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- W4221004927 endingPage "101612" @default.
- W4221004927 startingPage "101612" @default.
- W4221004927 abstract "Alzheimer's disease (AD) is a well-known neurodegenerative disease characterized by the presence of two main hallmarks - Tau hyperphosphorylation and Aβ deposits. Notwithstanding, in the last few years the scientific evidence about the drivers of AD have been changing and nowadays age-related vascular alterations and several cardiovascular risk factors have been shown to trigger the development of AD. In this context, drugs targeting the Renin Angiotensin System (RAS), commonly used for the treatment of hypertension, are evidencing a high potential to delay AD development due to their action on brain RAS. Indeed, the ACE 1/Ang II/AT1R axis is believed to be upregulated in AD and to be responsible for deleterious effects such as increased oxidative stress, neuroinflammation, blood-brain barrier (BBB) hyperpermeability, astrocytes dysfunction and a decrease in cerebral blood flow. In contrast, the alternative axis - ACE 1/Ang II/AT2R; ACE 2/Ang (1-7)/MasR; Ang IV/ AT4R(IRAP) - seems to counterbalance the deleterious effects of the principal axis and to exert beneficial effects on memory and cognition. Accordingly, retrospective studies demonstrate a reduced risk of developing AD among people taking RAS medication as well as several in vitro and in vivo pre-clinical studies as it is herein critically reviewed. In this review, we first revise, at a glance, the pathophysiology of AD focused on its classic hallmarks. Secondly, an overview about the impact of the RAS on the pathophysiology of AD is also provided, focused on their four essential axes ACE 1/Ang II/AT2R; ACE 2/Ang (1-7)/MasR; Ang IV/ AT4R(IRAP) and ACE 1/Ang II/AT1R. Finally, the therapeutic potential of available drugs targeting RAS on AD, namely angiotensin II receptor blockers (ARBs) and angiotensin converting enzyme inhibitors (ACEIs), is highlighted and data supporting this hope will be presented, from in vitro and in vivo pre-clinical to clinical studies." @default.
- W4221004927 created "2022-04-03" @default.
- W4221004927 creator A5002578972 @default.
- W4221004927 creator A5005031358 @default.
- W4221004927 creator A5005211993 @default.
- W4221004927 creator A5007472451 @default.
- W4221004927 creator A5031340729 @default.
- W4221004927 creator A5055021929 @default.
- W4221004927 creator A5056796479 @default.
- W4221004927 date "2022-05-01" @default.
- W4221004927 modified "2023-10-12" @default.
- W4221004927 title "Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer’s disease: Past, present and future" @default.
- W4221004927 cites W10316846 @default.
- W4221004927 cites W113185000 @default.
- W4221004927 cites W1536326499 @default.
- W4221004927 cites W1547520663 @default.
- W4221004927 cites W1555597750 @default.
- W4221004927 cites W1569630040 @default.
- W4221004927 cites W1653750413 @default.
- W4221004927 cites W1736389176 @default.
- W4221004927 cites W1828947725 @default.
- W4221004927 cites W1835154286 @default.
- W4221004927 cites W1841772591 @default.
- W4221004927 cites W1892097089 @default.
- W4221004927 cites W1898219529 @default.
- W4221004927 cites W1922733151 @default.
- W4221004927 cites W1967645451 @default.
- W4221004927 cites W1968900405 @default.
- W4221004927 cites W1969501720 @default.
- W4221004927 cites W1973755223 @default.
- W4221004927 cites W1974305753 @default.
- W4221004927 cites W1974985368 @default.
- W4221004927 cites W1975031289 @default.
- W4221004927 cites W1978701028 @default.
- W4221004927 cites W1980243405 @default.
- W4221004927 cites W1981132320 @default.
- W4221004927 cites W1982200175 @default.
- W4221004927 cites W1984227891 @default.
- W4221004927 cites W1988655607 @default.
- W4221004927 cites W1992893126 @default.
- W4221004927 cites W1993103089 @default.
- W4221004927 cites W1994456985 @default.
- W4221004927 cites W1994546246 @default.
- W4221004927 cites W1995817686 @default.
- W4221004927 cites W1996241810 @default.
- W4221004927 cites W1999061258 @default.
- W4221004927 cites W2000362399 @default.
- W4221004927 cites W2001895854 @default.
- W4221004927 cites W2003159190 @default.
- W4221004927 cites W2003923036 @default.
- W4221004927 cites W2004405731 @default.
- W4221004927 cites W2004554108 @default.
- W4221004927 cites W2005585462 @default.
- W4221004927 cites W2006436888 @default.
- W4221004927 cites W2007244994 @default.
- W4221004927 cites W2009194462 @default.
- W4221004927 cites W2012358869 @default.
- W4221004927 cites W2013230887 @default.
- W4221004927 cites W2015306208 @default.
- W4221004927 cites W2018023030 @default.
- W4221004927 cites W2019077981 @default.
- W4221004927 cites W2020423006 @default.
- W4221004927 cites W2023740999 @default.
- W4221004927 cites W2024757236 @default.
- W4221004927 cites W2029075996 @default.
- W4221004927 cites W2030568693 @default.
- W4221004927 cites W2030616110 @default.
- W4221004927 cites W2031017779 @default.
- W4221004927 cites W2035747909 @default.
- W4221004927 cites W2037581474 @default.
- W4221004927 cites W2037773920 @default.
- W4221004927 cites W2040277027 @default.
- W4221004927 cites W2041589863 @default.
- W4221004927 cites W2044936845 @default.
- W4221004927 cites W2046212966 @default.
- W4221004927 cites W2047430236 @default.
- W4221004927 cites W2048748448 @default.
- W4221004927 cites W2051393086 @default.
- W4221004927 cites W2051464023 @default.
- W4221004927 cites W2052039715 @default.
- W4221004927 cites W2052321977 @default.
- W4221004927 cites W2052427120 @default.
- W4221004927 cites W2053091943 @default.
- W4221004927 cites W2054031839 @default.
- W4221004927 cites W2055646886 @default.
- W4221004927 cites W2057441702 @default.
- W4221004927 cites W2060853617 @default.
- W4221004927 cites W2061411812 @default.
- W4221004927 cites W2062720767 @default.
- W4221004927 cites W2063503631 @default.
- W4221004927 cites W2064127325 @default.
- W4221004927 cites W2065143832 @default.
- W4221004927 cites W2067432590 @default.
- W4221004927 cites W2067756041 @default.
- W4221004927 cites W2067830186 @default.
- W4221004927 cites W2069140826 @default.
- W4221004927 cites W2070126811 @default.
- W4221004927 cites W2071762923 @default.