Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220970457> ?p ?o ?g. }
- W4220970457 endingPage "634" @default.
- W4220970457 startingPage "634" @default.
- W4220970457 abstract "Pathogenesis of viral infections of the central nervous system (CNS) is poorly understood, and this is partly due to the limitations of currently used preclinical models. Brain organoid models can overcome some of these limitations, as they are generated from human derived stem cells, differentiated in three dimensions (3D), and can mimic human neurodevelopmental characteristics. Therefore, brain organoids have been increasingly used as brain models in research on various viruses, such as Zika virus, severe acute respiratory syndrome coronavirus 2, human cytomegalovirus, and herpes simplex virus. Brain organoids allow for the study of viral tropism, the effect of infection on organoid function, size, and cytoarchitecture, as well as innate immune response; therefore, they provide valuable insight into the pathogenesis of neurotropic viral infections and testing of antivirals in a physiological model. In this review, we summarize the results of studies on viral CNS infection in brain organoids, and we demonstrate the broad application and benefits of using a human 3D model in virology research. At the same time, we describe the limitations of the studies in brain organoids, such as the heterogeneity in organoid generation protocols and age at infection, which result in differences in results between studies, as well as the lack of microglia and a blood brain barrier." @default.
- W4220970457 created "2022-04-03" @default.
- W4220970457 creator A5005175159 @default.
- W4220970457 creator A5024133138 @default.
- W4220970457 creator A5058429442 @default.
- W4220970457 creator A5060500094 @default.
- W4220970457 creator A5067789894 @default.
- W4220970457 creator A5080522312 @default.
- W4220970457 creator A5086076358 @default.
- W4220970457 creator A5087543396 @default.
- W4220970457 date "2022-03-18" @default.
- W4220970457 modified "2023-10-01" @default.
- W4220970457 title "Human Brain Organoids as Models for Central Nervous System Viral Infection" @default.
- W4220970457 cites W1545235721 @default.
- W4220970457 cites W1553983967 @default.
- W4220970457 cites W1999191464 @default.
- W4220970457 cites W2018286352 @default.
- W4220970457 cites W2060484494 @default.
- W4220970457 cites W2067267561 @default.
- W4220970457 cites W2144052741 @default.
- W4220970457 cites W2280490150 @default.
- W4220970457 cites W2289704315 @default.
- W4220970457 cites W2311770845 @default.
- W4220970457 cites W2341041396 @default.
- W4220970457 cites W2346484133 @default.
- W4220970457 cites W2356757232 @default.
- W4220970457 cites W2360131028 @default.
- W4220970457 cites W2471701648 @default.
- W4220970457 cites W2514790758 @default.
- W4220970457 cites W2537485980 @default.
- W4220970457 cites W2547682343 @default.
- W4220970457 cites W2559721763 @default.
- W4220970457 cites W2565974502 @default.
- W4220970457 cites W2569913531 @default.
- W4220970457 cites W2572997664 @default.
- W4220970457 cites W2580419078 @default.
- W4220970457 cites W2598033793 @default.
- W4220970457 cites W2738095712 @default.
- W4220970457 cites W2748279491 @default.
- W4220970457 cites W2753168648 @default.
- W4220970457 cites W2755766735 @default.
- W4220970457 cites W2761945803 @default.
- W4220970457 cites W2766824403 @default.
- W4220970457 cites W2767267170 @default.
- W4220970457 cites W2776781596 @default.
- W4220970457 cites W2784363986 @default.
- W4220970457 cites W2785609339 @default.
- W4220970457 cites W2793026191 @default.
- W4220970457 cites W2793152989 @default.
- W4220970457 cites W2797953889 @default.
- W4220970457 cites W2808156190 @default.
- W4220970457 cites W2883719087 @default.
- W4220970457 cites W2892176530 @default.
- W4220970457 cites W2895538826 @default.
- W4220970457 cites W2898613835 @default.
- W4220970457 cites W2902611822 @default.
- W4220970457 cites W2904098777 @default.
- W4220970457 cites W2905157186 @default.
- W4220970457 cites W2916061513 @default.
- W4220970457 cites W2917329184 @default.
- W4220970457 cites W2921128096 @default.
- W4220970457 cites W2926954921 @default.
- W4220970457 cites W2938519320 @default.
- W4220970457 cites W2942932095 @default.
- W4220970457 cites W2951350064 @default.
- W4220970457 cites W2952938944 @default.
- W4220970457 cites W2972826064 @default.
- W4220970457 cites W2987240580 @default.
- W4220970457 cites W2999189773 @default.
- W4220970457 cites W3013328750 @default.
- W4220970457 cites W3016127017 @default.
- W4220970457 cites W3030896070 @default.
- W4220970457 cites W3033277640 @default.
- W4220970457 cites W3037368719 @default.
- W4220970457 cites W3039825645 @default.
- W4220970457 cites W3047070253 @default.
- W4220970457 cites W3081536095 @default.
- W4220970457 cites W3081942647 @default.
- W4220970457 cites W3082172843 @default.
- W4220970457 cites W3084394739 @default.
- W4220970457 cites W3087016663 @default.
- W4220970457 cites W3087103626 @default.
- W4220970457 cites W3093313806 @default.
- W4220970457 cites W3093347896 @default.
- W4220970457 cites W3093979528 @default.
- W4220970457 cites W3095271748 @default.
- W4220970457 cites W3109542671 @default.
- W4220970457 cites W3110045240 @default.
- W4220970457 cites W3112727516 @default.
- W4220970457 cites W3113458214 @default.
- W4220970457 cites W3117551966 @default.
- W4220970457 cites W3118627743 @default.
- W4220970457 cites W3118806519 @default.
- W4220970457 cites W3122277353 @default.
- W4220970457 cites W3126700647 @default.
- W4220970457 cites W3128142873 @default.
- W4220970457 cites W3129671014 @default.
- W4220970457 cites W3135137033 @default.