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• W4220997919 abstract "Developing organs are shaped, in part, by physical interaction with their environment in the embryo. In recent years, technical advances in live-cell imaging and material science have greatly expanded our understanding of the mechanical forces driving organ formation. Here, we provide a broad overview of the types of forces generated during embryonic development and then focus on a subset of organs underlying our senses: the eyes, inner ears, nose and skin. The epithelia in these organs emerge from a common origin: the ectoderm germ layer; yet, they arrive at unique and complex forms over developmental time. We discuss exciting recent animal studies that show a crucial role for mechanical forces in, for example, the thickening of sensory placodes, the coiling of the cochlea and the lengthening of hair. Finally, we discuss how microfabricated organoid systems can now provide unprecedented insights into the physical principles of human development." @default.
• W4220997919 created "2022-04-03" @default.
• W4220997919 creator A5038890216 @default.
• W4220997919 creator A5056854890 @default.
• W4220997919 creator A5086772228 @default.
• W4220997919 date "2022-03-31" @default.
• W4220997919 modified "2023-09-25" @default.
• W4220997919 title "The mechanical forces that shape our senses" @default.
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