FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220999737> ?p ?o ?g. }

• W4220999737 endingPage "1492" @default.
• W4220999737 startingPage "1492" @default.
• W4220999737 abstract "Introduction: Most patients with urothelial carcinoma are diagnosed with non-invasive tumors, but the prognosis worsens with the progression of the disease. Overexpression of cyclin-dependent kinase 9 has been recently linked to increased cancer proliferation, faster progression, and worse prognosis. However, some cancers seem to contradict this rule. In this work, we explored the prognostic role of CDK9 expression in urothelial carcinoma. Materials and Methods: We performed immunohistochemical analysis on 72 bladder cancer samples. To assess a larger group of patients, the Cancer Genome Atlas (TCGA) database containing 406 cases and transcriptomics information through the Human Pathology Atlas were analyzed. Results: CDK9 is overexpressed in urothelial cancer tissues when compared to normal urothelial tissues (p < 0.05). High CDK9 expression was observed in low-stage, low-grade, and non-muscle-invasive tumors (p < 0.05). The patients with high CDK9 expression had a significantly higher 5-year overall survival rate than those with low CDK9 expression (77.54% vs. 53.6% in the TMA group and 57.75% vs. 35.44% in the TCGA group, respectively) (p < 0.05). The results were consistent in both cohorts. Multivariate Cox regression analysis indicated that low CDK9 status was an independent predictor for poor prognosis in the TCGA cohort (HR 1.60, CL95% 1.1−2.33, p = 0.014). Conclusions: High CDK9 expression predicts a favorable prognosis in urothelial carcinoma and is associated with clinicopathological features characteristic for early-stage disease. The decrease in CDK9 expression can be associated with the build-up of genetic instability and may indicate a key role for CDK9 in the early stages of urothelial carcinoma." @default.
• W4220999737 created "2022-04-03" @default.
• W4220999737 creator A5008803496 @default.
• W4220999737 creator A5014041258 @default.
• W4220999737 creator A5032018476 @default.
• W4220999737 creator A5050760574 @default.
• W4220999737 creator A5055740943 @default.
• W4220999737 creator A5055975070 @default.
• W4220999737 creator A5057531899 @default.
• W4220999737 creator A5070840025 @default.
• W4220999737 creator A5072489285 @default.
• W4220999737 creator A5083835741 @default.
• W4220999737 creator A5090230814 @default.
• W4220999737 date "2022-03-15" @default.
• W4220999737 modified "2023-09-25" @default.
• W4220999737 title "The Prognostic Role of CDK9 in Bladder Cancer" @default.
• W4220999737 cites W1535259433 @default.
• W4220999737 cites W1970128497 @default.
• W4220999737 cites W1970462751 @default.
• W4220999737 cites W1972674519 @default.
• W4220999737 cites W1972890601 @default.
• W4220999737 cites W1984372257 @default.
• W4220999737 cites W1988133520 @default.
• W4220999737 cites W1997216192 @default.
• W4220999737 cites W1998734250 @default.
• W4220999737 cites W2008183573 @default.
• W4220999737 cites W2010119958 @default.
• W4220999737 cites W2019179533 @default.
• W4220999737 cites W2029829614 @default.
• W4220999737 cites W2035300822 @default.
• W4220999737 cites W2035563427 @default.
• W4220999737 cites W2038192505 @default.
• W4220999737 cites W2061125415 @default.
• W4220999737 cites W2088771571 @default.
• W4220999737 cites W2090429906 @default.
• W4220999737 cites W2095057691 @default.
• W4220999737 cites W2096477951 @default.
• W4220999737 cites W2118475358 @default.
• W4220999737 cites W2148024463 @default.
• W4220999737 cites W2153349010 @default.
• W4220999737 cites W2172559727 @default.
• W4220999737 cites W2291659253 @default.
• W4220999737 cites W2303609953 @default.
• W4220999737 cites W2312283262 @default.
• W4220999737 cites W2318318177 @default.
• W4220999737 cites W2589815784 @default.
• W4220999737 cites W2738102269 @default.
• W4220999737 cites W2751055844 @default.
• W4220999737 cites W2789081184 @default.
• W4220999737 cites W2892569486 @default.
• W4220999737 cites W2897550157 @default.
• W4220999737 cites W2900810351 @default.
• W4220999737 cites W2905937313 @default.
• W4220999737 cites W2913657001 @default.
• W4220999737 cites W2947811446 @default.
• W4220999737 cites W2996220288 @default.
• W4220999737 cites W2996687458 @default.
• W4220999737 cites W3006035456 @default.
• W4220999737 cites W3011714452 @default.
• W4220999737 cites W3023457002 @default.
• W4220999737 cites W3036941872 @default.
• W4220999737 cites W3048201207 @default.
• W4220999737 cites W3087090177 @default.
• W4220999737 cites W3157114139 @default.
• W4220999737 cites W3162070568 @default.
• W4220999737 cites W3162631736 @default.
• W4220999737 cites W3174714746 @default.
• W4220999737 cites W3175562628 @default.
• W4220999737 doi "https://doi.org/10.3390/cancers14061492" @default.
• W4220999737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35326643" @default.
• W4220999737 hasPublicationYear "2022" @default.
• W4220999737 type Work @default.
• W4220999737 citedByCount "6" @default.
• W4220999737 countsByYear W42209997372022 @default.
• W4220999737 countsByYear W42209997372023 @default.
• W4220999737 crossrefType "journal-article" @default.
• W4220999737 hasAuthorship W4220999737A5008803496 @default.
• W4220999737 hasAuthorship W4220999737A5014041258 @default.
• W4220999737 hasAuthorship W4220999737A5032018476 @default.
• W4220999737 hasAuthorship W4220999737A5050760574 @default.
• W4220999737 hasAuthorship W4220999737A5055740943 @default.
• W4220999737 hasAuthorship W4220999737A5055975070 @default.
• W4220999737 hasAuthorship W4220999737A5057531899 @default.
• W4220999737 hasAuthorship W4220999737A5070840025 @default.
• W4220999737 hasAuthorship W4220999737A5072489285 @default.
• W4220999737 hasAuthorship W4220999737A5083835741 @default.
• W4220999737 hasAuthorship W4220999737A5090230814 @default.
• W4220999737 hasBestOaLocation W42209997371 @default.
• W4220999737 hasConcept C121608353 @default.
• W4220999737 hasConcept C126322002 @default.
• W4220999737 hasConcept C143998085 @default.
• W4220999737 hasConcept C146357865 @default.
• W4220999737 hasConcept C151730666 @default.
• W4220999737 hasConcept C204232928 @default.
• W4220999737 hasConcept C2780352672 @default.
• W4220999737 hasConcept C502942594 @default.
• W4220999737 hasConcept C50382708 @default.
• W4220999737 hasConcept C71924100 @default.

• next