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- W4220963518 abstract "Oxidative stress plays significant roles in the development of various diseases. H2O2 acts as a signaling molecule physiologically or harmful substance pathologically and the mitochondria are one of the most active places for the generation of H2O2. Thus, a new mitochondria-targeted probe 1 for H2O2 detection was synthesized herein, based on D-π-A structure with a large Stokes shift (150 nm) due to its ICT process. To improve its water solubility and sensitivity, probe 2 with PEG chain and probe 3 with two responsive boronated groups were then designed based on the structure of probe 1. As a result, the fluorescence intensity of probe 2 was far higher than that of probe 1 and probe 3 not only in vitro experiment but in cell imaging study with a larger linear range and signal-to-noise ratio, rendering it the best probe for further exogenous and endogenous H2O2 detection in Hela cells." @default.
- W4220963518 created "2022-04-03" @default.
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- W4220963518 date "2022-06-01" @default.
- W4220963518 modified "2023-09-29" @default.
- W4220963518 title "PEGylated near-infrared fluorescence probe for mitochondria-targetable hydrogen peroxide detection" @default.
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- W4220963518 doi "https://doi.org/10.1016/j.talanta.2022.123370" @default.
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