Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221004097> ?p ?o ?g. }
- W4221004097 abstract "SignificanceSTAT3 (signal transducer and activator of transcription 3) is a master transcription factor that organizes cellular responses to cytokines and growth factors and is implicated in inflammatory disorders. STAT3 is a well-recognized therapeutic target for human cancer and inflammatory disorders, but how its function is regulated in a cell type-specific manner has been a major outstanding question. We discovered that Stat3 imposes self-directed regulation through controlling transcription of its own regulator homeodomain-interacting protein kinase 2 (Hipk2) in a T helper 17 (Th17) cell-specific manner. Our validation of the functional importance of the Stat3-Hipk2 axis in Th17 cell development in the pathogenesis of T cell-induced colitis in mice suggests an approach to therapeutically treat inflammatory bowel diseases that currently lack a safe and effective therapy." @default.
- W4221004097 created "2022-04-03" @default.
- W4221004097 creator A5009921555 @default.
- W4221004097 creator A5025947755 @default.
- W4221004097 creator A5027894107 @default.
- W4221004097 creator A5028065092 @default.
- W4221004097 creator A5030472512 @default.
- W4221004097 creator A5030785720 @default.
- W4221004097 creator A5032295040 @default.
- W4221004097 creator A5035506234 @default.
- W4221004097 creator A5044086880 @default.
- W4221004097 creator A5049719429 @default.
- W4221004097 creator A5053447705 @default.
- W4221004097 creator A5056104796 @default.
- W4221004097 creator A5057300440 @default.
- W4221004097 creator A5066515959 @default.
- W4221004097 creator A5066838059 @default.
- W4221004097 creator A5074459288 @default.
- W4221004097 creator A5081368577 @default.
- W4221004097 creator A5082792278 @default.
- W4221004097 date "2022-03-28" @default.
- W4221004097 modified "2023-09-26" @default.
- W4221004097 title "HIPK2 directs cell type–specific regulation of STAT3 transcriptional activity in Th17 cell differentiation" @default.
- W4221004097 cites W1434467868 @default.
- W4221004097 cites W1504831700 @default.
- W4221004097 cites W1516263086 @default.
- W4221004097 cites W1777296950 @default.
- W4221004097 cites W1981037015 @default.
- W4221004097 cites W1982085112 @default.
- W4221004097 cites W1993034428 @default.
- W4221004097 cites W1995957006 @default.
- W4221004097 cites W2011882192 @default.
- W4221004097 cites W2014750930 @default.
- W4221004097 cites W2016850513 @default.
- W4221004097 cites W2021340905 @default.
- W4221004097 cites W2022917731 @default.
- W4221004097 cites W2028544780 @default.
- W4221004097 cites W2044183928 @default.
- W4221004097 cites W2047409274 @default.
- W4221004097 cites W2050010024 @default.
- W4221004097 cites W2055187132 @default.
- W4221004097 cites W2058487327 @default.
- W4221004097 cites W2064264167 @default.
- W4221004097 cites W2072339454 @default.
- W4221004097 cites W2073851402 @default.
- W4221004097 cites W2078776487 @default.
- W4221004097 cites W2092760439 @default.
- W4221004097 cites W2105137499 @default.
- W4221004097 cites W2112866067 @default.
- W4221004097 cites W2132795867 @default.
- W4221004097 cites W2142017607 @default.
- W4221004097 cites W2144898082 @default.
- W4221004097 cites W2145912313 @default.
- W4221004097 cites W2155779547 @default.
- W4221004097 cites W2163542216 @default.
- W4221004097 cites W2441946812 @default.
- W4221004097 cites W2591379092 @default.
- W4221004097 cites W2592276570 @default.
- W4221004097 cites W2593538080 @default.
- W4221004097 cites W2776663677 @default.
- W4221004097 cites W2786987313 @default.
- W4221004097 cites W2940742708 @default.
- W4221004097 cites W3044903726 @default.
- W4221004097 doi "https://doi.org/10.1073/pnas.2117112119" @default.
- W4221004097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35344430" @default.
- W4221004097 hasPublicationYear "2022" @default.
- W4221004097 type Work @default.
- W4221004097 citedByCount "1" @default.
- W4221004097 countsByYear W42210040972022 @default.
- W4221004097 crossrefType "journal-article" @default.
- W4221004097 hasAuthorship W4221004097A5009921555 @default.
- W4221004097 hasAuthorship W4221004097A5025947755 @default.
- W4221004097 hasAuthorship W4221004097A5027894107 @default.
- W4221004097 hasAuthorship W4221004097A5028065092 @default.
- W4221004097 hasAuthorship W4221004097A5030472512 @default.
- W4221004097 hasAuthorship W4221004097A5030785720 @default.
- W4221004097 hasAuthorship W4221004097A5032295040 @default.
- W4221004097 hasAuthorship W4221004097A5035506234 @default.
- W4221004097 hasAuthorship W4221004097A5044086880 @default.
- W4221004097 hasAuthorship W4221004097A5049719429 @default.
- W4221004097 hasAuthorship W4221004097A5053447705 @default.
- W4221004097 hasAuthorship W4221004097A5056104796 @default.
- W4221004097 hasAuthorship W4221004097A5057300440 @default.
- W4221004097 hasAuthorship W4221004097A5066515959 @default.
- W4221004097 hasAuthorship W4221004097A5066838059 @default.
- W4221004097 hasAuthorship W4221004097A5074459288 @default.
- W4221004097 hasAuthorship W4221004097A5081368577 @default.
- W4221004097 hasAuthorship W4221004097A5082792278 @default.
- W4221004097 hasBestOaLocation W42210040971 @default.
- W4221004097 hasConcept C104317684 @default.
- W4221004097 hasConcept C148738053 @default.
- W4221004097 hasConcept C1491633281 @default.
- W4221004097 hasConcept C171958077 @default.
- W4221004097 hasConcept C189014844 @default.
- W4221004097 hasConcept C203014093 @default.
- W4221004097 hasConcept C2778277574 @default.
- W4221004097 hasConcept C2778923194 @default.
- W4221004097 hasConcept C502942594 @default.
- W4221004097 hasConcept C54355233 @default.
- W4221004097 hasConcept C62112901 @default.