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- W4220988416 abstract "Pyroptosis is an inflammatory cell death form triggered by protease-mediated truncation and release of the N-terminal pore-forming domain of the gasdermin (GSDM) family proteins in various cell types. We report a Bioorthogonally ACtivatable Base editor (BaseBAC) for in situ and on-demand initiation of cell-type-specific pyroptosis. We first made the enzymatic activity of a cytosine base editor (CBE) switchable by establishing a bioorthogonal blockage on the PAM-interacting residue to control its DNA-binding ability. The resulting BaseBAC allowed in situ control of base editing on the GSDME gene that switched to the truncated expression of its N-terminal domain to activate pyroptosis. BaseBAC offers a general method for on-demand awakening of functional domains of self-inhibiting proteins and the corresponding cellular processes with high specificity in living systems." @default.
- W4220988416 created "2022-04-03" @default.
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- W4220988416 date "2022-03-15" @default.
- W4220988416 modified "2023-10-18" @default.
- W4220988416 title "Bioorthogonally Activatable Base Editing for On-Demand Pyroptosis" @default.
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- W4220988416 doi "https://doi.org/10.1021/jacs.1c12924" @default.
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