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- W4220953969 abstract "Circular RNAs (circRNAs) are a novel class of endogenous non‑coding RNAs that have been recently regarded as functionally active. CircRNAs are remarkably stable and known to possess several biological functions such as microRNA sponging, regulating transcription and splicing and occasionally acting as polypeptide‑producing templates. CircRNAs show tissue‑specific expression and have been reported to be associated with the progression of several types of malignancies. Given the recent progress in genome sequencing and bioinformatics techniques, a rapid increment in the biological role of circRNAs has been observed. Concurrently, the patent search from different patent databases shows that the patent number of circRNA is increasing very quickly. These phenomena reveal a rapid development of the technological landscape. In the present review, the recent progress on circRNAs in various kinds of cancer has been investigated and their function as biomarkers or therapeutic targets and their technological landscape have been appreciated. A new insight into circRNAs structure and functional capabilities in cancer has been reviewed. Continually increasing knowledge on their critical role during cancer progression is projecting them as biomarkers or therapeutic targets for various kinds of cancer. Thus, recent updates on the functional role of circRNAs in terms of the technological landscape, clinical opportunities (biomarkers and therapeutic targets), and challenges in cancer have been illustrated." @default.
- W4220953969 created "2022-04-03" @default.
- W4220953969 creator A5001497588 @default.
- W4220953969 creator A5020432140 @default.
- W4220953969 creator A5033972031 @default.
- W4220953969 creator A5055323268 @default.
- W4220953969 creator A5056540491 @default.
- W4220953969 creator A5089666279 @default.
- W4220953969 date "2022-03-31" @default.
- W4220953969 modified "2023-10-06" @default.
- W4220953969 title "Recent progress of circular RNAs in different types of human cancer: Technological landscape, clinical opportunities and challenges (Review)" @default.
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