Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220960596> ?p ?o ?g. }
- W4220960596 endingPage "629" @default.
- W4220960596 startingPage "629" @default.
- W4220960596 abstract "Neurological diseases continue to increase in prevalence worldwide. Combined with the lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a significant and growing burden on healthcare systems and societies. The development of neuroprotective or curative therapies is limited by a variety of factors, but none more than the highly selective blood-brain barrier. Intranasal administration can bypass this barrier completely and allow direct access to brain tissues, enabling a large number of potential new therapies ranging from bioactive peptides to stem cells. Current research indicates that merely administering simple solutions is inefficient and may limit therapeutic success. While many therapies can be delivered to some degree without carrier molecules or significant modification, a growing body of research has indicated several methods of improving the safety and efficacy of this administration route, such as nasal permeability enhancers, gelling agents, or nanocarrier formulations. This review shall discuss promising delivery systems and their role in expanding the clinical efficacy of this novel administration route. Optimization of intranasal administration will be crucial as novel therapies continue to be studied in clinical trials and approved to meet the growing demand for the treatment of patients with neurological diseases." @default.
- W4220960596 created "2022-04-03" @default.
- W4220960596 creator A5005446114 @default.
- W4220960596 creator A5081637944 @default.
- W4220960596 date "2022-03-12" @default.
- W4220960596 modified "2023-10-09" @default.
- W4220960596 title "Evaluation of Recent Intranasal Drug Delivery Systems to the Central Nervous System" @default.
- W4220960596 cites W1004290753 @default.
- W4220960596 cites W1540089653 @default.
- W4220960596 cites W1579046626 @default.
- W4220960596 cites W1598072106 @default.
- W4220960596 cites W1612293997 @default.
- W4220960596 cites W1967364478 @default.
- W4220960596 cites W1972165921 @default.
- W4220960596 cites W1972788278 @default.
- W4220960596 cites W1973627211 @default.
- W4220960596 cites W1974172976 @default.
- W4220960596 cites W1978506065 @default.
- W4220960596 cites W1981320103 @default.
- W4220960596 cites W1982164851 @default.
- W4220960596 cites W1983090757 @default.
- W4220960596 cites W1985530230 @default.
- W4220960596 cites W1985576902 @default.
- W4220960596 cites W1986757417 @default.
- W4220960596 cites W1987190668 @default.
- W4220960596 cites W1988188914 @default.
- W4220960596 cites W1988652094 @default.
- W4220960596 cites W1989456242 @default.
- W4220960596 cites W1992625802 @default.
- W4220960596 cites W1994294415 @default.
- W4220960596 cites W1994848292 @default.
- W4220960596 cites W1998526261 @default.
- W4220960596 cites W1999116330 @default.
- W4220960596 cites W2001525797 @default.
- W4220960596 cites W2002065049 @default.
- W4220960596 cites W2003116578 @default.
- W4220960596 cites W2003501812 @default.
- W4220960596 cites W2010859559 @default.
- W4220960596 cites W2013322977 @default.
- W4220960596 cites W2015782388 @default.
- W4220960596 cites W2016661048 @default.
- W4220960596 cites W2017692494 @default.
- W4220960596 cites W2022132405 @default.
- W4220960596 cites W2022687905 @default.
- W4220960596 cites W2027426650 @default.
- W4220960596 cites W2027635017 @default.
- W4220960596 cites W2027811581 @default.
- W4220960596 cites W2027876233 @default.
- W4220960596 cites W2029206557 @default.
- W4220960596 cites W2029519290 @default.
- W4220960596 cites W2032554316 @default.
- W4220960596 cites W2033205225 @default.
- W4220960596 cites W2033585238 @default.
- W4220960596 cites W2035726141 @default.
- W4220960596 cites W2035745039 @default.
- W4220960596 cites W2039046378 @default.
- W4220960596 cites W2041611624 @default.
- W4220960596 cites W2044682044 @default.
- W4220960596 cites W2045670750 @default.
- W4220960596 cites W2047600220 @default.
- W4220960596 cites W2051455837 @default.
- W4220960596 cites W2051575873 @default.
- W4220960596 cites W2051587828 @default.
- W4220960596 cites W2058897409 @default.
- W4220960596 cites W2058940095 @default.
- W4220960596 cites W2060393760 @default.
- W4220960596 cites W2062886175 @default.
- W4220960596 cites W2063109245 @default.
- W4220960596 cites W2064110215 @default.
- W4220960596 cites W2068304779 @default.
- W4220960596 cites W2068306536 @default.
- W4220960596 cites W2069075799 @default.
- W4220960596 cites W2071068165 @default.
- W4220960596 cites W2071133343 @default.
- W4220960596 cites W2072093696 @default.
- W4220960596 cites W2075050299 @default.
- W4220960596 cites W2076066796 @default.
- W4220960596 cites W2076378379 @default.
- W4220960596 cites W2076381752 @default.
- W4220960596 cites W2077680189 @default.
- W4220960596 cites W2077756131 @default.
- W4220960596 cites W2083337622 @default.
- W4220960596 cites W2083537472 @default.
- W4220960596 cites W2083588057 @default.
- W4220960596 cites W2086190854 @default.
- W4220960596 cites W2088082397 @default.
- W4220960596 cites W2088674577 @default.
- W4220960596 cites W2089084934 @default.
- W4220960596 cites W2090240646 @default.
- W4220960596 cites W2091483311 @default.
- W4220960596 cites W2094992588 @default.
- W4220960596 cites W2101099825 @default.
- W4220960596 cites W2102002215 @default.
- W4220960596 cites W2106536537 @default.
- W4220960596 cites W2107839728 @default.
- W4220960596 cites W2110340795 @default.
- W4220960596 cites W2110344582 @default.
- W4220960596 cites W2114179943 @default.