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• W4220963012 endingPage "826" @default.
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• W4220963012 abstract "Drugs used to manage type 2 diabetes mellitus cause adverse effects. Therefore, the search for new drugs as an alternative for the treatment of diabetes increases. The effect of triterpene 3β-6β-16β-trihydroxylup-20(29)-ene isolated from the leaves of C. leprosum (CLF-1) on sucrose-induced hyperglycemia in adult zebrafish (Danio rerio) was evaluated. Initially, adult zebrafish (n = 6/group) underwent hyperglycemia induction by sucrose at 83.25 mM/L for 7 days by immersion. The hyperglycemic groups were treated with CLF-1 (4, 20, and 40 mg/kg), metformin (200 mg/kg), and acarbose (300 mg/kg) for 4 days. The in silico interaction of CLF-1, metformin, and acarbose with the enzyme maltase-glucoamylase (CtMGAM) was investigated. CLF-1 reduced sucrose-induced hyperglycemia after 4 days of treatment, in addition to having better affinity energy with CtMGAM than metformin and acarbose. Thus, CLF-1 may be a new pharmacological alternative as a hypoglycemic agent for the treatment of diabetes." @default.
• W4220963012 created "2022-04-03" @default.
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• W4220963012 date "2022-03-14" @default.
• W4220963012 modified "2023-09-27" @default.
• W4220963012 title "Hypoglycemic effect on adult zebrafish ( <scp> <i>Danio rerio</i> </scp> ) of the 3β‐6β‐16β‐trihydroxylup‐20(29)‐ene triterpene isolated from <i>Combretum leprosum</i> leaves in vivo and in silico approach" @default.
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• W4220963012 doi "https://doi.org/10.1111/fcp.12776" @default.
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