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• W4220993307 endingPage "2275" @default.
• W4220993307 startingPage "2250" @default.
• W4220993307 abstract "Abstract Currently, enhancement of cholinergic neurotransmission via cholinesterase inhibitors represents the main available approach to treat cognitive and behavioural symptoms of the early as well as late stages of Alzheimer’s disease. Restoring the cholinergic system has been a primary means of improving cognition in Alzheimer’s disease, as four of the six approved therapies are acetylcholinesterase inhibitors. Memantine is an N-methyl-d-aspartate antagonist with a well-documented clinical effect on behavioural symptoms, which is often added to cholinesterase inhibitors to potentiate their effect and aducanumab, targeting the amyloid pathology, has recently been approved. The early, progressive and selective degeneration of the cholinergic system together and its close relation to cognitive deficits supports the use of cholinergic therapy for Alzheimer’s disease. This review provides an updated view of the basal forebrain cholinergic system, its relation to cognition and its relevance for therapy of Alzheimer’s disease. It deals with the three main aspects that form the basis of the cholinergic-oriented therapy of Alzheimer’s disease, its origin, its mechanism of action, its clinical effects, advantages and limits of a cholinergic therapeutic approach. It includes a new and updated overview of the involvement of muscarinic receptors in Alzheimer’s disease as well as the recent development of new and highly selective M1 muscarinic receptor agonists with disease-modifying potential. It also addresses the discovery of a novel nerve growth factor metabolic pathway responsible for the trophic maintenance of the basal forebrain system and its deregulation in Alzheimer’s disease. It discusses new clinical studies and provides evidence for the long-term efficacy of cholinesterase inhibitor therapy suggesting a disease-modifying effect of these drugs. The classical symptomatic cholinergic therapy based on cholinesterase inhibitors is judiciously discussed for its maximal efficacy and best clinical application. The review proposes new alternatives of cholinergic therapy that should be developed to amplify its clinical effect and supplement the disease-modifying effect of new treatments to slow down or arrest disease progression." @default.
• W4220993307 created "2022-04-03" @default.
• W4220993307 creator A5023558598 @default.
• W4220993307 creator A5064662651 @default.
• W4220993307 creator A5091736852 @default.
• W4220993307 date "2022-03-15" @default.
• W4220993307 modified "2023-10-14" @default.
• W4220993307 title "Reimagining cholinergic therapy for Alzheimer’s disease" @default.
• W4220993307 cites W109290595 @default.
• W4220993307 cites W128638448 @default.
• W4220993307 cites W1445439730 @default.
• W4220993307 cites W1490735060 @default.
• W4220993307 cites W1494330729 @default.
• W4220993307 cites W1521617494 @default.
• W4220993307 cites W1531855108 @default.
• W4220993307 cites W1553529648 @default.
• W4220993307 cites W1558672764 @default.
• W4220993307 cites W1572154908 @default.
• W4220993307 cites W1583810538 @default.
• W4220993307 cites W1596886387 @default.
• W4220993307 cites W1608424455 @default.
• W4220993307 cites W1615644378 @default.
• W4220993307 cites W1648353366 @default.
• W4220993307 cites W1696941437 @default.
• W4220993307 cites W1803418897 @default.
• W4220993307 cites W1820013501 @default.
• W4220993307 cites W1830657577 @default.
• W4220993307 cites W1848067291 @default.
• W4220993307 cites W1869587992 @default.
• W4220993307 cites W1876892944 @default.
• W4220993307 cites W189703360 @default.
• W4220993307 cites W1949622308 @default.
• W4220993307 cites W1957220992 @default.
• W4220993307 cites W1961744561 @default.
• W4220993307 cites W1965185022 @default.
• W4220993307 cites W1967518376 @default.
• W4220993307 cites W1967582720 @default.
• W4220993307 cites W1969472274 @default.
• W4220993307 cites W1971579987 @default.
• W4220993307 cites W1971834278 @default.
• W4220993307 cites W1972153963 @default.
• W4220993307 cites W1972300483 @default.
• W4220993307 cites W1973295647 @default.
• W4220993307 cites W1973929423 @default.
• W4220993307 cites W1974260579 @default.
• W4220993307 cites W1975000948 @default.
• W4220993307 cites W1975659248 @default.
• W4220993307 cites W1975862204 @default.
• W4220993307 cites W1976345323 @default.
• W4220993307 cites W1977892449 @default.
• W4220993307 cites W1978106990 @default.
• W4220993307 cites W1978749566 @default.
• W4220993307 cites W1980564728 @default.
• W4220993307 cites W1980803806 @default.
• W4220993307 cites W1980806973 @default.
• W4220993307 cites W1981710264 @default.
• W4220993307 cites W1986400971 @default.
• W4220993307 cites W1986711175 @default.
• W4220993307 cites W1987985059 @default.
• W4220993307 cites W1989309542 @default.
• W4220993307 cites W1990343815 @default.
• W4220993307 cites W1990543766 @default.
• W4220993307 cites W1992332751 @default.
• W4220993307 cites W1992511388 @default.
• W4220993307 cites W1994067502 @default.
• W4220993307 cites W1994397669 @default.
• W4220993307 cites W1995380852 @default.
• W4220993307 cites W1998761186 @default.
• W4220993307 cites W1998983311 @default.
• W4220993307 cites W1999191328 @default.
• W4220993307 cites W2002106007 @default.
• W4220993307 cites W2002496882 @default.
• W4220993307 cites W2002711073 @default.
• W4220993307 cites W2002969470 @default.
• W4220993307 cites W2004713321 @default.
• W4220993307 cites W2005609961 @default.
• W4220993307 cites W2005780620 @default.
• W4220993307 cites W2006131134 @default.
• W4220993307 cites W2006922237 @default.
• W4220993307 cites W2007272428 @default.
• W4220993307 cites W2008350281 @default.
• W4220993307 cites W2008759843 @default.
• W4220993307 cites W2009916013 @default.
• W4220993307 cites W2010120109 @default.
• W4220993307 cites W2012161540 @default.
• W4220993307 cites W2013146608 @default.
• W4220993307 cites W2014127226 @default.
• W4220993307 cites W2014256027 @default.
• W4220993307 cites W2015290739 @default.
• W4220993307 cites W2015933608 @default.
• W4220993307 cites W2016053122 @default.
• W4220993307 cites W2016061869 @default.
• W4220993307 cites W2016257709 @default.
• W4220993307 cites W2019756575 @default.
• W4220993307 cites W2020276351 @default.
• W4220993307 cites W2020350236 @default.
• W4220993307 cites W2021280501 @default.
• W4220993307 cites W2022469551 @default.

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