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• W4220954634 endingPage "114219" @default.
• W4220954634 startingPage "114219" @default.
• W4220954634 abstract "Despite significant eradication efforts, malaria remains a persistent infectious disease with high mortality due to the lack of efficient point-of-care (PoC) screening solutions required to manage low-density asymptomatic parasitemia. In response, we demonstrate a quantitative electrical biosensor based on system-integrated two-dimensional field-effect transistors (2DBioFETs) of reduced graphene oxide (rGO) as transducer for high sensitivity screening of the main malaria biomarker, Plasmodium falciparum lactate dehydrogenase (PfLDH). The 2DBioFETs were biofunctionalized with pyrene-modified 2008s aptamers as specific PfLDH receptors. While we systematically optimize biosensor interface for optimal performance, aptamer-protein transduction at 2DBioFETs is elucidated based on delineation of charge and capacitance in an updated analytical model for two-dimensional rGO/biofunctional layer/electrolyte (2DiBLE) interfaces. Our 2DBioFET-aptasensors display a limit-of-detection down to 0.78 fM (0.11 pg/mL), dynamic ranges over 9 orders of magnitude (subfemto to submicromolar), high sensitivity, and selectivity in human serum validating their diagnostic potential as rapid PoC tests for malarial management." @default.
• W4220954634 created "2022-04-03" @default.
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• W4220954634 date "2022-07-01" @default.
• W4220954634 modified "2023-10-18" @default.
• W4220954634 title "Delineating charge and capacitance transduction in system-integrated graphene-based BioFETs used as aptasensors for malaria detection" @default.
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• W4220954634 doi "https://doi.org/10.1016/j.bios.2022.114219" @default.
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