Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221002849> ?p ?o ?g. }
- W4221002849 endingPage "81" @default.
- W4221002849 startingPage "43" @default.
- W4221002849 abstract "The molecular and cellular mechanisms by which alcohol produces its deleterious effects on neuronal networks are only now beginning to be understood. This review focused on alcohol-induced neurobiological alterations on neuronal network components underlying information processing, for further understanding of intellectual disability related to FASD. Abnormal neurodevelopmental events related to alcohol-damaged fetal brain included neurogenesis inhibition, aberrant migration, impaired differentiation, exacerbated apoptosis, impaired axon outgrowth and branching altering synaptogenesis and synaptic plasticity, abnormal GABAergic interneurons triggering synaptic inhibitory/excitatory imbalance, reduced myelinogenesis causing injured white matter in prefrontal lobe and atrophied corpus callosum compromising interhemispheric information transfer, the whole compromising neuronal network scaffolding which may lead to biased information processing with deficits in executive function. What added to these abnormalities are smaller gray matter and reduced hippocampus, resulting in cognition and memory failures. As a whole, these developmental disorders may underlie intellectual disability related to FASD. In rodents, these neuronal network components matured mainly during the second and third trimesters equivalents of human gestation. Transferability of results from animal to human was also discussed. It was hoped that the understanding of alcohol-induced neuronal networks failure mechanisms during the developing brain may lay a foundation for prospective new treatments and interventions." @default.
- W4221002849 created "2022-04-03" @default.
- W4221002849 creator A5007550422 @default.
- W4221002849 date "2022-01-01" @default.
- W4221002849 modified "2023-09-26" @default.
- W4221002849 title "Neurobiology of Neuronal Network Alteration in Intellectual Disability Related to Fetal Alcohol Spectrum Disorders" @default.
- W4221002849 cites W1483109784 @default.
- W4221002849 cites W1491178870 @default.
- W4221002849 cites W1493800420 @default.
- W4221002849 cites W1529535293 @default.
- W4221002849 cites W1534155286 @default.
- W4221002849 cites W1536160135 @default.
- W4221002849 cites W1555310782 @default.
- W4221002849 cites W1567716376 @default.
- W4221002849 cites W1582081614 @default.
- W4221002849 cites W1611867296 @default.
- W4221002849 cites W1641004652 @default.
- W4221002849 cites W1727961109 @default.
- W4221002849 cites W1762454906 @default.
- W4221002849 cites W1830240816 @default.
- W4221002849 cites W1833171476 @default.
- W4221002849 cites W183498517 @default.
- W4221002849 cites W1868621517 @default.
- W4221002849 cites W1886218212 @default.
- W4221002849 cites W1904935534 @default.
- W4221002849 cites W1919044814 @default.
- W4221002849 cites W1965892451 @default.
- W4221002849 cites W1966497206 @default.
- W4221002849 cites W1966888486 @default.
- W4221002849 cites W1967513977 @default.
- W4221002849 cites W1968899084 @default.
- W4221002849 cites W1969543645 @default.
- W4221002849 cites W1970382681 @default.
- W4221002849 cites W1971627886 @default.
- W4221002849 cites W1972451253 @default.
- W4221002849 cites W1974448056 @default.
- W4221002849 cites W1975521055 @default.
- W4221002849 cites W1975942624 @default.
- W4221002849 cites W1976053890 @default.
- W4221002849 cites W1978764694 @default.
- W4221002849 cites W1978987336 @default.
- W4221002849 cites W1979089991 @default.
- W4221002849 cites W1982720135 @default.
- W4221002849 cites W1983642713 @default.
- W4221002849 cites W1983752417 @default.
- W4221002849 cites W1986122705 @default.
- W4221002849 cites W1986920726 @default.
- W4221002849 cites W1989541294 @default.
- W4221002849 cites W1990140633 @default.
- W4221002849 cites W1990258769 @default.
- W4221002849 cites W1993911031 @default.
- W4221002849 cites W1994033808 @default.
- W4221002849 cites W1995958961 @default.
- W4221002849 cites W1996023160 @default.
- W4221002849 cites W1996309987 @default.
- W4221002849 cites W1996534902 @default.
- W4221002849 cites W1996565528 @default.
- W4221002849 cites W1996905357 @default.
- W4221002849 cites W1997011037 @default.
- W4221002849 cites W1997860363 @default.
- W4221002849 cites W1998311675 @default.
- W4221002849 cites W1998354909 @default.
- W4221002849 cites W1998988029 @default.
- W4221002849 cites W2002614030 @default.
- W4221002849 cites W2003129774 @default.
- W4221002849 cites W2003342248 @default.
- W4221002849 cites W2003813521 @default.
- W4221002849 cites W2005134643 @default.
- W4221002849 cites W2005700029 @default.
- W4221002849 cites W2005826876 @default.
- W4221002849 cites W2008151965 @default.
- W4221002849 cites W2010458479 @default.
- W4221002849 cites W2010844786 @default.
- W4221002849 cites W2012048336 @default.
- W4221002849 cites W2015830285 @default.
- W4221002849 cites W2016208760 @default.
- W4221002849 cites W2017124601 @default.
- W4221002849 cites W2022834548 @default.
- W4221002849 cites W2027365841 @default.
- W4221002849 cites W2029322090 @default.
- W4221002849 cites W2029815010 @default.
- W4221002849 cites W2030338901 @default.
- W4221002849 cites W2030340360 @default.
- W4221002849 cites W2034359129 @default.
- W4221002849 cites W2034798927 @default.
- W4221002849 cites W2036337207 @default.
- W4221002849 cites W2036909204 @default.
- W4221002849 cites W2037659994 @default.
- W4221002849 cites W2039508969 @default.
- W4221002849 cites W2040056946 @default.
- W4221002849 cites W2040323668 @default.
- W4221002849 cites W2040808060 @default.
- W4221002849 cites W2044648154 @default.
- W4221002849 cites W2045337982 @default.
- W4221002849 cites W2047463569 @default.
- W4221002849 cites W2047937248 @default.
- W4221002849 cites W2050337050 @default.
- W4221002849 cites W2051961815 @default.