Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220981788> ?p ?o ?g. }
- W4220981788 abstract "Pleiotropic transcription regulator RNA polymerase II (Pol II)-associated factor 1 (PAF1) governs multiple transcriptional steps and the deposition of several epigenetic marks. However, it remains unclear how ultimate transcriptional outcome is determined by PAF1 and whether it relates to PAF1-controlled epigenetic marks. We use rapid degradation systems and reveal direct PAF1 functions in governing pausing partially by recruiting Integrator-PP2A (INTAC), in addition to ensuring elongation. Following acute PAF1 degradation, most destabilized polymerase undergoes effective release, which presumably relies on skewed balance between INTAC and P-TEFb, resulting in hyperphosphorylated substrates including SPT5. Impaired Pol II progression during elongation, along with altered pause release frequency, determines the final transcriptional outputs. Moreover, PAF1 degradation causes a cumulative decline in histone modifications. These epigenetic alterations in chromatin likely further influence the production of transcripts from PAF1 target genes." @default.
- W4220981788 created "2022-04-03" @default.
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- W4220981788 date "2022-04-01" @default.
- W4220981788 modified "2023-10-16" @default.
- W4220981788 title "Coordinated regulation of RNA polymerase II pausing and elongation progression by PAF1" @default.
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