FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220970037> ?p ?o ?g. }

• W4220970037 endingPage "576" @default.
• W4220970037 startingPage "564" @default.
• W4220970037 abstract "Abstract Aims To date, stroke remains one of the leading causes of death and disability worldwide. Nearly three-quarters of all strokes occur in the elderly (&gt;65 years old), and a vast majority of these individuals develop debilitating cognitive impairments that can later progress into dementia. Currently, there are no therapies capable of reversing the cognitive complications which arise following a stroke. Instead, current treatment options focus on preventing secondary injuries, as opposed to improving functional recovery. Methods We reconstituted aged (20-month old) mice with Sca-1+ bone marrow (BM) hematopoietic stem cells isolated from aged or young (2-month old) EGFP+ donor mice. Three months later the chimeric aged mice underwent cerebral ischemia/reperfusion by bilateral common carotid artery occlusion (BCCAO), after which cognitive function was evaluated. Immunohistochemical analysis was performed to evaluate host and recipient cells in the brain following BCCAO. Results Young Sca-1+ cells migrate to the aged brain and give rise to beneficial microglial-like cells that ameliorate stroke-induced loss of cognitive function on tasks targeting the hippocampus and cerebellum. We also found that young Sca-1+ cell-derived microglial-like cells possess neuroprotective properties as they do not undergo microgliosis upon migrating to the ischemic hippocampus, whereas the cells originating from old Sca-1+ cells proliferate extensively and skew toward a pro-inflammatory phenotype following injury. Conclusions This study provides a proof-of-principle demonstrating that young BM Sca-1+ cells play a pivotal role in reversing stroke-induced cognitive impairments and protect the aged brain against secondary injury by attenuating the host cell response to injury." @default.
• W4220970037 created "2022-04-03" @default.
• W4220970037 creator A5017496726 @default.
• W4220970037 creator A5047937368 @default.
• W4220970037 creator A5051615750 @default.
• W4220970037 creator A5071798015 @default.
• W4220970037 creator A5087765402 @default.
• W4220970037 date "2022-03-15" @default.
• W4220970037 modified "2023-09-24" @default.
• W4220970037 title "Stroke-Induced Neurological Dysfunction in Aged Mice Is Attenuated by Preconditioning with Young Sca-1+ Stem Cells" @default.
• W4220970037 cites W1590854724 @default.
• W4220970037 cites W1834172848 @default.
• W4220970037 cites W1900057632 @default.
• W4220970037 cites W1934207236 @default.
• W4220970037 cites W1963721982 @default.
• W4220970037 cites W1969905245 @default.
• W4220970037 cites W1974294728 @default.
• W4220970037 cites W1978927200 @default.
• W4220970037 cites W1982034065 @default.
• W4220970037 cites W1989025584 @default.
• W4220970037 cites W1995805913 @default.
• W4220970037 cites W2001457444 @default.
• W4220970037 cites W2003438800 @default.
• W4220970037 cites W2007981533 @default.
• W4220970037 cites W2008639289 @default.
• W4220970037 cites W2013743080 @default.
• W4220970037 cites W2024661673 @default.
• W4220970037 cites W2024868951 @default.
• W4220970037 cites W2027941907 @default.
• W4220970037 cites W2030218753 @default.
• W4220970037 cites W2032227357 @default.
• W4220970037 cites W2040319474 @default.
• W4220970037 cites W2046844548 @default.
• W4220970037 cites W2048171351 @default.
• W4220970037 cites W2051504363 @default.
• W4220970037 cites W2059109913 @default.
• W4220970037 cites W2063629303 @default.
• W4220970037 cites W2071680171 @default.
• W4220970037 cites W2073391734 @default.
• W4220970037 cites W2097971052 @default.
• W4220970037 cites W2102485957 @default.
• W4220970037 cites W2103420764 @default.
• W4220970037 cites W2105112344 @default.
• W4220970037 cites W2106105150 @default.
• W4220970037 cites W2107575355 @default.
• W4220970037 cites W2113107925 @default.
• W4220970037 cites W2127845947 @default.
• W4220970037 cites W2130198578 @default.
• W4220970037 cites W2136879502 @default.
• W4220970037 cites W2144063270 @default.
• W4220970037 cites W2156589853 @default.
• W4220970037 cites W2157622195 @default.
• W4220970037 cites W2165801811 @default.
• W4220970037 cites W2262503792 @default.
• W4220970037 cites W2292956350 @default.
• W4220970037 cites W2517858288 @default.
• W4220970037 cites W2584577396 @default.
• W4220970037 cites W2592956742 @default.
• W4220970037 cites W2765444777 @default.
• W4220970037 cites W2783155924 @default.
• W4220970037 cites W2790132888 @default.
• W4220970037 cites W2790972620 @default.
• W4220970037 cites W2791171014 @default.
• W4220970037 cites W2791453970 @default.
• W4220970037 cites W2793751596 @default.
• W4220970037 cites W2797384836 @default.
• W4220970037 cites W2802167882 @default.
• W4220970037 cites W2804015886 @default.
• W4220970037 cites W2808470406 @default.
• W4220970037 cites W2892736527 @default.
• W4220970037 cites W2898520750 @default.
• W4220970037 cites W2916213038 @default.
• W4220970037 cites W2944611348 @default.
• W4220970037 cites W2966588009 @default.
• W4220970037 cites W2989488571 @default.
• W4220970037 cites W3005450537 @default.
• W4220970037 cites W3006699875 @default.
• W4220970037 cites W3010082761 @default.
• W4220970037 cites W3026206677 @default.
• W4220970037 cites W3039098294 @default.
• W4220970037 cites W3120998555 @default.
• W4220970037 cites W3124244005 @default.
• W4220970037 cites W3157062134 @default.
• W4220970037 cites W3164548320 @default.
• W4220970037 cites W4200608597 @default.
• W4220970037 cites W91759383 @default.
• W4220970037 doi "https://doi.org/10.1093/stmcls/sxac019" @default.
• W4220970037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35291015" @default.
• W4220970037 hasPublicationYear "2022" @default.
• W4220970037 type Work @default.
• W4220970037 citedByCount "3" @default.
• W4220970037 countsByYear W42209700372022 @default.
• W4220970037 countsByYear W42209700372023 @default.
• W4220970037 crossrefType "journal-article" @default.
• W4220970037 hasAuthorship W4220970037A5017496726 @default.
• W4220970037 hasAuthorship W4220970037A5047937368 @default.
• W4220970037 hasAuthorship W4220970037A5051615750 @default.
• W4220970037 hasAuthorship W4220970037A5071798015 @default.

• next