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• W4220993208 abstract "Flagella are necessary for bacterial movement and contribute to various aspects of virulence. They are complex cylindrical structures built of multiple molecular rings with self-assembly properties. The flagellar rotor is composed of the MS-ring and the C-ring. The FliG protein of the C-ring is central to flagellar assembly and function due to its roles in linking the C-ring with the MS-ring and in torque transmission from stator to rotor. No high-resolution structure of an assembled C-ring has been resolved to date, and the conformation adopted by FliG within the ring is unclear due to variations in available crystallographic data. Here, we use molecular dynamics (MD) simulations to study the conformation and dynamics of FliG in different states of assembly, including both in physiologically relevant and crystallographic lattice environments. We conclude that the linker between the FliG N-terminal and middle domain likely adopts an extended helical conformation in vivo, in contrast with the contracted conformation observed in some previous X-ray studies. We further support our findings with integrative model building of full-length FliG and a FliG ring model that is compatible with cryo-electron tomography (cryo-ET) and electron microscopy (EM) densities of the C-ring. Collectively, our study contributes to a better mechanistic understanding of the flagellar rotor assembly and its function." @default.
• W4220993208 created "2022-04-03" @default.
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• W4220993208 date "2022-01-01" @default.
• W4220993208 modified "2023-09-25" @default.
• W4220993208 title "Bridging the N-terminal and middle domains in FliG of the flagellar rotor" @default.
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• W4220993208 doi "https://doi.org/10.1016/j.crstbi.2022.02.002" @default.
• W4220993208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35345452" @default.
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