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- W4220972021 abstract "The healthcare industry emits significant amounts of CO2 and has an imperative need for decarbonization. This study demonstrated a new hybrid electro-enzymatic process that converts waste CO2 into high-value C6 pharmaceutical precursor compounds. A novel three-chamber electrolyzer equipped with a Cu-based gas diffusion electrode converted gaseous CO2 into ethanol at a high current density (40–60 mA/cm2), high selectivity (43–81 mol %), and production rate (368–428 mg/L/h). Purified ethanol from the electrolyzer was then sent to an enzymatic bioreactor where ADH and DERA enzymes upgraded ethanol into C6 statin precursor molecules at high yields (29–35%) via acetaldehyde. Competitive C6 lactol synthesis rates (4.7–5.7 mM/day) and titers (712–752 mg/L) were achieved, demonstrating the potential of the end-to-end process. The C6 lactol product can seamlessly be converted to statins, a class of lipid-lowering medication that is among the largest selling class of drugs in the world. This hybrid process provides a new pathway for CO2 valorization to high-value products and accelerates healthcare sector decarbonization." @default.
- W4220972021 created "2022-04-03" @default.
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- W4220972021 date "2022-03-22" @default.
- W4220972021 modified "2023-10-14" @default.
- W4220972021 title "Cell-Free CO<sub>2</sub> Valorization to C6 Pharmaceutical Precursors via a Novel Electro-Enzymatic Process" @default.
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- W4220972021 doi "https://doi.org/10.1021/acssuschemeng.1c06746" @default.
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