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• W4220997164 abstract "In eukaryotes, N6 -methyladenosine (m6 A) is abundant on mRNA, and plays key roles in the regulation of RNA function. However, the roles and regulatory mechanisms of m6 A in phytopathogenic fungi are still largely unknown. Combined with biochemical analysis, MeRIP-seq and RNA-seq methods, as well as biological analysis, we showed that Magnaporthe oryzae MTA1 gene is an orthologue of human METTL4, which is involved in m6 A modification and plays a critical role in autophagy for fungal infection. The Δmta1 mutant showed reduced virulence due to blockage of appressorial penetration and invasive growth. Moreover, the autophagy process was severely disordered in the mutant. MeRIP-seq identified 659 hypomethylated m6 A peaks covering 595 mRNAs in Δmta1 appressoria, 114 m6 A peaks was negatively related to mRNA abundance, including several ATG gene transcripts. Typically, the mRNA abundance of MoATG8 was also increased in the single m6 A site mutant ∆atg8/MoATG8A982C , leading to an autophagy disorder. Our findings reveal the functional importance of the m6 A methylation in infection of M. oryzae and provide novel insight into the regulatory mechanisms of plant pathogenic fungi." @default.
• W4220997164 created "2022-04-03" @default.
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• W4220997164 date "2022-04-13" @default.
• W4220997164 modified "2023-10-12" @default.
• W4220997164 title "MTA1‐mediated RNA m⁶A modification regulates autophagy and is required for infection of the rice blast fungus" @default.
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• W4220997164 cites W1970460195 @default.
• W4220997164 cites W1974702375 @default.
• W4220997164 cites W1979611479 @default.
• W4220997164 cites W1981629946 @default.
• W4220997164 cites W1984774548 @default.
• W4220997164 cites W1991807334 @default.
• W4220997164 cites W2002458471 @default.
• W4220997164 cites W2007429249 @default.
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• W4220997164 cites W2466739815 @default.
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• W4220997164 cites W2616848081 @default.
• W4220997164 cites W2729819424 @default.
• W4220997164 cites W2732795955 @default.
• W4220997164 cites W2753775066 @default.
• W4220997164 cites W2758797028 @default.
• W4220997164 cites W2761676504 @default.
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• W4220997164 doi "https://doi.org/10.1111/nph.18117" @default.
• W4220997164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35338654" @default.
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