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- W4220956944 abstract "Osteosarcoma (OS) is the most common primary bone malignancy. Chemotherapy plays an essential role in OS treatment, potentially doubling 5-year event-free survival if tumour necrosis can be stimulated. The canonical Wnt inhibitor Dickkopf-1 (Dkk-1) enhances OS survival in part through upregulation of aldehyde-dehydrogenase-1A1 which neutralises reactive oxygen species originating from nutritional stress and chemotherapeutic challenge.A vivo morpholino (DkkMo) was employed to block the expression of Dkk-1 in OS cells. Cell mitosis, gene expression and bone destruction were measured in vitro and in vivo in the presence and absence of doxorubicin (DRB).DkkMo reduced the expression of Dkk-1 and Aldh1a1, reduced expansion of OS tumours, preserved bone volume and architecture and stimulated tumour necrosis. This was observed in the presence or absence of DRB.These results indicate that administration of DkkMo with or without chemotherapeutics can substantially improve OS outcome with respect to tumour expansion and osteolytic corruption of bone in experimental OS model." @default.
- W4220956944 created "2022-04-03" @default.
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- W4220956944 date "2022-03-11" @default.
- W4220956944 modified "2023-10-10" @default.
- W4220956944 title "Morpholino-driven blockade of Dkk-1 in osteosarcoma inhibits bone damage and tumour expansion by multiple mechanisms" @default.
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- W4220956944 cites W1963724799 @default.
- W4220956944 cites W1964390923 @default.
- W4220956944 cites W1965512352 @default.
- W4220956944 cites W1967558445 @default.
- W4220956944 cites W1968332094 @default.
- W4220956944 cites W1984938149 @default.
- W4220956944 cites W1988835812 @default.
- W4220956944 cites W1993465290 @default.
- W4220956944 cites W1994812668 @default.
- W4220956944 cites W1996343859 @default.
- W4220956944 cites W2006419043 @default.
- W4220956944 cites W2009140393 @default.
- W4220956944 cites W2017187301 @default.
- W4220956944 cites W2023534921 @default.
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- W4220956944 cites W2062960810 @default.
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- W4220956944 cites W2587889130 @default.
- W4220956944 cites W2616346761 @default.
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- W4220956944 doi "https://doi.org/10.1038/s41416-022-01764-z" @default.
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