FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220952016> ?p ?o ?g. }

• W4220952016 abstract "Abstract Background COVID-19, caused by the SARS-CoV-2 virus, is a severe inflammatory condition. Patients with pre-existing conditions including diabetes, hypertension, and cardiovascular disease are at particularly high risk of complications. Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare and debilitating genetic disorder that is characterized by a pro-inflammatory state, which leads to progressive heterotopic ossification and complications after trauma, including intramuscular vaccinations. To better understand the impact of COVID-19 on patients with FOP, we first examined the social impact of the pandemic using data from the FOP Registry managed by the International FOP Association. We also identified patients with FOP who were exposed to or contracted the SARS-CoV-2 virus, or who received a COVID-19 vaccine, to investigate if patients with FOP were at increased risks of complications from SARS-CoV2 exposure or vaccination. Results Data from 326 individuals in 69 countries in the International FOP Association FOP Connection Registry were examined using patient-reported outcomes measurement information system (PROMIS) global health scale scores. Twenty-six (28.9%) participants aged ≥ 15 years old rated their satisfaction with their social activities and relationships as poor in 2020, which was an increase from 18 (18.9%) in 2019, prior to the SARS-CoV-2 outbreak. Similar trends were noted for physical and mental health in the pediatric population. Frequency of physician visits was not changed, but a larger portion of patients reported missing dental visits in 2020 compared with 2019 (31.5% vs. 41.7%). A second cohort with 32 subjects was tracked after SARS-CoV-2 exposure or vaccination. Ten subjects were positively diagnosed with COVID-19, 15 received a COVID-19 vaccine, and seven had high-risk SARS-CoV-2 exposure but either did not have a confirmed clinical diagnosis or tested negative. Subjects who tested positive for the virus showed no major complications or increased FOP disease activity, though our sample size is very limited. Among the 15 subjects who received a COVID-19 vaccine, using the International Clinical Council on FOP guidelines for prophylaxis with ibuprofen or acetaminophen, only one person experienced flare-like activity at the injection site. Conclusions Patients with FOP showed a significant decrease in social activities that was reflective of the isolation and mobility changes in this debilitated population. In our limited cohort, the majority of the patients with FOP who tested positive for COVID-19 showed no major complications. Also, although limited in sample size, the majority of patients who received a COVID-19 vaccination and followed guidelines from the FOP International Clinical Council tolerated vaccination well. Only one person experiencing flare activity following their injection. Thus, the risks and benefits of COVID-19 vaccination needs to be discussed carefully so as to support informed decisions." @default.
• W4220952016 created "2022-04-03" @default.
• W4220952016 creator A5006543326 @default.
• W4220952016 creator A5007520257 @default.
• W4220952016 creator A5016214713 @default.
• W4220952016 creator A5059483632 @default.
• W4220952016 creator A5060020362 @default.
• W4220952016 creator A5069676493 @default.
• W4220952016 creator A5074598833 @default.
• W4220952016 creator A5075866257 @default.
• W4220952016 creator A5085389703 @default.
• W4220952016 creator A5090054715 @default.
• W4220952016 date "2022-03-04" @default.
• W4220952016 modified "2023-10-10" @default.
• W4220952016 title "Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva" @default.
• W4220952016 cites W1908563203 @default.
• W4220952016 cites W1982871919 @default.
• W4220952016 cites W2031399599 @default.
• W4220952016 cites W2032262606 @default.
• W4220952016 cites W2041377514 @default.
• W4220952016 cites W2066050937 @default.
• W4220952016 cites W2080929272 @default.
• W4220952016 cites W2107748660 @default.
• W4220952016 cites W2145304853 @default.
• W4220952016 cites W2154767933 @default.
• W4220952016 cites W2750945948 @default.
• W4220952016 cites W2754400581 @default.
• W4220952016 cites W2755781951 @default.
• W4220952016 cites W2762933082 @default.
• W4220952016 cites W2901605365 @default.
• W4220952016 cites W2913698357 @default.
• W4220952016 cites W2998311215 @default.
• W4220952016 cites W3005673308 @default.
• W4220952016 cites W3015076624 @default.
• W4220952016 cites W3023071153 @default.
• W4220952016 cites W3029529029 @default.
• W4220952016 cites W3046496943 @default.
• W4220952016 cites W3096854549 @default.
• W4220952016 cites W3111878194 @default.
• W4220952016 cites W311927316 @default.
• W4220952016 cites W3128562093 @default.
• W4220952016 cites W3133275077 @default.
• W4220952016 cites W3137394362 @default.
• W4220952016 cites W3138643675 @default.
• W4220952016 cites W3165656738 @default.
• W4220952016 cites W3169359001 @default.
• W4220952016 cites W3172009415 @default.
• W4220952016 cites W3186040648 @default.
• W4220952016 cites W4205842629 @default.
• W4220952016 doi "https://doi.org/10.1186/s13023-022-02246-4" @default.
• W4220952016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35246171" @default.
• W4220952016 hasPublicationYear "2022" @default.
• W4220952016 type Work @default.
• W4220952016 citedByCount "3" @default.
• W4220952016 countsByYear W42209520162022 @default.
• W4220952016 countsByYear W42209520162023 @default.
• W4220952016 crossrefType "journal-article" @default.
• W4220952016 hasAuthorship W4220952016A5006543326 @default.
• W4220952016 hasAuthorship W4220952016A5007520257 @default.
• W4220952016 hasAuthorship W4220952016A5016214713 @default.
• W4220952016 hasAuthorship W4220952016A5059483632 @default.
• W4220952016 hasAuthorship W4220952016A5060020362 @default.
• W4220952016 hasAuthorship W4220952016A5069676493 @default.
• W4220952016 hasAuthorship W4220952016A5074598833 @default.
• W4220952016 hasAuthorship W4220952016A5075866257 @default.
• W4220952016 hasAuthorship W4220952016A5085389703 @default.
• W4220952016 hasAuthorship W4220952016A5090054715 @default.
• W4220952016 hasBestOaLocation W42209520161 @default.
• W4220952016 hasConcept C126322002 @default.
• W4220952016 hasConcept C141071460 @default.
• W4220952016 hasConcept C2777995074 @default.
• W4220952016 hasConcept C2779134260 @default.
• W4220952016 hasConcept C2780650075 @default.
• W4220952016 hasConcept C2908647359 @default.
• W4220952016 hasConcept C3008058167 @default.
• W4220952016 hasConcept C524204448 @default.
• W4220952016 hasConcept C71924100 @default.
• W4220952016 hasConcept C72563966 @default.
• W4220952016 hasConcept C89623803 @default.
• W4220952016 hasConcept C99454951 @default.
• W4220952016 hasConceptScore W4220952016C126322002 @default.
• W4220952016 hasConceptScore W4220952016C141071460 @default.
• W4220952016 hasConceptScore W4220952016C2777995074 @default.
• W4220952016 hasConceptScore W4220952016C2779134260 @default.
• W4220952016 hasConceptScore W4220952016C2780650075 @default.
• W4220952016 hasConceptScore W4220952016C2908647359 @default.
• W4220952016 hasConceptScore W4220952016C3008058167 @default.
• W4220952016 hasConceptScore W4220952016C524204448 @default.
• W4220952016 hasConceptScore W4220952016C71924100 @default.
• W4220952016 hasConceptScore W4220952016C72563966 @default.
• W4220952016 hasConceptScore W4220952016C89623803 @default.
• W4220952016 hasConceptScore W4220952016C99454951 @default.
• W4220952016 hasFunder F4320337362 @default.
• W4220952016 hasFunder F4320337582 @default.
• W4220952016 hasIssue "1" @default.
• W4220952016 hasLocation W42209520161 @default.
• W4220952016 hasLocation W42209520162 @default.
• W4220952016 hasLocation W42209520163 @default.
• W4220952016 hasLocation W42209520164 @default.
• W4220952016 hasLocation W42209520165 @default.

• next