FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220996375> ?p ?o ?g. }

• W4220996375 abstract "Abstract Resident microbes are a feature of vertebrate animals that influence diverse aspects of their biology from tissue development to metabolism. Here we describe transcriptional responses to the microbiota across all the cells of a model developing vertebrate, the larval zebrafish. By performing single cell transcriptomic analysis of whole germ free and conventionalized larvae, we show that the impacts of the microbiota are sensed by all major organ systems but that responses are highly specific to different cell types. The presence of microbiota stimulates the expansion of progenitor-like cells in epithelial tissues and increases proliferation gene expression in progenitor-like cell populations of the immune and nervous systems. Across many cell types, including enterocytes, immune cells, and neurons, the microbiota upregulates expression of genes involved in microbial responses, cell type-specific activities, and cell type-specific deployment of ATP metabolism genes. These combined transcriptional patterns demonstrate how the microbiota simultaneously modulate cellular immune and metabolic programs. The impacts of the microbiota on tissue development are illustrated by the exocrine pancreas, which in the absence of the microbiota is smaller and composed of uniformly differentiated acinar cells. The presence of the microbiota results in exocrine pancreas enlargement and heterogeneous cellular expression of digestive enzyme and secretion genes, demonstrating how the microbiota promotes plasticity in tissue development and function. This single cell transcriptional dataset demonstrates the impacts of the microbiota on vertebrate development across the body and provides a foundation for dissecting cell type specific responses to microbial consortia members or molecules. Summary Animal development proceeds in the presence of intimate microbial associations, but the extent to which different host cells across the body respond to resident microbes remains to be fully explored. Using the vertebrate model organism, the larval zebrafish, we assessed transcriptional responses to the microbiota across the entire body at single cell resolution. We find that cell types across the body, not limited to tissues at host-microbe interfaces, respond to the microbiota. Responses are cell-type specific, but across many tissues the microbiota enhances cell proliferation, increases metabolism, and stimulates a diversity of cellular activities, revealing roles for the microbiota in promoting developmental plasticity. This work provides a resource for exploring transcriptional responses to the microbiota across all cell types of the vertebrate body and generating new hypotheses about the interactions between vertebrate hosts and their microbiota." @default.
• W4220996375 created "2022-04-03" @default.
• W4220996375 creator A5002840484 @default.
• W4220996375 creator A5007415235 @default.
• W4220996375 creator A5014539202 @default.
• W4220996375 creator A5016427014 @default.
• W4220996375 creator A5025186197 @default.
• W4220996375 creator A5040812231 @default.
• W4220996375 creator A5085665239 @default.
• W4220996375 date "2022-03-28" @default.
• W4220996375 modified "2023-09-27" @default.
• W4220996375 title "GLOBAL HOST RESPONSES TO THE MICROBIOTA AT SINGLE CELL RESOLUTION IN GNOTOBIOTIC ZEBRAFISH" @default.
• W4220996375 cites W1489080036 @default.
• W4220996375 cites W1497743187 @default.
• W4220996375 cites W1912150073 @default.
• W4220996375 cites W1964620954 @default.
• W4220996375 cites W1983320034 @default.
• W4220996375 cites W1992953684 @default.
• W4220996375 cites W1997039338 @default.
• W4220996375 cites W1999373531 @default.
• W4220996375 cites W2004854975 @default.
• W4220996375 cites W2007295851 @default.
• W4220996375 cites W2008771322 @default.
• W4220996375 cites W2031111964 @default.
• W4220996375 cites W2038569321 @default.
• W4220996375 cites W2048257108 @default.
• W4220996375 cites W2051529467 @default.
• W4220996375 cites W2059297350 @default.
• W4220996375 cites W2059543535 @default.
• W4220996375 cites W2064637565 @default.
• W4220996375 cites W2073861762 @default.
• W4220996375 cites W2078375926 @default.
• W4220996375 cites W2080532481 @default.
• W4220996375 cites W2082578477 @default.
• W4220996375 cites W2117029190 @default.
• W4220996375 cites W2123097904 @default.
• W4220996375 cites W2133645878 @default.
• W4220996375 cites W2142167067 @default.
• W4220996375 cites W2147295981 @default.
• W4220996375 cites W2152698789 @default.
• W4220996375 cites W2155424525 @default.
• W4220996375 cites W2170175976 @default.
• W4220996375 cites W2171575335 @default.
• W4220996375 cites W2195959072 @default.
• W4220996375 cites W2411170281 @default.
• W4220996375 cites W2512041706 @default.
• W4220996375 cites W2551810737 @default.
• W4220996375 cites W2580619720 @default.
• W4220996375 cites W2587680743 @default.
• W4220996375 cites W2610284646 @default.
• W4220996375 cites W2617319987 @default.
• W4220996375 cites W2752849791 @default.
• W4220996375 cites W2767024697 @default.
• W4220996375 cites W2769929740 @default.
• W4220996375 cites W2787580274 @default.
• W4220996375 cites W2791578194 @default.
• W4220996375 cites W2792163902 @default.
• W4220996375 cites W2792879701 @default.
• W4220996375 cites W2898821675 @default.
• W4220996375 cites W2899102155 @default.
• W4220996375 cites W2910387559 @default.
• W4220996375 cites W2913664791 @default.
• W4220996375 cites W2968462409 @default.
• W4220996375 cites W2969314526 @default.
• W4220996375 cites W2969958358 @default.
• W4220996375 cites W2970476735 @default.
• W4220996375 cites W2990877146 @default.
• W4220996375 cites W2991429913 @default.
• W4220996375 cites W3001807065 @default.
• W4220996375 cites W3006132083 @default.
• W4220996375 cites W3010426223 @default.
• W4220996375 cites W3015448611 @default.
• W4220996375 cites W3021685508 @default.
• W4220996375 cites W3046625324 @default.
• W4220996375 cites W3083913491 @default.
• W4220996375 cites W3092383005 @default.
• W4220996375 cites W3113213705 @default.
• W4220996375 cites W3118521001 @default.
• W4220996375 cites W3124501435 @default.
• W4220996375 cites W3134819853 @default.
• W4220996375 cites W3176544414 @default.
• W4220996375 cites W3182347382 @default.
• W4220996375 cites W3183457600 @default.
• W4220996375 cites W4225905061 @default.
• W4220996375 doi "https://doi.org/10.1101/2022.03.28.486083" @default.
• W4220996375 hasPublicationYear "2022" @default.
• W4220996375 type Work @default.
• W4220996375 citedByCount "3" @default.
• W4220996375 countsByYear W42209963752022 @default.
• W4220996375 countsByYear W42209963752023 @default.
• W4220996375 crossrefType "posted-content" @default.
• W4220996375 hasAuthorship W4220996375A5002840484 @default.
• W4220996375 hasAuthorship W4220996375A5007415235 @default.
• W4220996375 hasAuthorship W4220996375A5014539202 @default.
• W4220996375 hasAuthorship W4220996375A5016427014 @default.
• W4220996375 hasAuthorship W4220996375A5025186197 @default.
• W4220996375 hasAuthorship W4220996375A5040812231 @default.
• W4220996375 hasAuthorship W4220996375A5085665239 @default.
• W4220996375 hasBestOaLocation W42209963751 @default.
• W4220996375 hasConcept C104317684 @default.

• next