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- W4220967981 abstract "Abstract Background The two subspecies of Bifidobacterium catenulatum , B. catenulatum subsp. kashiwanohense and B. catenulatum subsp. catenulatum , are usually from the infant and adult gut, respectively. However, the genomic analysis of their functional difference and genetic divergence has been rare. Here, 16 B. catenulatum strains, including 2 newly sequenced strains, were analysed through comparative genomics. A phylogenetic tree based on 785 core genes indicated that the two subspecies were significantly divergent. Results A phylogenetic tree based on 785 core genes indicated that the two subspecies of B. catenulatum were significantly separated. The comparison of genomic characteristics revealed that the two subspecies had significantly different genomic sizes ( p <0.05) but similar GC contents. The functional comparison revealed the most significant difference in carbohydrate utilisation. Carbohydrate-active enzymes (CAZyme) present two clustering patterns in B. catenulatum. The B. catenulatum subsp. kashiwanohense specially including the glycoside hydrolases 95 (GH95) and carbohydrate-binding modules 51 (CBM51) families involved in the metabolism of human milk oligosaccharides (HMO) common in infants, also, the corresponding fucosylated HMO gene clusters were detected. Meanwhile, B. catenulatum subsp. catenulatum rich in GH3 may metabolise more plant-derived glycan in the adult intestine. Conclusions These findings provide genomic evidence of carbohydrate utilisation bias, which may be a key cause of the genetic divergence of two B. catenulatum subspecies." @default.
- W4220967981 created "2022-04-03" @default.
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- W4220967981 date "2022-02-03" @default.
- W4220967981 modified "2023-09-26" @default.
- W4220967981 title "Comparative Genomic Analysis of Bifidobacterium Catenulatum Reveal the Genetic Divergence of its Two Subspecies from Infant and Adult Gut" @default.
- W4220967981 doi "https://doi.org/10.21203/rs.3.rs-957925/v2" @default.
- W4220967981 hasPublicationYear "2022" @default.
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