FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221003669> ?p ?o ?g. }

• W4221003669 endingPage "120521" @default.
• W4221003669 startingPage "120521" @default.
• W4221003669 abstract "Maternal undernutrition during pregnancy disrupts both fetal growth and development with perturbations to certain physiological processes within the maternal-fetal-placental unit, including metabolic function. However, it is unknown if hypoglycemia during pregnancy alters maternal-fetal-placental drug metabolism as mediated by cytochrome P450 (CYP) enzymes. Despite this, hypoglycemia reduces CYP enzyme activity in non-pregnant animals. We therefore hypothesised that in a sheep model of hypoglycemia induced by late gestation undernutrition (LGUN), maternal-fetal-placental CYP activity would be reduced, and that fetal glucose infusion (LGUN+G) would rescue reduced CYP activity.At 115d gestation (term, 150d), ewes were allocated to control (100% metabolic energy requirement (MER); n = 11), LGUN (50% MER; n = 7) or LGUN+G (50% MER + fetal glucose infusion; n = 6) and maintained on their diets until post-mortem. Maternal-fetal-placental CYP activity assays were performed at 131-133d gestation. Microsomes were isolated from placenta and fetal liver collected at 139-142d gestation and incubated with CYP-specific probe drugs. Metabolite concentrations were measured using Liquid Chromatography - tandem mass spectrometry (LC-MS/MS).CYP2C19 and CYP3A were undetectable in placenta or fetal liver, and CYP1A2 was undetectable in the fetal liver. Placental-specific CYP1A2 and CYP2D6 activity and hepatic-specific CYP2D6 activity were unaffected by LGUN. Maternal-fetal-placental CYP1A2 activity was reduced in response to LGUN in the maternal compartment only.Reduced maternal-fetal-placental CYP1A2 activity, but not placental-specific CYP1A2 activity, may lead to the developing fetus being exposed to increased concentrations of CYP1A2-specific substrates and suggests further consideration of drug dosing is required in instances of late gestation maternal undernutrition." @default.
• W4221003669 created "2022-04-03" @default.
• W4221003669 creator A5052330076 @default.
• W4221003669 creator A5057731856 @default.
• W4221003669 creator A5062333046 @default.
• W4221003669 creator A5064151397 @default.
• W4221003669 creator A5067461242 @default.
• W4221003669 date "2022-06-01" @default.
• W4221003669 modified "2023-09-23" @default.
• W4221003669 title "Maternal-placental-fetal drug metabolism is altered by late gestation undernutrition in the pregnant ewe" @default.
• W4221003669 cites W1001196264 @default.
• W4221003669 cites W1576939133 @default.
• W4221003669 cites W1652213260 @default.
• W4221003669 cites W1967145102 @default.
• W4221003669 cites W1971687097 @default.
• W4221003669 cites W1997293235 @default.
• W4221003669 cites W2001867509 @default.
• W4221003669 cites W2002917015 @default.
• W4221003669 cites W2010427019 @default.
• W4221003669 cites W2015946435 @default.
• W4221003669 cites W2021362162 @default.
• W4221003669 cites W2024331080 @default.
• W4221003669 cites W2027905723 @default.
• W4221003669 cites W2030145911 @default.
• W4221003669 cites W2030474337 @default.
• W4221003669 cites W2034182975 @default.
• W4221003669 cites W2037885071 @default.
• W4221003669 cites W2042764317 @default.
• W4221003669 cites W2054055548 @default.
• W4221003669 cites W2057868132 @default.
• W4221003669 cites W2061781805 @default.
• W4221003669 cites W2063986174 @default.
• W4221003669 cites W2064171903 @default.
• W4221003669 cites W2068708003 @default.
• W4221003669 cites W2068780263 @default.
• W4221003669 cites W2069598643 @default.
• W4221003669 cites W2094145283 @default.
• W4221003669 cites W2095234730 @default.
• W4221003669 cites W2097376643 @default.
• W4221003669 cites W2097498234 @default.
• W4221003669 cites W2103433863 @default.
• W4221003669 cites W2117192628 @default.
• W4221003669 cites W2122546244 @default.
• W4221003669 cites W2139548552 @default.
• W4221003669 cites W2158847005 @default.
• W4221003669 cites W2170501199 @default.
• W4221003669 cites W2282479146 @default.
• W4221003669 cites W2288353973 @default.
• W4221003669 cites W2419293593 @default.
• W4221003669 cites W2430345061 @default.
• W4221003669 cites W2463560934 @default.
• W4221003669 cites W2560621814 @default.
• W4221003669 cites W2740817844 @default.
• W4221003669 cites W2805738262 @default.
• W4221003669 cites W2808247149 @default.
• W4221003669 cites W2944034338 @default.
• W4221003669 cites W2955973393 @default.
• W4221003669 cites W2986454255 @default.
• W4221003669 cites W3007221657 @default.
• W4221003669 cites W3025902752 @default.
• W4221003669 cites W3045393712 @default.
• W4221003669 cites W3047320223 @default.
• W4221003669 cites W3092388556 @default.
• W4221003669 cites W3093395832 @default.
• W4221003669 cites W3119383839 @default.
• W4221003669 cites W3196403775 @default.
• W4221003669 cites W3196644657 @default.
• W4221003669 cites W3201810860 @default.
• W4221003669 cites W3212700654 @default.
• W4221003669 cites W4246235415 @default.
• W4221003669 cites W4296816736 @default.
• W4221003669 cites W2586785266 @default.
• W4221003669 doi "https://doi.org/10.1016/j.lfs.2022.120521" @default.
• W4221003669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35367241" @default.
• W4221003669 hasPublicationYear "2022" @default.
• W4221003669 type Work @default.
• W4221003669 citedByCount "2" @default.
• W4221003669 countsByYear W42210036692023 @default.
• W4221003669 crossrefType "journal-article" @default.
• W4221003669 hasAuthorship W4221003669A5052330076 @default.
• W4221003669 hasAuthorship W4221003669A5057731856 @default.
• W4221003669 hasAuthorship W4221003669A5062333046 @default.
• W4221003669 hasAuthorship W4221003669A5064151397 @default.
• W4221003669 hasAuthorship W4221003669A5067461242 @default.
• W4221003669 hasBestOaLocation W42210036692 @default.
• W4221003669 hasConcept C126322002 @default.
• W4221003669 hasConcept C134018914 @default.
• W4221003669 hasConcept C172680121 @default.
• W4221003669 hasConcept C2776953305 @default.
• W4221003669 hasConcept C2779234561 @default.
• W4221003669 hasConcept C46973012 @default.
• W4221003669 hasConcept C526171541 @default.
• W4221003669 hasConcept C54355233 @default.
• W4221003669 hasConcept C62231903 @default.
• W4221003669 hasConcept C71924100 @default.
• W4221003669 hasConcept C86745063 @default.
• W4221003669 hasConcept C86803240 @default.
• W4221003669 hasConceptScore W4221003669C126322002 @default.

• next