Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221001705> ?p ?o ?g. }
- W4221001705 endingPage "101799" @default.
- W4221001705 startingPage "101799" @default.
- W4221001705 abstract "Escherichia coli is one of the major pathogens causing mastitis that adversely affects the dairy industry worldwide. This study employed whole genome sequence (WGS) approach to characterize the repertoire of antibiotic resistance genes (resistome), virulence genes (virulome), phylogenetic relationship and genome wide comparison of a multi drug resistant (MDR) E. coli(SCM-21) isolated from a case of subclinical bovine mastitis in Bangalore, India. The genome of E. coli SCM- 21 was found to be of 4.29 Mb size with 50.6% GC content, comprising a resistome of 22 genes encoding beta-lactamases (blaTEM,blaAmpC), polymyxin resistance (arnA) and various efflux pumps (acr, ade, emr,rob, mac, mar, rob), attributing to the bacteria's overall antibiotic resistance genetic profile. The virulome of E. coli SCM-21 consisted of genes encoding different traits [adhesion (ecp, fim, fde), biofilm formation (csg) and toxin production (ent, esp, fep, gsp)], necessary for manifestation of the infection. Phylogenetic relationship of E. coli SCM- 21 with other global E. coli strains (n = 4867) revealed its close genetic relatedness with E. coli strains originating from different hosts of varied geographical regions [human (Germany) bos taurus (USA, Belgium and Scotland) and chicken (China)]. Further, genome wide comparative analysis with E. coli (n = 6) from human and other animal origins showed synteny across the genomes. Overall findings of this study provided a comprehensive insight of the hidden genetic determinants/power of E. coli SCM-21 that might be responsible for manifestation of mastitis and failure of antibiotic treatment. Aforesaid strain forms a reservoir of antibiotic resistance genes (ARGs) and can integrate to one health micro biosphere." @default.
- W4221001705 created "2022-04-03" @default.
- W4221001705 creator A5015204331 @default.
- W4221001705 creator A5022355086 @default.
- W4221001705 creator A5033360347 @default.
- W4221001705 creator A5044849339 @default.
- W4221001705 creator A5070753767 @default.
- W4221001705 date "2022-06-01" @default.
- W4221001705 modified "2023-10-04" @default.
- W4221001705 title "Genetic characterization and comparative genomics of a multi drug resistant (MDR) Escherichia coli SCM-21 isolated from a subclinical case of bovine mastitis" @default.
- W4221001705 cites W1540044121 @default.
- W4221001705 cites W1608896783 @default.
- W4221001705 cites W1747736870 @default.
- W4221001705 cites W1964205028 @default.
- W4221001705 cites W1966597734 @default.
- W4221001705 cites W1978333365 @default.
- W4221001705 cites W1985106082 @default.
- W4221001705 cites W1987846907 @default.
- W4221001705 cites W1991330646 @default.
- W4221001705 cites W1991810682 @default.
- W4221001705 cites W2099303284 @default.
- W4221001705 cites W2099534959 @default.
- W4221001705 cites W2117043113 @default.
- W4221001705 cites W2119497560 @default.
- W4221001705 cites W2125778198 @default.
- W4221001705 cites W2134852597 @default.
- W4221001705 cites W2162802558 @default.
- W4221001705 cites W2164739851 @default.
- W4221001705 cites W2165548028 @default.
- W4221001705 cites W2253334047 @default.
- W4221001705 cites W2258801341 @default.
- W4221001705 cites W232900828 @default.
- W4221001705 cites W2478011462 @default.
- W4221001705 cites W2523590463 @default.
- W4221001705 cites W2557304321 @default.
- W4221001705 cites W2593928562 @default.
- W4221001705 cites W2754227850 @default.
- W4221001705 cites W2899573152 @default.
- W4221001705 cites W2909466667 @default.
- W4221001705 cites W2910318409 @default.
- W4221001705 cites W3030817433 @default.
- W4221001705 cites W3049347389 @default.
- W4221001705 cites W3084390023 @default.
- W4221001705 cites W3187949311 @default.
- W4221001705 doi "https://doi.org/10.1016/j.cimid.2022.101799" @default.
- W4221001705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35397469" @default.
- W4221001705 hasPublicationYear "2022" @default.
- W4221001705 type Work @default.
- W4221001705 citedByCount "2" @default.
- W4221001705 countsByYear W42210017052023 @default.
- W4221001705 crossrefType "journal-article" @default.
- W4221001705 hasAuthorship W4221001705A5015204331 @default.
- W4221001705 hasAuthorship W4221001705A5022355086 @default.
- W4221001705 hasAuthorship W4221001705A5033360347 @default.
- W4221001705 hasAuthorship W4221001705A5044849339 @default.
- W4221001705 hasAuthorship W4221001705A5070753767 @default.
- W4221001705 hasConcept C104317684 @default.
- W4221001705 hasConcept C105176652 @default.
- W4221001705 hasConcept C141231307 @default.
- W4221001705 hasConcept C189206191 @default.
- W4221001705 hasConcept C2776650774 @default.
- W4221001705 hasConcept C2776666601 @default.
- W4221001705 hasConcept C501593827 @default.
- W4221001705 hasConcept C54355233 @default.
- W4221001705 hasConcept C547475151 @default.
- W4221001705 hasConcept C60987743 @default.
- W4221001705 hasConcept C86803240 @default.
- W4221001705 hasConcept C89423630 @default.
- W4221001705 hasConcept C94665300 @default.
- W4221001705 hasConceptScore W4221001705C104317684 @default.
- W4221001705 hasConceptScore W4221001705C105176652 @default.
- W4221001705 hasConceptScore W4221001705C141231307 @default.
- W4221001705 hasConceptScore W4221001705C189206191 @default.
- W4221001705 hasConceptScore W4221001705C2776650774 @default.
- W4221001705 hasConceptScore W4221001705C2776666601 @default.
- W4221001705 hasConceptScore W4221001705C501593827 @default.
- W4221001705 hasConceptScore W4221001705C54355233 @default.
- W4221001705 hasConceptScore W4221001705C547475151 @default.
- W4221001705 hasConceptScore W4221001705C60987743 @default.
- W4221001705 hasConceptScore W4221001705C86803240 @default.
- W4221001705 hasConceptScore W4221001705C89423630 @default.
- W4221001705 hasConceptScore W4221001705C94665300 @default.
- W4221001705 hasLocation W42210017051 @default.
- W4221001705 hasLocation W42210017052 @default.
- W4221001705 hasOpenAccess W4221001705 @default.
- W4221001705 hasPrimaryLocation W42210017051 @default.
- W4221001705 hasRelatedWork W2045070223 @default.
- W4221001705 hasRelatedWork W2069184423 @default.
- W4221001705 hasRelatedWork W2087887478 @default.
- W4221001705 hasRelatedWork W2121383808 @default.
- W4221001705 hasRelatedWork W2318106903 @default.
- W4221001705 hasRelatedWork W2561642321 @default.
- W4221001705 hasRelatedWork W2739219804 @default.
- W4221001705 hasRelatedWork W2761241319 @default.
- W4221001705 hasRelatedWork W3217740760 @default.
- W4221001705 hasRelatedWork W2187207551 @default.
- W4221001705 hasVolume "85" @default.
- W4221001705 isParatext "false" @default.