Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220956108> ?p ?o ?g. }
- W4220956108 endingPage "408" @default.
- W4220956108 startingPage "403" @default.
- W4220956108 abstract "Sjogren's syndrome and radiation therapy for head and neck cancers are often accompanied by xerostomia. Oral pilocarpine (PCP) to treat xerostomia produces systemic side effects, such as runny nose and lacrimation. To improve the therapeutic efficacy of PCP and reduce the aforementioned side effects, we developed a topical delivery system for PCP using freeze-dried sheets of hyaluronic acid (HA). The advantages of HA sheets over conventional oral formulations were examined through in vivo pharmacokinetic and pharmacodynamic studies after their application to oral tissues and salivary glands. The concentration of PCP in the submucosal tissue of the oral cavity was determined using the microdialysis (MD) method after buccal application of HA sheets containing PCP to hamsters. The concentration of PCP in the MD outflow was quite low after gastric administration, whereas the PCP concentration in plasma was high. In contrast, after buccal application of HA sheets containing PCP, the concentration of the drug in the MD outflow increased, despite the negligible concentration in plasma. These findings indicated that both enhancement of saliva secretion and the avoidance of systemic side effects could be achieved through buccal administration of PCP-loaded HA sheets. In addition, the pharmacodynamic study showed that when compared with intravenous and gastric administration, salivary application of HA sheets containing PCP resulted in similar volumes of saliva secretion and reduced lacrimal secretions. In conclusion, freeze-dried HA sheets allow for the development of a novel buccal delivery system with enhanced therapeutic efficacy and safety to treat xerostomia." @default.
- W4220956108 created "2022-04-03" @default.
- W4220956108 creator A5004453040 @default.
- W4220956108 creator A5009560589 @default.
- W4220956108 creator A5019260289 @default.
- W4220956108 creator A5025085721 @default.
- W4220956108 creator A5031345028 @default.
- W4220956108 creator A5042472487 @default.
- W4220956108 creator A5065017388 @default.
- W4220956108 creator A5072821254 @default.
- W4220956108 creator A5076675171 @default.
- W4220956108 date "2022-04-01" @default.
- W4220956108 modified "2023-09-26" @default.
- W4220956108 title "Topical Xerostomia Treatment with Hyaluronate Sheets Containing Pilocarpine" @default.
- W4220956108 cites W1846716296 @default.
- W4220956108 cites W1948079628 @default.
- W4220956108 cites W1968252223 @default.
- W4220956108 cites W1985992810 @default.
- W4220956108 cites W2014472765 @default.
- W4220956108 cites W2020406291 @default.
- W4220956108 cites W2021861978 @default.
- W4220956108 cites W2025463706 @default.
- W4220956108 cites W2035964286 @default.
- W4220956108 cites W2051241986 @default.
- W4220956108 cites W2051379292 @default.
- W4220956108 cites W2057022548 @default.
- W4220956108 cites W2059999995 @default.
- W4220956108 cites W2069945296 @default.
- W4220956108 cites W2094334681 @default.
- W4220956108 cites W2102267945 @default.
- W4220956108 cites W2123924347 @default.
- W4220956108 cites W2158761205 @default.
- W4220956108 cites W2169523266 @default.
- W4220956108 cites W2285248226 @default.
- W4220956108 cites W2299037874 @default.
- W4220956108 cites W2742100951 @default.
- W4220956108 cites W2744570286 @default.
- W4220956108 cites W2745611150 @default.
- W4220956108 cites W2809995586 @default.
- W4220956108 cites W2898763666 @default.
- W4220956108 cites W2946864560 @default.
- W4220956108 cites W2973028089 @default.
- W4220956108 cites W2991260146 @default.
- W4220956108 cites W3101311865 @default.
- W4220956108 cites W3133631227 @default.
- W4220956108 cites W4240395620 @default.
- W4220956108 doi "https://doi.org/10.1248/bpb.b21-00763" @default.
- W4220956108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35370264" @default.
- W4220956108 hasPublicationYear "2022" @default.
- W4220956108 type Work @default.
- W4220956108 citedByCount "4" @default.
- W4220956108 countsByYear W42209561082022 @default.
- W4220956108 countsByYear W42209561082023 @default.
- W4220956108 crossrefType "journal-article" @default.
- W4220956108 hasAuthorship W4220956108A5004453040 @default.
- W4220956108 hasAuthorship W4220956108A5009560589 @default.
- W4220956108 hasAuthorship W4220956108A5019260289 @default.
- W4220956108 hasAuthorship W4220956108A5025085721 @default.
- W4220956108 hasAuthorship W4220956108A5031345028 @default.
- W4220956108 hasAuthorship W4220956108A5042472487 @default.
- W4220956108 hasAuthorship W4220956108A5065017388 @default.
- W4220956108 hasAuthorship W4220956108A5072821254 @default.
- W4220956108 hasAuthorship W4220956108A5076675171 @default.
- W4220956108 hasBestOaLocation W42209561081 @default.
- W4220956108 hasConcept C111113717 @default.
- W4220956108 hasConcept C112705442 @default.
- W4220956108 hasConcept C118552586 @default.
- W4220956108 hasConcept C126322002 @default.
- W4220956108 hasConcept C195735259 @default.
- W4220956108 hasConcept C2777056448 @default.
- W4220956108 hasConcept C2777204577 @default.
- W4220956108 hasConcept C2778186239 @default.
- W4220956108 hasConcept C50156730 @default.
- W4220956108 hasConcept C504460877 @default.
- W4220956108 hasConcept C529278444 @default.
- W4220956108 hasConcept C71924100 @default.
- W4220956108 hasConcept C85663871 @default.
- W4220956108 hasConcept C98274493 @default.
- W4220956108 hasConceptScore W4220956108C111113717 @default.
- W4220956108 hasConceptScore W4220956108C112705442 @default.
- W4220956108 hasConceptScore W4220956108C118552586 @default.
- W4220956108 hasConceptScore W4220956108C126322002 @default.
- W4220956108 hasConceptScore W4220956108C195735259 @default.
- W4220956108 hasConceptScore W4220956108C2777056448 @default.
- W4220956108 hasConceptScore W4220956108C2777204577 @default.
- W4220956108 hasConceptScore W4220956108C2778186239 @default.
- W4220956108 hasConceptScore W4220956108C50156730 @default.
- W4220956108 hasConceptScore W4220956108C504460877 @default.
- W4220956108 hasConceptScore W4220956108C529278444 @default.
- W4220956108 hasConceptScore W4220956108C71924100 @default.
- W4220956108 hasConceptScore W4220956108C85663871 @default.
- W4220956108 hasConceptScore W4220956108C98274493 @default.
- W4220956108 hasIssue "4" @default.
- W4220956108 hasLocation W42209561081 @default.
- W4220956108 hasLocation W42209561082 @default.
- W4220956108 hasOpenAccess W4220956108 @default.
- W4220956108 hasPrimaryLocation W42209561081 @default.
- W4220956108 hasRelatedWork W1533329967 @default.