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- W4220962616 endingPage "5497" @default.
- W4220962616 startingPage "5480" @default.
- W4220962616 abstract "Numerous studies have exemplified the importance of nuclear factor erythroid 2-related factor 2 (Nrf2) activation in the alleviation of toxin-induced hepatic disorders primarily through eliminating oxidative stress. Whereafter, increasingly more efforts have been contributed to finding Nrf2-activators, especially from dietary polyphenols. The present review summarized the phenolic-type Nrf2-activators published in the past few decades, analyzed their effectiveness based on their structural characteristics and outlined their related mechanisms. It turns out that flavonoids are the largest group of phenolic-type Nrf2-activators, followed by nonflavonoids and phenolic acids. When counting on subgroups, the top three types are flavonols, flavones, and hydroxycinnamic acids, with curcuminoids having the highest effective doses. Moreover, most polyphenols work through the phosphorylation of Nrf2. Besides, mitogen-activated protein kinases (MAPKs) and protein kinase B (Akt) are the frequent targets of these Nrf2-activators, which indirectly mediate the behavior of Nrf2. However, current data are not sufficient to conclude any structure-activity relationship." @default.
- W4220962616 created "2022-04-03" @default.
- W4220962616 creator A5001131711 @default.
- W4220962616 creator A5021979312 @default.
- W4220962616 creator A5024685322 @default.
- W4220962616 creator A5039336343 @default.
- W4220962616 creator A5047173459 @default.
- W4220962616 creator A5048826252 @default.
- W4220962616 creator A5071275129 @default.
- W4220962616 creator A5083489326 @default.
- W4220962616 date "2022-01-01" @default.
- W4220962616 modified "2023-10-01" @default.
- W4220962616 title "Dietary phenolic-type Nrf2-activators: implications in the control of toxin-induced hepatic disorders" @default.
- W4220962616 cites W1018162543 @default.
- W4220962616 cites W1484007224 @default.
- W4220962616 cites W1526037649 @default.
- W4220962616 cites W1691027052 @default.
- W4220962616 cites W1835393201 @default.
- W4220962616 cites W1964955342 @default.
- W4220962616 cites W1964995369 @default.
- W4220962616 cites W1967312447 @default.
- W4220962616 cites W1967385215 @default.
- W4220962616 cites W1973722855 @default.
- W4220962616 cites W1974553236 @default.
- W4220962616 cites W1978472019 @default.
- W4220962616 cites W1980739328 @default.
- W4220962616 cites W1984494863 @default.
- W4220962616 cites W1985974896 @default.
- W4220962616 cites W1986387288 @default.
- W4220962616 cites W1993012909 @default.
- W4220962616 cites W1993165272 @default.
- W4220962616 cites W1993189898 @default.
- W4220962616 cites W2002015567 @default.
- W4220962616 cites W2009863034 @default.
- W4220962616 cites W2019068035 @default.
- W4220962616 cites W2022582116 @default.
- W4220962616 cites W2022806746 @default.
- W4220962616 cites W2032518149 @default.
- W4220962616 cites W2035676834 @default.
- W4220962616 cites W2043638349 @default.
- W4220962616 cites W2044217881 @default.
- W4220962616 cites W2045460284 @default.
- W4220962616 cites W2048246530 @default.
- W4220962616 cites W2050560791 @default.
- W4220962616 cites W2054733228 @default.
- W4220962616 cites W2068880725 @default.
- W4220962616 cites W2071246446 @default.
- W4220962616 cites W2080508350 @default.
- W4220962616 cites W2084263514 @default.
- W4220962616 cites W2123098050 @default.
- W4220962616 cites W2124728669 @default.
- W4220962616 cites W2140840050 @default.
- W4220962616 cites W2145212391 @default.
- W4220962616 cites W2146612164 @default.
- W4220962616 cites W2162853795 @default.
- W4220962616 cites W2167001925 @default.
- W4220962616 cites W2184073024 @default.
- W4220962616 cites W2190826983 @default.
- W4220962616 cites W2221338781 @default.
- W4220962616 cites W2287952815 @default.
- W4220962616 cites W2298567220 @default.
- W4220962616 cites W2301719074 @default.
- W4220962616 cites W2474737012 @default.
- W4220962616 cites W2500446286 @default.
- W4220962616 cites W2526497939 @default.
- W4220962616 cites W2535605637 @default.
- W4220962616 cites W2536311229 @default.
- W4220962616 cites W2551915804 @default.
- W4220962616 cites W2554313247 @default.
- W4220962616 cites W2556630670 @default.
- W4220962616 cites W2561424162 @default.
- W4220962616 cites W2572794158 @default.
- W4220962616 cites W2588219173 @default.
- W4220962616 cites W2588442940 @default.
- W4220962616 cites W2592647619 @default.
- W4220962616 cites W2600764038 @default.
- W4220962616 cites W2605106968 @default.
- W4220962616 cites W2606876974 @default.
- W4220962616 cites W2607373498 @default.
- W4220962616 cites W2617993416 @default.
- W4220962616 cites W2662182613 @default.
- W4220962616 cites W2740140793 @default.
- W4220962616 cites W2740301936 @default.
- W4220962616 cites W2765869846 @default.
- W4220962616 cites W2767475058 @default.
- W4220962616 cites W2767526444 @default.
- W4220962616 cites W2767586242 @default.
- W4220962616 cites W2768499679 @default.
- W4220962616 cites W2770535330 @default.
- W4220962616 cites W2776342909 @default.
- W4220962616 cites W2784143867 @default.
- W4220962616 cites W2785745834 @default.
- W4220962616 cites W2788457672 @default.
- W4220962616 cites W2791119282 @default.
- W4220962616 cites W2791463109 @default.
- W4220962616 cites W2792279154 @default.
- W4220962616 cites W2792596738 @default.
- W4220962616 cites W2795019013 @default.