Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220999710> ?p ?o ?g. }
- W4220999710 endingPage "7" @default.
- W4220999710 startingPage "1" @default.
- W4220999710 abstract "The purpose of this study was to demonstrate the pharmacodynamic material basis and molecular mechanism of pilose antler (PA) in the prevention and treatment of osteoporosis (OP) by the method of network pharmacology.First, the active components of PA were screened by BATMAN-TCM database, and the component targets were obtained from the SwissTargetPrediction online tool. Moreover, the relevant target genes of OP were obtained by searching the DisGeNET database. Second, the Venn diagram was drawn to obtain the PA-OP common targets, and the protein-protein interaction (PPI) network and drug-component-target (D-C-T) network were constructed by Cytoscape software. Finally, the GO functional annotation and KEGG pathway enrichment analysis of common targets were performed using the Metascape online tool.82 common targets were identified by generating a Venn diagram. The PPI network of 82 common targets indicated that the top 5 nodal targets, including PIK3CA, MAPK1, ESR1, AKT1, and SRC, were strongly associated with other proteins. The D-C-T network suggested that the active components with high degree of connectivity include Prostaglandin E1, 17-Beta-Estradiol, Alpha-Estradiol, and Estrone. Furthermore, the GO enrichment analysis revealed that the biological process categories were dominated by response to peptide, cellular response to lipid, regulation of MAPK cascade, and so on. Additionally, the KEGG pathway analysis indicated the estrogen signaling pathway, osteoclast differentiation, and HIF-1 signaling pathway might have critical effects on the development of OP.The study shows that PA has the characteristics of multi-component, multi-target, and multi-pathway in treating osteoporosis." @default.
- W4220999710 created "2022-04-03" @default.
- W4220999710 creator A5011373660 @default.
- W4220999710 creator A5030580429 @default.
- W4220999710 creator A5036248455 @default.
- W4220999710 creator A5046229353 @default.
- W4220999710 creator A5073163893 @default.
- W4220999710 creator A5086793487 @default.
- W4220999710 date "2022-03-30" @default.
- W4220999710 modified "2023-10-14" @default.
- W4220999710 title "Mechanism of Pilose Antler in Treatment of Osteoporosis Based on Network Pharmacology" @default.
- W4220999710 cites W1968315641 @default.
- W4220999710 cites W2000825328 @default.
- W4220999710 cites W2009608221 @default.
- W4220999710 cites W2025472901 @default.
- W4220999710 cites W2033915160 @default.
- W4220999710 cites W2070370334 @default.
- W4220999710 cites W207693304 @default.
- W4220999710 cites W2086055862 @default.
- W4220999710 cites W2106391842 @default.
- W4220999710 cites W2115513246 @default.
- W4220999710 cites W2119221073 @default.
- W4220999710 cites W2153461492 @default.
- W4220999710 cites W2159675211 @default.
- W4220999710 cites W2168938595 @default.
- W4220999710 cites W2177317049 @default.
- W4220999710 cites W2279201083 @default.
- W4220999710 cites W2537679995 @default.
- W4220999710 cites W2559715227 @default.
- W4220999710 cites W2564414342 @default.
- W4220999710 cites W2588828272 @default.
- W4220999710 cites W2593176072 @default.
- W4220999710 cites W2737572236 @default.
- W4220999710 cites W2765141896 @default.
- W4220999710 cites W2908235934 @default.
- W4220999710 cites W2914677939 @default.
- W4220999710 cites W2928665623 @default.
- W4220999710 cites W2952784005 @default.
- W4220999710 cites W2961883274 @default.
- W4220999710 cites W2969537119 @default.
- W4220999710 cites W2969858506 @default.
- W4220999710 cites W2987227353 @default.
- W4220999710 cites W2990451375 @default.
- W4220999710 cites W2991926316 @default.
- W4220999710 cites W3043897231 @default.
- W4220999710 cites W3049196380 @default.
- W4220999710 cites W3093400792 @default.
- W4220999710 cites W3100758101 @default.
- W4220999710 cites W3113439405 @default.
- W4220999710 cites W3165301336 @default.
- W4220999710 cites W3209993550 @default.
- W4220999710 cites W4211221406 @default.
- W4220999710 cites W4237095724 @default.
- W4220999710 doi "https://doi.org/10.1155/2022/5298892" @default.
- W4220999710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35399830" @default.
- W4220999710 hasPublicationYear "2022" @default.
- W4220999710 type Work @default.
- W4220999710 citedByCount "1" @default.
- W4220999710 countsByYear W42209997102023 @default.
- W4220999710 crossrefType "journal-article" @default.
- W4220999710 hasAuthorship W4220999710A5011373660 @default.
- W4220999710 hasAuthorship W4220999710A5030580429 @default.
- W4220999710 hasAuthorship W4220999710A5036248455 @default.
- W4220999710 hasAuthorship W4220999710A5046229353 @default.
- W4220999710 hasAuthorship W4220999710A5073163893 @default.
- W4220999710 hasAuthorship W4220999710A5086793487 @default.
- W4220999710 hasBestOaLocation W42209997101 @default.
- W4220999710 hasConcept C104317684 @default.
- W4220999710 hasConcept C111472728 @default.
- W4220999710 hasConcept C121608353 @default.
- W4220999710 hasConcept C138885662 @default.
- W4220999710 hasConcept C145420912 @default.
- W4220999710 hasConcept C150194340 @default.
- W4220999710 hasConcept C152724338 @default.
- W4220999710 hasConcept C15744967 @default.
- W4220999710 hasConcept C172313692 @default.
- W4220999710 hasConcept C2987395477 @default.
- W4220999710 hasConcept C530470458 @default.
- W4220999710 hasConcept C54355233 @default.
- W4220999710 hasConcept C55105296 @default.
- W4220999710 hasConcept C55508974 @default.
- W4220999710 hasConcept C60644358 @default.
- W4220999710 hasConcept C70721500 @default.
- W4220999710 hasConcept C84606932 @default.
- W4220999710 hasConcept C86803240 @default.
- W4220999710 hasConcept C89611455 @default.
- W4220999710 hasConceptScore W4220999710C104317684 @default.
- W4220999710 hasConceptScore W4220999710C111472728 @default.
- W4220999710 hasConceptScore W4220999710C121608353 @default.
- W4220999710 hasConceptScore W4220999710C138885662 @default.
- W4220999710 hasConceptScore W4220999710C145420912 @default.
- W4220999710 hasConceptScore W4220999710C150194340 @default.
- W4220999710 hasConceptScore W4220999710C152724338 @default.
- W4220999710 hasConceptScore W4220999710C15744967 @default.
- W4220999710 hasConceptScore W4220999710C172313692 @default.
- W4220999710 hasConceptScore W4220999710C2987395477 @default.
- W4220999710 hasConceptScore W4220999710C530470458 @default.
- W4220999710 hasConceptScore W4220999710C54355233 @default.