FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221002161> ?p ?o ?g. }

• W4221002161 endingPage "520" @default.
• W4221002161 startingPage "511" @default.
• W4221002161 abstract "Pancreatic cancer (PC) is exemplified by a complex immune-suppressive, fibrotic tumor microenvironment (TME), and aberrant expression of mucins. The constant crosstalk between cancer cells, cancer-associated fibroblasts (CAFs), and the immune cells mediated by the soluble factors and inflammatory mediators including cytokines, chemokines, reactive oxygen species (ROS) promote the dynamic temporal switch towards an immune-escape phenotype in the neoplastic cells and its microenvironment that bolsters disease progression. Chemokines have been studied in PC pathogenesis, albeit poorly in the context of mucins, tumor glycocalyx, and TME heterogeneity (CAFs and immune cells). With correlative analysis from PC patients’ transcriptome data, support from available literature, and scientific arguments-based speculative extrapolations in terms of disease pathogenesis, we have summarized in this review a comprehensive understanding of chemokine-mucinome interplay during stromal modulation and immune-suppression in PC. Future studies should focus on deciphering the complexities of chemokine-mediated control of glycocalyx maturation, immune infiltration, and CAF-associated immune suppression. Knowledge extracted from such studies will be beneficial to mechanistically correlate the mucin-chemokine abundance in serum versus pancreatic tumors of patients, which may aid in prognostication and stratification of PC patients for immunotherapy." @default.
• W4221002161 created "2022-04-03" @default.
• W4221002161 creator A5008895098 @default.
• W4221002161 creator A5010440741 @default.
• W4221002161 creator A5012159690 @default.
• W4221002161 creator A5023967002 @default.
• W4221002161 creator A5024831426 @default.
• W4221002161 creator A5085256777 @default.
• W4221002161 creator A5086534465 @default.
• W4221002161 date "2022-11-01" @default.
• W4221002161 modified "2023-10-15" @default.
• W4221002161 title "Chemokine-mucinome interplay in shaping the heterogeneous tumor microenvironment of pancreatic cancer" @default.
• W4221002161 cites W1182461782 @default.
• W4221002161 cites W1649213427 @default.
• W4221002161 cites W1967729931 @default.
• W4221002161 cites W1976031866 @default.
• W4221002161 cites W1985987855 @default.
• W4221002161 cites W1987690790 @default.
• W4221002161 cites W1994236457 @default.
• W4221002161 cites W2011597615 @default.
• W4221002161 cites W2014207594 @default.
• W4221002161 cites W2016329950 @default.
• W4221002161 cites W2019889666 @default.
• W4221002161 cites W2029841674 @default.
• W4221002161 cites W2038846025 @default.
• W4221002161 cites W2043107232 @default.
• W4221002161 cites W2046547919 @default.
• W4221002161 cites W2055183809 @default.
• W4221002161 cites W2059668347 @default.
• W4221002161 cites W2061710381 @default.
• W4221002161 cites W2064438446 @default.
• W4221002161 cites W2071682429 @default.
• W4221002161 cites W2076258083 @default.
• W4221002161 cites W2086834665 @default.
• W4221002161 cites W2088609559 @default.
• W4221002161 cites W2091854488 @default.
• W4221002161 cites W2096280264 @default.
• W4221002161 cites W2101350279 @default.
• W4221002161 cites W2101919878 @default.
• W4221002161 cites W2106632041 @default.
• W4221002161 cites W2107417920 @default.
• W4221002161 cites W2108775189 @default.
• W4221002161 cites W2112215926 @default.
• W4221002161 cites W2118742454 @default.
• W4221002161 cites W2137428636 @default.
• W4221002161 cites W2142644858 @default.
• W4221002161 cites W2147184466 @default.
• W4221002161 cites W2150312232 @default.
• W4221002161 cites W2156892677 @default.
• W4221002161 cites W2159803708 @default.
• W4221002161 cites W2165261531 @default.
• W4221002161 cites W2290698646 @default.
• W4221002161 cites W2326635547 @default.
• W4221002161 cites W2346435250 @default.
• W4221002161 cites W2416038770 @default.
• W4221002161 cites W2516359951 @default.
• W4221002161 cites W2570830222 @default.
• W4221002161 cites W2590390825 @default.
• W4221002161 cites W2591704778 @default.
• W4221002161 cites W2597652925 @default.
• W4221002161 cites W2748596787 @default.
• W4221002161 cites W2750644180 @default.
• W4221002161 cites W2778974161 @default.
• W4221002161 cites W2797069917 @default.
• W4221002161 cites W2807068765 @default.
• W4221002161 cites W2904890834 @default.
• W4221002161 cites W2908507139 @default.
• W4221002161 cites W2909703266 @default.
• W4221002161 cites W2913836031 @default.
• W4221002161 cites W2924483954 @default.
• W4221002161 cites W2936554489 @default.
• W4221002161 cites W2944176417 @default.
• W4221002161 cites W2959046636 @default.
• W4221002161 cites W2963936065 @default.
• W4221002161 cites W2976621710 @default.
• W4221002161 cites W3005533266 @default.
• W4221002161 cites W3007057280 @default.
• W4221002161 cites W3015058151 @default.
• W4221002161 cites W3016803713 @default.
• W4221002161 cites W3023998523 @default.
• W4221002161 cites W3025854932 @default.
• W4221002161 cites W3032158161 @default.
• W4221002161 cites W3081737350 @default.
• W4221002161 cites W3083980713 @default.
• W4221002161 cites W3093192089 @default.
• W4221002161 cites W3131248149 @default.
• W4221002161 cites W3159713086 @default.
• W4221002161 cites W3169276257 @default.
• W4221002161 cites W3169512085 @default.
• W4221002161 cites W3200323540 @default.
• W4221002161 cites W4211114435 @default.
• W4221002161 cites W4250676629 @default.
• W4221002161 doi "https://doi.org/10.1016/j.semcancer.2022.03.022" @default.
• W4221002161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35346803" @default.
• W4221002161 hasPublicationYear "2022" @default.
• W4221002161 type Work @default.
• W4221002161 citedByCount "9" @default.
• W4221002161 countsByYear W42210021612022 @default.

• next