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- W4220948887 abstract "Fungal pollution of indoor environments contributes to several allergic symptoms and represents a public health problem. It is well-established that 1-octen-3-ol, also known as mushroom alcohol, is a fungal volatile organic compound (VOC) commonly found in damp indoor spaces and responsible for the typical musty odor. Previously it was reported that exposure to 1-octen-3-ol induced inflammations and disrupted mitochondrial morphology and bioenergetic rate in Drosophila melanogaster. The aim of this study was to examine the influence of 1-octen-3-ol on dehydrogenase activity, apoptotic biomarkers, levels of nitric oxide (NO) and reactive oxygen species (ROS), as well as antioxidant enzymes activities. D. melanogaster flies were exposed to an atmosphere containing 1-octen-3-ol (2.5 or ∞l/L) for 24 hr. Data demonstrated that 1-octen-3-ol decreased dehydrogenases activity and NO levels but increased ROS levels accompanied by stimulation of glutathione-S-transferase (GST) and superoxide dismutase (SOD) activities without altering caspase 3/7 activation. These findings indicate that adverse mitochondrial activity effects following exposure of D. melanogaster to 1-octen-3-ol, a fungal VOC, may be attributed to oxidant stress. The underlying mechanisms involved in adverse consequences of indoor fungal exposure appear to be related to necrotic but not apoptotic mechanisms. The adverse consequences were sex-dependent with males displaying higher sensitivity to 1-octen-3-ol. Based upon on the fact that the fly genome shares nearly 75% of disease-related genes to human exposure to this fungus may explain the adverse human responses to mold especially for males." @default.
- W4220948887 created "2022-04-03" @default.
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- W4220948887 date "2022-03-31" @default.
- W4220948887 modified "2023-10-14" @default.
- W4220948887 title "Effect of fungal indoor air pollutant 1-octen-3-ol on levels of reactive oxygen species and nitric oxide as well as dehydrogenases activities in<i>drosophila melanogaster</i>males" @default.
- W4220948887 cites W1850010945 @default.
- W4220948887 cites W1963549510 @default.
- W4220948887 cites W1977265439 @default.
- W4220948887 cites W1988681233 @default.
- W4220948887 cites W1995610231 @default.
- W4220948887 cites W2002186465 @default.
- W4220948887 cites W2006943116 @default.
- W4220948887 cites W2016471390 @default.
- W4220948887 cites W2048417788 @default.
- W4220948887 cites W2048775885 @default.
- W4220948887 cites W2050801315 @default.
- W4220948887 cites W2057984671 @default.
- W4220948887 cites W2058898888 @default.
- W4220948887 cites W2066370231 @default.
- W4220948887 cites W2092596800 @default.
- W4220948887 cites W2128404190 @default.
- W4220948887 cites W2128877928 @default.
- W4220948887 cites W2131802378 @default.
- W4220948887 cites W2134444800 @default.
- W4220948887 cites W2138598670 @default.
- W4220948887 cites W2139477052 @default.
- W4220948887 cites W2140674158 @default.
- W4220948887 cites W2154385453 @default.
- W4220948887 cites W2261053929 @default.
- W4220948887 cites W2315022632 @default.
- W4220948887 cites W2325677894 @default.
- W4220948887 cites W2345084601 @default.
- W4220948887 cites W2414940744 @default.
- W4220948887 cites W2519067843 @default.
- W4220948887 cites W2535611178 @default.
- W4220948887 cites W2558957694 @default.
- W4220948887 cites W2615385606 @default.
- W4220948887 cites W2625838763 @default.
- W4220948887 cites W2739940592 @default.
- W4220948887 cites W2744719759 @default.
- W4220948887 cites W2752741284 @default.
- W4220948887 cites W2766318212 @default.
- W4220948887 cites W2767953804 @default.
- W4220948887 cites W2789634591 @default.
- W4220948887 cites W2791171542 @default.
- W4220948887 cites W2791767507 @default.
- W4220948887 cites W2792201621 @default.
- W4220948887 cites W2793148366 @default.
- W4220948887 cites W2807719187 @default.
- W4220948887 cites W2864450853 @default.
- W4220948887 cites W2886135949 @default.
- W4220948887 cites W2906243068 @default.
- W4220948887 cites W2939114139 @default.
- W4220948887 cites W2963550812 @default.
- W4220948887 cites W2974890858 @default.
- W4220948887 cites W2991332964 @default.
- W4220948887 cites W3004531975 @default.
- W4220948887 cites W3013339399 @default.
- W4220948887 cites W3016755002 @default.
- W4220948887 cites W3017380227 @default.
- W4220948887 cites W3020484714 @default.
- W4220948887 cites W3032034527 @default.
- W4220948887 cites W3037847225 @default.
- W4220948887 cites W3048867839 @default.
- W4220948887 cites W3083621089 @default.
- W4220948887 cites W3084173819 @default.
- W4220948887 cites W3085180538 @default.
- W4220948887 cites W3087988814 @default.
- W4220948887 cites W3107449170 @default.
- W4220948887 cites W3109809477 @default.
- W4220948887 cites W3125778854 @default.
- W4220948887 cites W3149477552 @default.
- W4220948887 cites W3154938288 @default.
- W4220948887 cites W3176113835 @default.
- W4220948887 cites W3194125335 @default.
- W4220948887 cites W4230959076 @default.
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- W4220948887 cites W753458319 @default.
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- W4220948887 doi "https://doi.org/10.1080/15287394.2022.2054887" @default.
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