Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220974160> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4220974160 abstract "Background: Minor gynaecological procedures are usually done in outpatient settings. Early discharge with minimal haemodynamic compromise is an essential requirement of these procedures. Many sedative drugs are being used for outpatient surgeries. Of the sedative agents available, dexmedetomidine, which has sedative and analgesic sparing effects, has the best safety profile in the cardiorespiratory system. Therefore, we evaluated the optimum dexmedetomidine dose for providing better procedural sedation. Methodology: This randomized, double-blinded study included 120 ASA grade I and II patients aged 18-45 years who were undergoing short gynaecological procedures in a tertiary care hospital. Patients were randomly allocated into three groups of 40 each. After a loading dose of 1 µg/kg over 10 min, group A received dexmedetomidine infusion at a rate of 0.2 µg/kg/hr, group B at a rate of 0.4 µg/kg/hr, and group C at a rate of 0.6 µg/kg/hr. Perioperative hemodynamic changes, intraoperative adjuvant drug requirements, and postoperative recovery were also compared in the three different dexmedetomidine groups. Results: Heart rate, blood pressure, oxygen saturation, and respiratory rate remained within the normal physiological range in all three groups at most perioperative time points. The time to achieve the Modified Aldrete Score and the post-anesthetic discharge scoring system was maximum in group C and minimum in group A. Ketamine had to be supplemented in almost half of the patients in group A and less than a quarter of the patients in group B. In group C, surgery was completed without any drug supplementation. Two patients in group B and four patients in group C had an episode of bradycardia. Oxygen saturation decreased in one patient in group C, necessitating oxygen supplementation. Conclusions: Dexmedetomidine, at a dose of 0.4 µg/kg/hr with ketamine supplementation, provides the most appropriate procedural sedation and analgesia (PSA) without any significant hemodynamic compromise." @default.
- W4220974160 created "2022-04-03" @default.
- W4220974160 creator A5027141789 @default.
- W4220974160 creator A5029517329 @default.
- W4220974160 creator A5074057964 @default.
- W4220974160 creator A5085158077 @default.
- W4220974160 date "2022-03-19" @default.
- W4220974160 modified "2023-10-05" @default.
- W4220974160 title "A Randomized Control Trial of Three Intravenous Dexmedetomidine Doses for Procedural Sedation in Patients Undergoing Minor Gynaecological Surgery" @default.
- W4220974160 cites W1882401998 @default.
- W4220974160 cites W1965022489 @default.
- W4220974160 cites W1968110873 @default.
- W4220974160 cites W1971101248 @default.
- W4220974160 cites W1973798824 @default.
- W4220974160 cites W1990997597 @default.
- W4220974160 cites W1991374375 @default.
- W4220974160 cites W1994981554 @default.
- W4220974160 cites W2014862451 @default.
- W4220974160 cites W2016394061 @default.
- W4220974160 cites W2021603865 @default.
- W4220974160 cites W2025499314 @default.
- W4220974160 cites W2041322579 @default.
- W4220974160 cites W2055093636 @default.
- W4220974160 cites W2065737200 @default.
- W4220974160 cites W2116775674 @default.
- W4220974160 cites W2118303527 @default.
- W4220974160 cites W2125134115 @default.
- W4220974160 cites W2167723635 @default.
- W4220974160 cites W2168312394 @default.
- W4220974160 cites W2171965597 @default.
- W4220974160 cites W2177367281 @default.
- W4220974160 cites W2886804995 @default.
- W4220974160 cites W2988925753 @default.
- W4220974160 doi "https://doi.org/10.7759/cureus.23309" @default.
- W4220974160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35464558" @default.
- W4220974160 hasPublicationYear "2022" @default.
- W4220974160 type Work @default.
- W4220974160 citedByCount "0" @default.
- W4220974160 crossrefType "journal-article" @default.
- W4220974160 hasAuthorship W4220974160A5027141789 @default.
- W4220974160 hasAuthorship W4220974160A5029517329 @default.
- W4220974160 hasAuthorship W4220974160A5074057964 @default.
- W4220974160 hasAuthorship W4220974160A5085158077 @default.
- W4220974160 hasBestOaLocation W42209741601 @default.
- W4220974160 hasConcept C126322002 @default.
- W4220974160 hasConcept C141071460 @default.
- W4220974160 hasConcept C168563851 @default.
- W4220974160 hasConcept C2776814716 @default.
- W4220974160 hasConcept C2777602617 @default.
- W4220974160 hasConcept C2777953023 @default.
- W4220974160 hasConcept C2780820201 @default.
- W4220974160 hasConcept C2781302539 @default.
- W4220974160 hasConcept C31174226 @default.
- W4220974160 hasConcept C42219234 @default.
- W4220974160 hasConcept C71924100 @default.
- W4220974160 hasConcept C84393581 @default.
- W4220974160 hasConceptScore W4220974160C126322002 @default.
- W4220974160 hasConceptScore W4220974160C141071460 @default.
- W4220974160 hasConceptScore W4220974160C168563851 @default.
- W4220974160 hasConceptScore W4220974160C2776814716 @default.
- W4220974160 hasConceptScore W4220974160C2777602617 @default.
- W4220974160 hasConceptScore W4220974160C2777953023 @default.
- W4220974160 hasConceptScore W4220974160C2780820201 @default.
- W4220974160 hasConceptScore W4220974160C2781302539 @default.
- W4220974160 hasConceptScore W4220974160C31174226 @default.
- W4220974160 hasConceptScore W4220974160C42219234 @default.
- W4220974160 hasConceptScore W4220974160C71924100 @default.
- W4220974160 hasConceptScore W4220974160C84393581 @default.
- W4220974160 hasLocation W42209741601 @default.
- W4220974160 hasLocation W42209741602 @default.
- W4220974160 hasLocation W42209741603 @default.
- W4220974160 hasOpenAccess W4220974160 @default.
- W4220974160 hasPrimaryLocation W42209741601 @default.
- W4220974160 hasRelatedWork W2110127181 @default.
- W4220974160 hasRelatedWork W2120816277 @default.
- W4220974160 hasRelatedWork W2341116565 @default.
- W4220974160 hasRelatedWork W2367312788 @default.
- W4220974160 hasRelatedWork W2373185700 @default.
- W4220974160 hasRelatedWork W2393876425 @default.
- W4220974160 hasRelatedWork W2523328379 @default.
- W4220974160 hasRelatedWork W2604185023 @default.
- W4220974160 hasRelatedWork W3029978552 @default.
- W4220974160 hasRelatedWork W4241828112 @default.
- W4220974160 isParatext "false" @default.
- W4220974160 isRetracted "false" @default.
- W4220974160 workType "article" @default.