Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220956870> ?p ?o ?g. }
- W4220956870 endingPage "2270" @default.
- W4220956870 startingPage "2259" @default.
- W4220956870 abstract "Abstract Objective Examining the role of immune‐related genes (IRGs) in “driver gene negative” lung adenocarcinoma (LUAD) may provide new ideas for the treatment and study for this LUAD subgroup. We aimed to find the hub immune‐related gene pairs can stratify the risk of “driver‐gene‐negative” LUAD. Materials and Methods IRGs were identified according to ImmPort database based on RNA sequencing results of tumors and normal tissues from 46 patients with “driver gene negative” LUAD at The First Affiliated Hospital of Sun Yat‐sen University and cyclically singly paired as immune‐related gene pairs (IRGPs). Multivariate Cox analysis was used to construct an immune risk model and a prognostic nomogram combining was also been developed. Immune microenvironment landscape described by CIBERSORT and drug sensitivity calculated by pRRophetic algorithm were used to explore possible treatment improvements. Results A novel immune risk model with 5‐IRGPs (CD1A|CXCL135, CD1A|S100A7L2, IFNA7|CMTM2, IFNA7|CSF3, CAMP|TFR2) can accurately distinguish patients in the high‐ and low‐risk groups. Risk score act as an independent prognostic factor and is related to clinical stage. There are significant differences in tumor immune microenvironment and PD‐1/PD‐L1/CTLA‐4 expression between groups. The low‐risk patient may benefit more from the commonly used chemotherapy regimens such as gemcitabine and paclitaxel. Conclusion This study constructed 5‐IRGPs as a reliable prognostic tool and may represent genes pairs that are potential rationale for choice of treatment for “driver gene negative” LUAD." @default.
- W4220956870 created "2022-04-03" @default.
- W4220956870 creator A5000606171 @default.
- W4220956870 creator A5001317776 @default.
- W4220956870 creator A5024078654 @default.
- W4220956870 creator A5028090675 @default.
- W4220956870 creator A5032238886 @default.
- W4220956870 creator A5075221500 @default.
- W4220956870 creator A5076417896 @default.
- W4220956870 date "2022-03-04" @default.
- W4220956870 modified "2023-09-23" @default.
- W4220956870 title "A novel signature based on immune‐related gene pairs and clinical features to predict prognosis and treatment effect in “driver gene negative” lung adenocarcinoma" @default.
- W4220956870 cites W1994993231 @default.
- W4220956870 cites W2020335357 @default.
- W4220956870 cites W2052313621 @default.
- W4220956870 cites W2072148763 @default.
- W4220956870 cites W2075294566 @default.
- W4220956870 cites W2107092018 @default.
- W4220956870 cites W2111662961 @default.
- W4220956870 cites W2123918574 @default.
- W4220956870 cites W2129360604 @default.
- W4220956870 cites W2163774814 @default.
- W4220956870 cites W2173923142 @default.
- W4220956870 cites W2180481128 @default.
- W4220956870 cites W2292383635 @default.
- W4220956870 cites W2468543693 @default.
- W4220956870 cites W2469758901 @default.
- W4220956870 cites W2548098208 @default.
- W4220956870 cites W2560624069 @default.
- W4220956870 cites W2594607611 @default.
- W4220956870 cites W2613155082 @default.
- W4220956870 cites W2797855256 @default.
- W4220956870 cites W2898677831 @default.
- W4220956870 cites W2924584403 @default.
- W4220956870 cites W2938949698 @default.
- W4220956870 cites W2981091815 @default.
- W4220956870 cites W2992931937 @default.
- W4220956870 cites W2999417355 @default.
- W4220956870 cites W3003997538 @default.
- W4220956870 cites W3016541254 @default.
- W4220956870 cites W3017932511 @default.
- W4220956870 cites W3022631197 @default.
- W4220956870 cites W3035025780 @default.
- W4220956870 cites W3037391377 @default.
- W4220956870 cites W3037394188 @default.
- W4220956870 cites W3044744926 @default.
- W4220956870 cites W3046929678 @default.
- W4220956870 cites W3091991776 @default.
- W4220956870 cites W3093866409 @default.
- W4220956870 cites W3107791012 @default.
- W4220956870 cites W3159574453 @default.
- W4220956870 cites W3159879174 @default.
- W4220956870 cites W4220956870 @default.
- W4220956870 doi "https://doi.org/10.1002/cam4.4577" @default.
- W4220956870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35246970" @default.
- W4220956870 hasPublicationYear "2022" @default.
- W4220956870 type Work @default.
- W4220956870 citedByCount "3" @default.
- W4220956870 countsByYear W42209568702022 @default.
- W4220956870 countsByYear W42209568702023 @default.
- W4220956870 crossrefType "journal-article" @default.
- W4220956870 hasAuthorship W4220956870A5000606171 @default.
- W4220956870 hasAuthorship W4220956870A5001317776 @default.
- W4220956870 hasAuthorship W4220956870A5024078654 @default.
- W4220956870 hasAuthorship W4220956870A5028090675 @default.
- W4220956870 hasAuthorship W4220956870A5032238886 @default.
- W4220956870 hasAuthorship W4220956870A5075221500 @default.
- W4220956870 hasAuthorship W4220956870A5076417896 @default.
- W4220956870 hasBestOaLocation W42209568702 @default.
- W4220956870 hasConcept C104317684 @default.
- W4220956870 hasConcept C121608353 @default.
- W4220956870 hasConcept C126322002 @default.
- W4220956870 hasConcept C143998085 @default.
- W4220956870 hasConcept C203014093 @default.
- W4220956870 hasConcept C2776256026 @default.
- W4220956870 hasConcept C2777701055 @default.
- W4220956870 hasConcept C2780258809 @default.
- W4220956870 hasConcept C2781182431 @default.
- W4220956870 hasConcept C34626388 @default.
- W4220956870 hasConcept C502942594 @default.
- W4220956870 hasConcept C50382708 @default.
- W4220956870 hasConcept C54355233 @default.
- W4220956870 hasConcept C71924100 @default.
- W4220956870 hasConcept C86803240 @default.
- W4220956870 hasConcept C8891405 @default.
- W4220956870 hasConceptScore W4220956870C104317684 @default.
- W4220956870 hasConceptScore W4220956870C121608353 @default.
- W4220956870 hasConceptScore W4220956870C126322002 @default.
- W4220956870 hasConceptScore W4220956870C143998085 @default.
- W4220956870 hasConceptScore W4220956870C203014093 @default.
- W4220956870 hasConceptScore W4220956870C2776256026 @default.
- W4220956870 hasConceptScore W4220956870C2777701055 @default.
- W4220956870 hasConceptScore W4220956870C2780258809 @default.
- W4220956870 hasConceptScore W4220956870C2781182431 @default.
- W4220956870 hasConceptScore W4220956870C34626388 @default.
- W4220956870 hasConceptScore W4220956870C502942594 @default.
- W4220956870 hasConceptScore W4220956870C50382708 @default.
- W4220956870 hasConceptScore W4220956870C54355233 @default.