FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220996821> ?p ?o ?g. }

• W4220996821 endingPage "625" @default.
• W4220996821 startingPage "618" @default.
• W4220996821 abstract "Yttrium-90 ibritumomab tiuxetan [(90)Y-IT] is a CD20-targeted radio-immuno conjugate. Clinical trials of (90)Y-IT as a first-line stand-alone treatment in follicular lymphoma (FL) and/or marginal zone lymphoma (MZL) showed high efficacy. However, long-term survival outcomes and toxicities are not well-defined.We report a retrospective single-institution, multi-center study of (90)Y-IT in previously untreated low grade (LG)-FL and MZL at Mayo Clinic Cancer Center between January 2000 and October 2019. We selected patients with LG-FL and MZL who received standard-dose (90)Y-IT as a single agent in the first line setting.The cohort (n = 51) consists of previously untreated LG-FL (n = 41) or MZL (n = 10). Median follow-up was 5.3 years (95% CI; 4.2, 6.2). Overall response rate (ORR) was 100% with complete response rate (CR) of 94%. Continuous CR was observed in 59% patients who had more than 2 years of follow-up. Long-term CR (>7 years) was seen in 25% of patients. Median progression free survival (mPFS) for the whole cohort was not reached (NR) (95% CI; 4.9, NR). Bulky disease was associated with shorter median PFS of 3.5 years (CI 95%; 0.8, 4.9) compared to non-bulky disease NR (CI 95%; 5.8, NR), P = .02. The incidence of grade 3 or higher thrombocytopenia, neutropenia and anemia were 47%, 37%, and 4% respectively. No therapy-related myelodysplasia or acute myeloid leukemia were observed.Long real-life follow-up showed that single-agent (90)Y-IT is highly efficacious with durable long-term survival in previously untreated LG-FL and MZL without significant risk for secondary malignancies." @default.
• W4220996821 created "2022-04-03" @default.
• W4220996821 creator A5004152557 @default.
• W4220996821 creator A5009318345 @default.
• W4220996821 creator A5026397451 @default.
• W4220996821 creator A5027013288 @default.
• W4220996821 creator A5032001510 @default.
• W4220996821 creator A5066352358 @default.
• W4220996821 creator A5078705257 @default.
• W4220996821 date "2022-08-01" @default.
• W4220996821 modified "2023-10-09" @default.
• W4220996821 title "Real World Long-term Follow-up Experience with Yttrium-90 ibritumomab tiuxetan in Previously Untreated Patients with Low-Grade Follicular Lymphoma and Marginal Zone Lymphoma" @default.
• W4220996821 cites W1994244606 @default.
• W4220996821 cites W2004425015 @default.
• W4220996821 cites W2006551520 @default.
• W4220996821 cites W2038410876 @default.
• W4220996821 cites W2039021803 @default.
• W4220996821 cites W2045399297 @default.
• W4220996821 cites W2077147663 @default.
• W4220996821 cites W2080742973 @default.
• W4220996821 cites W2087830930 @default.
• W4220996821 cites W2110646221 @default.
• W4220996821 cites W2113228924 @default.
• W4220996821 cites W2116402582 @default.
• W4220996821 cites W2119147717 @default.
• W4220996821 cites W2128849659 @default.
• W4220996821 cites W2144367322 @default.
• W4220996821 cites W2146354173 @default.
• W4220996821 cites W2147581636 @default.
• W4220996821 cites W2153921055 @default.
• W4220996821 cites W2158331255 @default.
• W4220996821 cites W2164087443 @default.
• W4220996821 cites W2267583049 @default.
• W4220996821 cites W2310716991 @default.
• W4220996821 cites W2518731208 @default.
• W4220996821 cites W2611507725 @default.
• W4220996821 cites W2790380171 @default.
• W4220996821 cites W2973512921 @default.
• W4220996821 cites W3011485479 @default.
• W4220996821 cites W3047410973 @default.
• W4220996821 cites W4210961312 @default.
• W4220996821 cites W4243297328 @default.
• W4220996821 doi "https://doi.org/10.1016/j.clml.2022.03.004" @default.
• W4220996821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35400611" @default.
• W4220996821 hasPublicationYear "2022" @default.
• W4220996821 type Work @default.
• W4220996821 citedByCount "2" @default.
• W4220996821 countsByYear W42209968212023 @default.
• W4220996821 crossrefType "journal-article" @default.
• W4220996821 hasAuthorship W4220996821A5004152557 @default.
• W4220996821 hasAuthorship W4220996821A5009318345 @default.
• W4220996821 hasAuthorship W4220996821A5026397451 @default.
• W4220996821 hasAuthorship W4220996821A5027013288 @default.
• W4220996821 hasAuthorship W4220996821A5032001510 @default.
• W4220996821 hasAuthorship W4220996821A5066352358 @default.
• W4220996821 hasAuthorship W4220996821A5078705257 @default.
• W4220996821 hasBestOaLocation W42209968211 @default.
• W4220996821 hasConcept C126322002 @default.
• W4220996821 hasConcept C141071460 @default.
• W4220996821 hasConcept C159654299 @default.
• W4220996821 hasConcept C203014093 @default.
• W4220996821 hasConcept C2776146153 @default.
• W4220996821 hasConcept C2776694085 @default.
• W4220996821 hasConcept C2777058707 @default.
• W4220996821 hasConcept C2777063308 @default.
• W4220996821 hasConcept C2778515704 @default.
• W4220996821 hasConcept C2779338263 @default.
• W4220996821 hasConcept C2780653079 @default.
• W4220996821 hasConcept C542903549 @default.
• W4220996821 hasConcept C71924100 @default.
• W4220996821 hasConcept C72563966 @default.
• W4220996821 hasConcept C90924648 @default.
• W4220996821 hasConceptScore W4220996821C126322002 @default.
• W4220996821 hasConceptScore W4220996821C141071460 @default.
• W4220996821 hasConceptScore W4220996821C159654299 @default.
• W4220996821 hasConceptScore W4220996821C203014093 @default.
• W4220996821 hasConceptScore W4220996821C2776146153 @default.
• W4220996821 hasConceptScore W4220996821C2776694085 @default.
• W4220996821 hasConceptScore W4220996821C2777058707 @default.
• W4220996821 hasConceptScore W4220996821C2777063308 @default.
• W4220996821 hasConceptScore W4220996821C2778515704 @default.
• W4220996821 hasConceptScore W4220996821C2779338263 @default.
• W4220996821 hasConceptScore W4220996821C2780653079 @default.
• W4220996821 hasConceptScore W4220996821C542903549 @default.
• W4220996821 hasConceptScore W4220996821C71924100 @default.
• W4220996821 hasConceptScore W4220996821C72563966 @default.
• W4220996821 hasConceptScore W4220996821C90924648 @default.
• W4220996821 hasIssue "8" @default.
• W4220996821 hasLocation W42209968211 @default.
• W4220996821 hasLocation W42209968212 @default.
• W4220996821 hasOpenAccess W4220996821 @default.
• W4220996821 hasPrimaryLocation W42209968211 @default.
• W4220996821 hasRelatedWork W1995300466 @default.
• W4220996821 hasRelatedWork W2005708883 @default.
• W4220996821 hasRelatedWork W2038804865 @default.
• W4220996821 hasRelatedWork W2053328285 @default.
• W4220996821 hasRelatedWork W2074506590 @default.
• W4220996821 hasRelatedWork W2107990794 @default.

• next