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- W4221001419 abstract "Abstract Purpose This study sought to investigate the protective effect of 2-mercaptoethane sodium sulfonate (mesna) on the ovarian reserve of rats being treated with cyclophosphamide. Methods Twenty-four adult female Wistar albino rats were equally divided into three groups. Group A (n = 8) received saline injections, Group B (n = 8) received cyclophosphamide, and Group C (n = 8) received cyclophosphamide + mesna. Preoperative blood samples (1 ml) were taken from all of the rats prior to any medication being given. The rats in all of the groups underwent bilateral oophorectomy and 1 ml of blood samples were taken 24 hours after the surgery. The difference in the anti-Müllerian hormone (AMH) level between the pre- and postoperative blood samples was determined. The rats’ ovaries were histomorphologically evaluated. Immune staining was performed to detect the AMH receptor expression level in the ovarian tissue. Finally, a terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) analysis was performed to assess the level of apoptosis. Results A considerable increase was noted in the AMH receptor expression level in Group C when compared with Group B (122 vs. 117, respectively; p: 0.007). In addition, the number of atretic follicles was found to be significantly lower in Group C than in Group B (10 vs. 5 respectively; p: 0.002). However, the TUNEL analysis revealed no significant difference between Group B and Group C with regard to apoptosis. Conclusion Mesna could decrease follicular atresia and increase the expression of AMH receptors in the follicles following acute cyclophosphamide toxicity." @default.
- W4221001419 created "2022-04-03" @default.
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- W4221001419 date "2022-03-15" @default.
- W4221001419 modified "2023-10-14" @default.
- W4221001419 title "Does mesna (mercapto-ethanesulphonate sodium) protect ovarian reserve after cyclophosphamide treatment: an in vivo study with rats" @default.
- W4221001419 doi "https://doi.org/10.21203/rs.3.rs-1399403/v1" @default.
- W4221001419 hasPublicationYear "2022" @default.
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