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- W4220982805 abstract "Abstract Post-translational modifications diversify protein functions and dynamically coordinate their signalling networks, influencing most aspects of cell physiology. Nevertheless, their genetic regulation or influence on complex traits is not fully understood. Here, we compare the genetic regulation of the same PTM of two proteins – glycosylation of transferrin and immunoglobulin G (IgG). By performing genome-wide association analysis of transferrin glycosylation, we identify 10 significantly associated loci, 9 of which were not reported previously. Comparing these with IgG glycosylation-associated genes, we note protein-specific associations with genes encoding glycosylation enzymes (transferrin - MGAT5 , ST3GAL4 , B3GAT1 ; IgG - MGAT3 , ST6GAL1 ), as well as shared associations ( FUT6 , FUT8 ). Colocalisation analyses of the latter suggest that different causal variants in the FUT genes regulate fucosylation of the two proteins. Glycosylation of these proteins is thus genetically regulated by both shared and protein-specific mechanisms." @default.
- W4220982805 created "2022-04-03" @default.
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- W4220982805 date "2022-03-24" @default.
- W4220982805 modified "2023-10-15" @default.
- W4220982805 title "Genetic regulation of post-translational modification of two distinct proteins" @default.
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- W4220982805 cites W2013853442 @default.
- W4220982805 cites W2015563963 @default.
- W4220982805 cites W2018838463 @default.
- W4220982805 cites W2025289680 @default.
- W4220982805 cites W2030068202 @default.
- W4220982805 cites W2030513162 @default.
- W4220982805 cites W2058178814 @default.
- W4220982805 cites W2060248602 @default.
- W4220982805 cites W2068351971 @default.
- W4220982805 cites W2073836327 @default.
- W4220982805 cites W2088990426 @default.
- W4220982805 cites W2099085143 @default.
- W4220982805 cites W2104785679 @default.
- W4220982805 cites W2107665951 @default.
- W4220982805 cites W2128316367 @default.
- W4220982805 cites W2133520037 @default.
- W4220982805 cites W2135199713 @default.
- W4220982805 cites W2136722035 @default.
- W4220982805 cites W2143431207 @default.
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- W4220982805 cites W2153533315 @default.
- W4220982805 cites W2154100133 @default.
- W4220982805 cites W2154102361 @default.
- W4220982805 cites W2238271553 @default.
- W4220982805 cites W2311800161 @default.
- W4220982805 cites W2328393125 @default.
- W4220982805 cites W2398690791 @default.
- W4220982805 cites W2401247770 @default.
- W4220982805 cites W2417483443 @default.
- W4220982805 cites W2511515754 @default.
- W4220982805 cites W2521580106 @default.
- W4220982805 cites W2564893946 @default.
- W4220982805 cites W2596270747 @default.
- W4220982805 cites W2609693581 @default.
- W4220982805 cites W2622369154 @default.
- W4220982805 cites W2749039461 @default.
- W4220982805 cites W2750945087 @default.
- W4220982805 cites W2770092353 @default.
- W4220982805 cites W2787237920 @default.
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- W4220982805 cites W2789884739 @default.
- W4220982805 cites W2805983714 @default.
- W4220982805 cites W2807901568 @default.
- W4220982805 cites W2874277599 @default.
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- W4220982805 cites W2895486342 @default.
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- W4220982805 cites W2949616733 @default.
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- W4220982805 cites W3048245060 @default.
- W4220982805 cites W3083392911 @default.
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- W4220982805 doi "https://doi.org/10.1038/s41467-022-29189-5" @default.
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- W4220982805 hasPublicationYear "2022" @default.
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