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- W4220983882 abstract "Abstract Anxiety disorders are complex diseases, and often co-occur with depression. It is as yet unclear if a common neural circuit controls anxiety-related behaviors in both anxiety-alone and comorbid conditions. Here, utilizing the chronic social defeat stress (CSDS) paradigm that induces singular or combined anxiety- and depressive-like phenotypes in mice, we show that a ventral tegmental area (VTA) dopamine circuit projecting to the basolateral amygdala (BLA) selectively controls anxiety- but not depression-like behaviors. Using circuit-dissecting ex vivo electrophysiology and in vivo fiber photometry approaches, we establish that expression of anxiety-like, but not depressive-like, phenotypes are negatively correlated with VTA → BLA dopamine neuron activity. Further, our optogenetic studies demonstrate a causal link between such neuronal activity and anxiety-like behaviors. Overall, these data establish a functional role for VTA → BLA dopamine neurons in bi-directionally controlling anxiety-related behaviors not only in anxiety-alone, but also in anxiety-depressive comorbid conditions in mice." @default.
- W4220983882 created "2022-04-03" @default.
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- W4220983882 date "2022-03-22" @default.
- W4220983882 modified "2023-10-18" @default.
- W4220983882 title "Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors" @default.
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- W4220983882 doi "https://doi.org/10.1038/s41467-022-29155-1" @default.
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- W4220983882 hasPublicationYear "2022" @default.
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