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- W4221001285 abstract "Purpose: Investigate the effect of polymicrobial interactions on antimicrobial resistance (AMR) of ocular pathogens in polymicrobial settings, compared with monomicrobial infections. Methods: Polymicrobial interactions were labeled as antagonistic, synergistic or indifferent based on a reduction, an increase or no change, respectively, in antibiotics' MIC by the Vitek 2 compact system, compared with monomicrobial pathogens. Results:Staphylococcus epidermidis showed antagonistic polymicrobial interactions (22.6%); Pseudomonas aeruginosa showed synergistic interactions (62.5%); multidrug-resistant Acinetobacter baumannii showed increased susceptibility to select antibiotics; Serratia ficaria (inherently colistin resistant) became colistin-susceptible in polymicrobial combinations. Conclusion: Both antagonistic and synergistic interactions exist among human pathogens in polymicrobial settings. Gram-positive pathogens had significantly higher antagonistic polymicrobial interactions (increased MICs: 20.4%) compared with Gram-negative ones (synergistic: 59.4%)." @default.
- W4221001285 created "2022-04-03" @default.
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- W4221001285 date "2022-05-01" @default.
- W4221001285 modified "2023-09-27" @default.
- W4221001285 title "Effect of polymicrobial interactions on antimicrobial resistance: an <i>in vitro</i> analysis in human ocular infections" @default.
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- W4221001285 doi "https://doi.org/10.2217/fmb-2021-0114" @default.
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