FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220963478> ?p ?o ?g. }

• W4220963478 endingPage "179" @default.
• W4220963478 startingPage "168" @default.
• W4220963478 abstract "Objective Alcoholic hepatitis (AH) reflects acute exacerbation of alcoholic liver disease (ALD) and is a growing healthcare burden worldwide. Interleukin-11 (IL-11) is a profibrotic, proinflammatory cytokine with increasingly recognised toxicities in parenchymal and epithelial cells. We explored IL-11 serum levels and their prognostic value in patients suffering from AH and cirrhosis of various aetiology and experimental ALD. Design IL-11 serum concentration and tissue expression was determined in a cohort comprising 50 patients with AH, 110 patients with cirrhosis and 19 healthy volunteers. Findings were replicated in an independent patient cohort (n=186). Primary human hepatocytes exposed to ethanol were studied in vitro. Ethanol-fed wildtype mice were treated with a neutralising murine IL-11 receptor-antibody (anti-IL11RA) and examined for severity signs and markers of ALD. Results IL-11 serum concentration and hepatic expression increased with severity of liver disease, mostly pronounced in AH. In a multivariate Cox-regression, a serum level above 6.4 pg/mL was a model of end-stage liver disease independent risk factor for transplant-free survival in patients with compensated and decompensated cirrhosis. In mice, severity of alcohol-induced liver inflammation correlated with enhanced hepatic IL-11 and IL11RA expression. In vitro and in vivo, anti-IL11RA reduced pathogenic signalling pathways (extracellular signal-regulated kinases, c-Jun N-terminal kinase, NADPH oxidase 4) and protected hepatocytes and murine livers from ethanol-induced inflammation and injury. Conclusion Pathogenic IL-11 signalling in hepatocytes plays a crucial role in the pathogenesis of ALD and could serve as an independent prognostic factor for transplant-free survival. Blocking IL-11 signalling might be a therapeutic option in human ALD, particularly AH." @default.
• W4220963478 created "2022-04-03" @default.
• W4220963478 creator A5002129702 @default.
• W4220963478 creator A5002243784 @default.
• W4220963478 creator A5008968383 @default.
• W4220963478 creator A5011019121 @default.
• W4220963478 creator A5011180629 @default.
• W4220963478 creator A5011788828 @default.
• W4220963478 creator A5013439619 @default.
• W4220963478 creator A5018258721 @default.
• W4220963478 creator A5023434480 @default.
• W4220963478 creator A5036264788 @default.
• W4220963478 creator A5043360456 @default.
• W4220963478 creator A5046705548 @default.
• W4220963478 creator A5047410049 @default.
• W4220963478 creator A5048590032 @default.
• W4220963478 creator A5050626665 @default.
• W4220963478 creator A5058422174 @default.
• W4220963478 creator A5064796848 @default.
• W4220963478 creator A5066016541 @default.
• W4220963478 creator A5071216592 @default.
• W4220963478 creator A5084751312 @default.
• W4220963478 creator A5085269219 @default.
• W4220963478 creator A5088680222 @default.
• W4220963478 creator A5089649509 @default.
• W4220963478 creator A5091593739 @default.
• W4220963478 creator A5091751081 @default.
• W4220963478 date "2022-04-01" @default.
• W4220963478 modified "2023-10-07" @default.
• W4220963478 title "Interleukin-11 drives human and mouse alcohol-related liver disease" @default.
• W4220963478 cites W1969234034 @default.
• W4220963478 cites W2017851289 @default.
• W4220963478 cites W2024933805 @default.
• W4220963478 cites W2031535859 @default.
• W4220963478 cites W2054102335 @default.
• W4220963478 cites W2059714773 @default.
• W4220963478 cites W2060637877 @default.
• W4220963478 cites W2111997581 @default.
• W4220963478 cites W2151846621 @default.
• W4220963478 cites W2165470159 @default.
• W4220963478 cites W2253819322 @default.
• W4220963478 cites W2286042547 @default.
• W4220963478 cites W2291262197 @default.
• W4220963478 cites W2314673390 @default.
• W4220963478 cites W267567551 @default.
• W4220963478 cites W2770331207 @default.
• W4220963478 cites W2802906787 @default.
• W4220963478 cites W2884236054 @default.
• W4220963478 cites W2889517514 @default.
• W4220963478 cites W2893835498 @default.
• W4220963478 cites W2913529349 @default.
• W4220963478 cites W2943943349 @default.
• W4220963478 cites W2948156616 @default.
• W4220963478 cites W2975410560 @default.
• W4220963478 cites W2998313718 @default.
• W4220963478 cites W3003988544 @default.
• W4220963478 cites W3009225573 @default.
• W4220963478 cites W3035637159 @default.
• W4220963478 cites W3042767436 @default.
• W4220963478 cites W3044007297 @default.
• W4220963478 cites W3112017976 @default.
• W4220963478 cites W3120424692 @default.
• W4220963478 cites W3130594016 @default.
• W4220963478 cites W3169002084 @default.
• W4220963478 cites W4210980460 @default.
• W4220963478 cites W71591707 @default.
• W4220963478 cites W9379707 @default.
• W4220963478 doi "https://doi.org/10.1136/gutjnl-2021-326076" @default.
• W4220963478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35365572" @default.
• W4220963478 hasPublicationYear "2022" @default.
• W4220963478 type Work @default.
• W4220963478 citedByCount "5" @default.
• W4220963478 countsByYear W42209634782022 @default.
• W4220963478 countsByYear W42209634782023 @default.
• W4220963478 crossrefType "journal-article" @default.
• W4220963478 hasAuthorship W4220963478A5002129702 @default.
• W4220963478 hasAuthorship W4220963478A5002243784 @default.
• W4220963478 hasAuthorship W4220963478A5008968383 @default.
• W4220963478 hasAuthorship W4220963478A5011019121 @default.
• W4220963478 hasAuthorship W4220963478A5011180629 @default.
• W4220963478 hasAuthorship W4220963478A5011788828 @default.
• W4220963478 hasAuthorship W4220963478A5013439619 @default.
• W4220963478 hasAuthorship W4220963478A5018258721 @default.
• W4220963478 hasAuthorship W4220963478A5023434480 @default.
• W4220963478 hasAuthorship W4220963478A5036264788 @default.
• W4220963478 hasAuthorship W4220963478A5043360456 @default.
• W4220963478 hasAuthorship W4220963478A5046705548 @default.
• W4220963478 hasAuthorship W4220963478A5047410049 @default.
• W4220963478 hasAuthorship W4220963478A5048590032 @default.
• W4220963478 hasAuthorship W4220963478A5050626665 @default.
• W4220963478 hasAuthorship W4220963478A5058422174 @default.
• W4220963478 hasAuthorship W4220963478A5064796848 @default.
• W4220963478 hasAuthorship W4220963478A5066016541 @default.
• W4220963478 hasAuthorship W4220963478A5071216592 @default.
• W4220963478 hasAuthorship W4220963478A5084751312 @default.
• W4220963478 hasAuthorship W4220963478A5085269219 @default.
• W4220963478 hasAuthorship W4220963478A5088680222 @default.
• W4220963478 hasAuthorship W4220963478A5089649509 @default.

• next