FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220997610> ?p ?o ?g. }

• W4220997610 endingPage "173" @default.
• W4220997610 startingPage "163" @default.
• W4220997610 abstract "Moxifloxacin is a fluoroquinolone that is commonly used in adults, but not children. Certain clinical situations compel pediatric clinicians to use moxifloxacin, despite its potential for toxicity and limited pharmacokinetics (PK) data. Our objective was to further characterize the pharmacokinetics of moxifloxacin in children.We performed an opportunistic, open-label population PK study of moxifloxacin in children < 18 years of age who received moxifloxacin as part of standard care. A set of structural PK models and residual error models were explored using nonlinear mixed-effects modeling. Covariates with known biological relationships were investigated for their influence on PK parameters.We obtained 43 moxifloxacin concentrations from 14 participants who received moxifloxacin intravenously (n = 8) or orally (n = 6). The dose of moxifloxacin was 10 mg/kg daily in participants ≤ 40 kg and 400 mg daily in participants > 40 kg. The population mean clearance and mean volume of distribution were 18.2 L/h and 167 L, respectively. The oral absorption was described by a first-order process. The estimated extent of oral bioavailability was highly variable (range 20-91%). Total body weight was identified as a covariate on clearance and volume of distribution, and substantially reduced the random unexplained inter-individual variability for both parameters. No participants experienced suspected serious adverse reactions related to moxifloxacin.These data add to the existing literature to support use of moxifloxacin in children in certain situations; however, further prospective studies on the safety and efficacy of moxifloxacin are needed." @default.
• W4220997610 created "2022-04-03" @default.
• W4220997610 creator A5005747264 @default.
• W4220997610 creator A5030691636 @default.
• W4220997610 creator A5033177226 @default.
• W4220997610 creator A5037393232 @default.
• W4220997610 creator A5040455092 @default.
• W4220997610 creator A5041616368 @default.
• W4220997610 creator A5042046351 @default.
• W4220997610 creator A5064978319 @default.
• W4220997610 creator A5067325373 @default.
• W4220997610 creator A5067695269 @default.
• W4220997610 creator A5081696273 @default.
• W4220997610 date "2022-03-01" @default.
• W4220997610 modified "2023-09-26" @default.
• W4220997610 title "Population Pharmacokinetics of Moxifloxacin in Children" @default.
• W4220997610 cites W1698511513 @default.
• W4220997610 cites W1975774707 @default.
• W4220997610 cites W1982428643 @default.
• W4220997610 cites W1994823611 @default.
• W4220997610 cites W1997435036 @default.
• W4220997610 cites W2009119563 @default.
• W4220997610 cites W2013434417 @default.
• W4220997610 cites W2100542978 @default.
• W4220997610 cites W2108466686 @default.
• W4220997610 cites W2114905669 @default.
• W4220997610 cites W2123465883 @default.
• W4220997610 cites W2128986803 @default.
• W4220997610 cites W2129081916 @default.
• W4220997610 cites W2131257192 @default.
• W4220997610 cites W2150760368 @default.
• W4220997610 cites W2151486491 @default.
• W4220997610 cites W2152930906 @default.
• W4220997610 cites W2169788739 @default.
• W4220997610 cites W2171039948 @default.
• W4220997610 cites W2470864752 @default.
• W4220997610 cites W2766182385 @default.
• W4220997610 cites W2887939111 @default.
• W4220997610 cites W2912528317 @default.
• W4220997610 cites W2961063228 @default.
• W4220997610 cites W2968045241 @default.
• W4220997610 cites W82875543 @default.
• W4220997610 doi "https://doi.org/10.1007/s40272-022-00493-3" @default.
• W4220997610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35284983" @default.
• W4220997610 hasPublicationYear "2022" @default.
• W4220997610 type Work @default.
• W4220997610 citedByCount "1" @default.
• W4220997610 countsByYear W42209976102023 @default.
• W4220997610 crossrefType "journal-article" @default.
• W4220997610 hasAuthorship W4220997610A5005747264 @default.
• W4220997610 hasAuthorship W4220997610A5030691636 @default.
• W4220997610 hasAuthorship W4220997610A5033177226 @default.
• W4220997610 hasAuthorship W4220997610A5037393232 @default.
• W4220997610 hasAuthorship W4220997610A5040455092 @default.
• W4220997610 hasAuthorship W4220997610A5041616368 @default.
• W4220997610 hasAuthorship W4220997610A5042046351 @default.
• W4220997610 hasAuthorship W4220997610A5064978319 @default.
• W4220997610 hasAuthorship W4220997610A5067325373 @default.
• W4220997610 hasAuthorship W4220997610A5067695269 @default.
• W4220997610 hasAuthorship W4220997610A5081696273 @default.
• W4220997610 hasBestOaLocation W42209976102 @default.
• W4220997610 hasConcept C112705442 @default.
• W4220997610 hasConcept C126322002 @default.
• W4220997610 hasConcept C139254425 @default.
• W4220997610 hasConcept C181389837 @default.
• W4220997610 hasConcept C197934379 @default.
• W4220997610 hasConcept C2778836808 @default.
• W4220997610 hasConcept C2908647359 @default.
• W4220997610 hasConcept C501593827 @default.
• W4220997610 hasConcept C71924100 @default.
• W4220997610 hasConcept C86803240 @default.
• W4220997610 hasConcept C89423630 @default.
• W4220997610 hasConcept C98274493 @default.
• W4220997610 hasConcept C99454951 @default.
• W4220997610 hasConceptScore W4220997610C112705442 @default.
• W4220997610 hasConceptScore W4220997610C126322002 @default.
• W4220997610 hasConceptScore W4220997610C139254425 @default.
• W4220997610 hasConceptScore W4220997610C181389837 @default.
• W4220997610 hasConceptScore W4220997610C197934379 @default.
• W4220997610 hasConceptScore W4220997610C2778836808 @default.
• W4220997610 hasConceptScore W4220997610C2908647359 @default.
• W4220997610 hasConceptScore W4220997610C501593827 @default.
• W4220997610 hasConceptScore W4220997610C71924100 @default.
• W4220997610 hasConceptScore W4220997610C86803240 @default.
• W4220997610 hasConceptScore W4220997610C89423630 @default.
• W4220997610 hasConceptScore W4220997610C98274493 @default.
• W4220997610 hasConceptScore W4220997610C99454951 @default.
• W4220997610 hasIssue "2" @default.
• W4220997610 hasLocation W42209976101 @default.
• W4220997610 hasLocation W42209976102 @default.
• W4220997610 hasLocation W42209976103 @default.
• W4220997610 hasOpenAccess W4220997610 @default.
• W4220997610 hasPrimaryLocation W42209976101 @default.
• W4220997610 hasRelatedWork W1897820813 @default.
• W4220997610 hasRelatedWork W1976294365 @default.
• W4220997610 hasRelatedWork W1996305828 @default.
• W4220997610 hasRelatedWork W2020343058 @default.
• W4220997610 hasRelatedWork W2022442895 @default.

• next