Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220992011> ?p ?o ?g. }
- W4220992011 endingPage "43" @default.
- W4220992011 startingPage "32" @default.
- W4220992011 abstract "The characterization of new biomarkers that could help externally validate the diagnosis of COVID-19 and optimize treatments is extremely important. Many studies have established changes in immune-inflammatory and antibody levels, but few studies measured the soluble receptor for the advanced glycation end product (sRAGE), angiotensin-converting enzyme 2 (ACE2), calcium, and magnesium in COVID-19.To evaluate serum advanced glycation end-product receptor (sRAGE) and angiotensin converting enzyme (ACE)2 and peripheral oxygen saturation (SpO2) and chest CT scan abnormalities (CCTA) in COVID-19.sRAGE, ACE2, interleukin (IL)-6, IL-10, C-reactive protein (CRP), calcium, magnesium, and albumin were measured in 60 COVID-19 patients and 30 healthy controls.COVID-19 is characterized by significantly increased IL-6, CRP, IL-10, sRAGE, ACE2, and lowered SpO2, albumin, magnesium, and calcium. COVID-19 with CCTAs showed lower SpO2 and albumin. SpO2 was significantly inversely correlated with IL-6, IL-10, CRP, sRAGE, and ACE2, and positively with albumin, magnesium, and calcium. Neural networks showed that a combination of calcium, IL-6, CRP, and sRAGE yielded an accuracy of 100% in detecting COVID-19 patients, with calcium being the most important predictor followed by IL-6 and CRP. Patients with positive IgG results showed a significant elevation in the serum level of IL-6, sRAGE, and ACE2 compared to the negatively IgG patient subgroup.The results show that immune-inflammatory and RAGE pathways biomarkers may be used as an external validating criterion for the diagnosis of COVID-19. Those pathways coupled with lowered SpO2, calcium, and magnesium are drug targets that may help reduce the consequences of COVID-19." @default.
- W4220992011 created "2022-04-03" @default.
- W4220992011 creator A5002270558 @default.
- W4220992011 creator A5029230229 @default.
- W4220992011 creator A5036611681 @default.
- W4220992011 creator A5081924790 @default.
- W4220992011 date "2022-05-01" @default.
- W4220992011 modified "2023-10-16" @default.
- W4220992011 title "Increased ACE2, sRAGE, and Immune Activation, but Lowered Calcium and Magnesium in COVID-19" @default.
- W4220992011 cites W1165140024 @default.
- W4220992011 cites W1167592479 @default.
- W4220992011 cites W1995581789 @default.
- W4220992011 cites W1997259725 @default.
- W4220992011 cites W1997521253 @default.
- W4220992011 cites W2001788362 @default.
- W4220992011 cites W2002765492 @default.
- W4220992011 cites W2007473062 @default.
- W4220992011 cites W2008012867 @default.
- W4220992011 cites W2010052045 @default.
- W4220992011 cites W2023162088 @default.
- W4220992011 cites W2025939977 @default.
- W4220992011 cites W2027993632 @default.
- W4220992011 cites W2038412379 @default.
- W4220992011 cites W2039689649 @default.
- W4220992011 cites W2039765075 @default.
- W4220992011 cites W2060619742 @default.
- W4220992011 cites W2064965507 @default.
- W4220992011 cites W2067855334 @default.
- W4220992011 cites W2068227532 @default.
- W4220992011 cites W2076867308 @default.
- W4220992011 cites W2091499641 @default.
- W4220992011 cites W2093624079 @default.
- W4220992011 cites W2102634410 @default.
- W4220992011 cites W2102761280 @default.
- W4220992011 cites W2109339223 @default.
- W4220992011 cites W2110065044 @default.
- W4220992011 cites W2114081875 @default.
- W4220992011 cites W2124756338 @default.
- W4220992011 cites W2136497849 @default.
- W4220992011 cites W2150112131 @default.
- W4220992011 cites W2161528116 @default.
- W4220992011 cites W2163627712 @default.
- W4220992011 cites W2282913458 @default.
- W4220992011 cites W2310905192 @default.
- W4220992011 cites W2314816730 @default.
- W4220992011 cites W2341923562 @default.
- W4220992011 cites W2551474197 @default.
- W4220992011 cites W2596124498 @default.
- W4220992011 cites W2744355055 @default.
- W4220992011 cites W2765954649 @default.
- W4220992011 cites W2777577494 @default.
- W4220992011 cites W2783192265 @default.
- W4220992011 cites W2789996716 @default.
- W4220992011 cites W2790620629 @default.
- W4220992011 cites W2796346355 @default.
- W4220992011 cites W2836363664 @default.
- W4220992011 cites W2895009116 @default.
- W4220992011 cites W2944682402 @default.
- W4220992011 cites W2981657433 @default.
- W4220992011 cites W2996355084 @default.
- W4220992011 cites W2997384931 @default.
- W4220992011 cites W2999549161 @default.
- W4220992011 cites W3001118548 @default.
- W4220992011 cites W3001638293 @default.
- W4220992011 cites W3002108456 @default.
- W4220992011 cites W3004280078 @default.
- W4220992011 cites W3006912112 @default.
- W4220992011 cites W3007929363 @default.
- W4220992011 cites W3007940623 @default.
- W4220992011 cites W3008090866 @default.
- W4220992011 cites W3008421357 @default.
- W4220992011 cites W3008827533 @default.
- W4220992011 cites W3008985036 @default.
- W4220992011 cites W3009169728 @default.
- W4220992011 cites W3009231370 @default.
- W4220992011 cites W3009314935 @default.
- W4220992011 cites W3009335299 @default.
- W4220992011 cites W3009859788 @default.
- W4220992011 cites W3009885589 @default.
- W4220992011 cites W3009912996 @default.
- W4220992011 cites W3010025196 @default.
- W4220992011 cites W3010894410 @default.
- W4220992011 cites W3011610993 @default.
- W4220992011 cites W3012421327 @default.
- W4220992011 cites W3012422150 @default.
- W4220992011 cites W3012602168 @default.
- W4220992011 cites W3012846954 @default.
- W4220992011 cites W3012860481 @default.
- W4220992011 cites W3013385173 @default.
- W4220992011 cites W3015081226 @default.
- W4220992011 cites W3015228903 @default.
- W4220992011 cites W3015512747 @default.
- W4220992011 cites W3019269066 @default.
- W4220992011 cites W3019765297 @default.
- W4220992011 cites W3023394637 @default.
- W4220992011 cites W3024065428 @default.
- W4220992011 cites W3024541652 @default.
- W4220992011 cites W3032543466 @default.