Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221004841> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4221004841 endingPage "2465" @default.
- W4221004841 startingPage "2448" @default.
- W4221004841 abstract "Abstract Treatment noncompliance often occurs in longitudinal randomized controlled trials (RCTs) on human subjects, and can greatly complicate treatment effect assessment. The complier average causal effect (CACE) informs the intervention efficacy for the subpopulation who would comply regardless of assigned treatment and has been considered as patient‐oriented treatment effects of interest in the presence of noncompliance. Real‐world RCTs evaluating multifaceted interventions often employ multiple study endpoints to measure treatment success. In such trials, limited sample sizes, low compliance rates, and small to moderate effect sizes on individual endpoints can significantly reduce the power to detect CACE when these correlated endpoints are analyzed separately. To overcome the challenge, we develop a multivariate longitudinal potential outcome model with stratification on latent compliance types to efficiently assess multivariate CACEs (MCACE) by combining information across multiple endpoints and visits. Evaluation using simulation data shows a significant increase in the estimation efficiency with the MCACE model, including up to 50% reduction in standard errors (SEs) of CACE estimates and 1‐fold increase in the power to detect CACE. Finally, we apply the proposed MCACE model to an RCT on Arthritis Health Journal online tool. Results show that the MCACE analysis detects significant and beneficial intervention effects on two of the six endpoints while estimating CACEs for these endpoints separately fail to detect treatment effect on any endpoint." @default.
- W4221004841 created "2022-04-03" @default.
- W4221004841 creator A5035823220 @default.
- W4221004841 creator A5047849595 @default.
- W4221004841 creator A5052877885 @default.
- W4221004841 date "2022-03-10" @default.
- W4221004841 modified "2023-10-02" @default.
- W4221004841 title "Assessing complier average causal effects from longitudinal trials with multiple endpoints and treatment noncompliance: An application to a study of Arthritis Health Journal" @default.
- W4221004841 cites W1512762145 @default.
- W4221004841 cites W1978396264 @default.
- W4221004841 cites W1996612038 @default.
- W4221004841 cites W2003231569 @default.
- W4221004841 cites W2016729144 @default.
- W4221004841 cites W2030623600 @default.
- W4221004841 cites W2064790857 @default.
- W4221004841 cites W2069068974 @default.
- W4221004841 cites W2082246284 @default.
- W4221004841 cites W2104780889 @default.
- W4221004841 cites W2127571115 @default.
- W4221004841 cites W2132759441 @default.
- W4221004841 cites W2135444901 @default.
- W4221004841 cites W2139309125 @default.
- W4221004841 cites W2165656368 @default.
- W4221004841 cites W2313015974 @default.
- W4221004841 cites W2314734263 @default.
- W4221004841 cites W3150893739 @default.
- W4221004841 doi "https://doi.org/10.1002/sim.9364" @default.
- W4221004841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35274333" @default.
- W4221004841 hasPublicationYear "2022" @default.
- W4221004841 type Work @default.
- W4221004841 citedByCount "3" @default.
- W4221004841 countsByYear W42210048412023 @default.
- W4221004841 crossrefType "journal-article" @default.
- W4221004841 hasAuthorship W4221004841A5035823220 @default.
- W4221004841 hasAuthorship W4221004841A5047849595 @default.
- W4221004841 hasAuthorship W4221004841A5052877885 @default.
- W4221004841 hasBestOaLocation W42210048412 @default.
- W4221004841 hasConcept C105795698 @default.
- W4221004841 hasConcept C126322002 @default.
- W4221004841 hasConcept C129848803 @default.
- W4221004841 hasConcept C142724271 @default.
- W4221004841 hasConcept C149782125 @default.
- W4221004841 hasConcept C158600405 @default.
- W4221004841 hasConcept C161584116 @default.
- W4221004841 hasConcept C168563851 @default.
- W4221004841 hasConcept C203092338 @default.
- W4221004841 hasConcept C33923547 @default.
- W4221004841 hasConcept C535046627 @default.
- W4221004841 hasConcept C71924100 @default.
- W4221004841 hasConcept C96608239 @default.
- W4221004841 hasConceptScore W4221004841C105795698 @default.
- W4221004841 hasConceptScore W4221004841C126322002 @default.
- W4221004841 hasConceptScore W4221004841C129848803 @default.
- W4221004841 hasConceptScore W4221004841C142724271 @default.
- W4221004841 hasConceptScore W4221004841C149782125 @default.
- W4221004841 hasConceptScore W4221004841C158600405 @default.
- W4221004841 hasConceptScore W4221004841C161584116 @default.
- W4221004841 hasConceptScore W4221004841C168563851 @default.
- W4221004841 hasConceptScore W4221004841C203092338 @default.
- W4221004841 hasConceptScore W4221004841C33923547 @default.
- W4221004841 hasConceptScore W4221004841C535046627 @default.
- W4221004841 hasConceptScore W4221004841C71924100 @default.
- W4221004841 hasConceptScore W4221004841C96608239 @default.
- W4221004841 hasFunder F4320332161 @default.
- W4221004841 hasFunder F4320334593 @default.
- W4221004841 hasFunder F4320334617 @default.
- W4221004841 hasIssue "13" @default.
- W4221004841 hasLocation W42210048411 @default.
- W4221004841 hasLocation W42210048412 @default.
- W4221004841 hasLocation W42210048413 @default.
- W4221004841 hasOpenAccess W4221004841 @default.
- W4221004841 hasPrimaryLocation W42210048411 @default.
- W4221004841 hasRelatedWork W2011680018 @default.
- W4221004841 hasRelatedWork W2022404837 @default.
- W4221004841 hasRelatedWork W2147231409 @default.
- W4221004841 hasRelatedWork W2773514871 @default.
- W4221004841 hasRelatedWork W2793775341 @default.
- W4221004841 hasRelatedWork W2952843659 @default.
- W4221004841 hasRelatedWork W3084428574 @default.
- W4221004841 hasRelatedWork W3137029931 @default.
- W4221004841 hasRelatedWork W4245099416 @default.
- W4221004841 hasRelatedWork W4382599617 @default.
- W4221004841 hasVolume "41" @default.
- W4221004841 isParatext "false" @default.
- W4221004841 isRetracted "false" @default.
- W4221004841 workType "article" @default.