt of both twins, g2468.8 [2081.3-2817.5]2467 [2052.5-2780]2370 [2100-2632.5]0.665Preeclampsia14 (21)217 (17)10 (14)0.622PTB <37 weeks42 (61)737 (59)42 (60)0.93PTB <34 weeks15 (22)262 (21)14 (20)0.969PTB <32 weeks10 (14)151 (12)7 (10)0.717PTB <28 weeks6 (9)64 (5)3 (4)0.415Gestational diabetes15 (22)128 (10)9 (13)0.009Bwt < 10th percentile for GA - 1 or both twins19 (29)462 (38)36 (53)0.012Bwt < 5th percentile for GA 1 or both twins12 (18)283 (23)28 (41)0.002KeyGAGestational AgeBwtBirth WeightPTBPreterm Birth Open table in a new tab" @default.
• W4220947468 created "2022-04-03" @default.
• W4220947468 creator A5023648644 @default.
• W4220947468 creator A5040500360 @default.
• W4220947468 creator A5043995631 @default.
• W4220947468 creator A5070794728 @default.
• W4220947468 creator A5087109213 @default.
• W4220947468 date "2022-03-01" @default.
• W4220947468 modified "2023-09-26" @default.
• W4220947468 title "OP050: Cell-free DNA fetal fraction and adverse obstetric outcomes in twin pregnancy" @default.
• W4220947468 doi "https://doi.org/10.1016/j.gim.2022.01.596" @default.
• W4220947468 hasPublicationYear "2022" @default.
• W4220947468 type Work @default.
• W4220947468 citedByCount "0" @default.
• W4220947468 crossrefType "journal-article" @default.
• W4220947468 hasAuthorship W4220947468A5023648644 @default.
• W4220947468 hasAuthorship W4220947468A5040500360 @default.
• W4220947468 hasAuthorship W4220947468A5043995631 @default.
• W4220947468 hasAuthorship W4220947468A5070794728 @default.
• W4220947468 hasAuthorship W4220947468A5087109213 @default.
• W4220947468 hasBestOaLocation W42209474681 @default.
• W4220947468 hasConcept C117354338 @default.
• W4220947468 hasConcept C126322002 @default.
• W4220947468 hasConcept C131872663 @default.
• W4220947468 hasConcept C149629883 @default.
• W4220947468 hasConcept C152110520 @default.
• W4220947468 hasConcept C172680121 @default.
• W4220947468 hasConcept C178790620 @default.
• W4220947468 hasConcept C185592680 @default.
• W4220947468 hasConcept C197934379 @default.
• W4220947468 hasConcept C2778258057 @default.
• W4220947468 hasConcept C2779234561 @default.
• W4220947468 hasConcept C2908647359 @default.
• W4220947468 hasConcept C2909855057 @default.
• W4220947468 hasConcept C54355233 @default.
• W4220947468 hasConcept C71924100 @default.
• W4220947468 hasConcept C86803240 @default.
• W4220947468 hasConcept C99454951 @default.
• W4220947468 hasConceptScore W4220947468C117354338 @default.
• W4220947468 hasConceptScore W4220947468C126322002 @default.
• W4220947468 hasConceptScore W4220947468C131872663 @default.
• W4220947468 hasConceptScore W4220947468C149629883 @default.
• W4220947468 hasConceptScore W4220947468C152110520 @default.
• W4220947468 hasConceptScore W4220947468C172680121 @default.
• W4220947468 hasConceptScore W4220947468C178790620 @default.
• W4220947468 hasConceptScore W4220947468C185592680 @default.
• W4220947468 hasConceptScore W4220947468C197934379 @default.
• W4220947468 hasConceptScore W4220947468C2778258057 @default.
• W4220947468 hasConceptScore W4220947468C2779234561 @default.
• W4220947468 hasConceptScore W4220947468C2908647359 @default.
• W4220947468 hasConceptScore W4220947468C2909855057 @default.
• W4220947468 hasConceptScore W4220947468C54355233 @default.
• W4220947468 hasConceptScore W4220947468C71924100 @default.
• W4220947468 hasConceptScore W4220947468C86803240 @default.
• W4220947468 hasConceptScore W4220947468C99454951 @default.
• W4220947468 hasIssue "3" @default.
• W4220947468 hasLocation W42209474681 @default.
• W4220947468 hasOpenAccess W4220947468 @default.
• W4220947468 hasPrimaryLocation W42209474681 @default.
• W4220947468 hasRelatedWork W111324035 @default.
• W4220947468 hasRelatedWork W1987174675 @default.
• W4220947468 hasRelatedWork W2169514348 @default.
• W4220947468 hasRelatedWork W2338643548 @default.
• W4220947468 hasRelatedWork W2377852199 @default.
• W4220947468 hasRelatedWork W2380824334 @default.
• W4220947468 hasRelatedWork W2416190606 @default.
• W4220947468 hasRelatedWork W2440261202 @default.
• W4220947468 hasRelatedWork W2443136477 @default.
• W4220947468 hasRelatedWork W3129352084 @default.
• W4220947468 hasVolume "24" @default.
• W4220947468 isParatext "false" @default.
• W4220947468 isRetracted "false" @default.
• W4220947468 workType "article" @default.