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- W4220957046 abstract "Introduction: Head and neck squamous cell carcinoma (HNSCC) is a malignant neoplasm that arises in the oral cavity, nasal cavity, paranasal sinuses, oropharynx, nasopharnx, and larynx. Among various prognostic markers in HNSCC, demonstration of p16 protein expression is of great importance. Objective: To determine the frequency of p16 expression in head and neck squamous cell carcinoma by Immuno-histochemistry (IHC) in patients reporting at Rehman Medical Institute. Methodology: This was descriptive, cross sectional study piloted at the Department of Histopathology, Rehman Medical Institute (RMI) for a period of six months from 10/March/2016 to 10/September/2016. This study was carried out on a total of 103 patients diagnosed with head and neck squamous cell carcinoma. On Formalin Fixed Parafin embedded blocks of already diagnosed OSCC cases, IHC staining was done by using p16 (monoclonal) antibody on FFPE blocks of OSCC. Statistical analysis of the data was done by using the software SPSS version 20. Results: p16 was positive in 95 cases (92.2%) and negative in 8 cases (7.8%). Chi-square test was performed between p16 and site of biopsy, a significant relation was observed with P-value 0.023 (<0.05). Of all the positive cases, p16 was positive in 51 cases (53.7%) of oral cavity SCC, 17 cases (17.9%) of pharyngeal SCC, 23 cases (24.2 %) of laryngeal SCC and 4 cases (4.2%) of nasal cavity SCC. Conclusion: High expression of p16 was observed in HNSCC cases with correlation to various sites of Head and Neck. Keywords: HNSCC, p16; Prognosis, Cancer" @default.
- W4220957046 created "2022-04-03" @default.
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- W4220957046 date "2022-01-30" @default.
- W4220957046 modified "2023-10-01" @default.
- W4220957046 title "Expression of P16 in Head and Neck Squamous Cell Carcinoma" @default.
- W4220957046 doi "https://doi.org/10.53350/pjmhs221611072" @default.
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