Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221008030> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4221008030 endingPage "11" @default.
- W4221008030 startingPage "1" @default.
- W4221008030 abstract "Polypyrimidine tract-binding protein 1 (PTBP1) is an RNA-binding protein, which plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. However, little was known about the correlation between PTBP1 and glioma and its prognostic significance in glioma patients. Our aim was to investigate the expression, functional role, and prognostic value of PTBP1 in glioma.We explored the expression of PTBP1 protein using immunohistochemistry in 150 adult malignant glioma tissues and 20 normal brain tissues and evaluated its association with clinicopathological parameters by chi-square test. Kaplan-Meier method was used to evaluate the prognostic effect of PTBP1 in glioma. Univariate/multivariate Cox analyses were used to identify independent prognostic factors. Transcriptional regulation network was constructed based on differentially expressed genes (DEGs) of PTBP1 from TCGA/CGGA database. GO and KEGG enrichment analyses were used to explore the function and pathways of DEGs.Out of the 150 malignant glioma tissues (60 LGG and 90 GBMs) and 20 normal brain tissues in our cohort, PTBP1 protein was high expressed in glioma tissues (79/150, 52.7%), but no expression was detected in normal brain tissues (0/20, 0%). The expression of PTBP1 was significantly higher in GBMs (P < 0.001). More than half of GBMs (62/90, 68.9%) were PTBP1 high expression. Chi-square test showed that the expression of PTBP1 was correlated with patient age, WHO grade, Ki-67 index, and IDH status. High expression of PTBP1 was significantly associated with poor prognosis in glioma, and it was an independent risk factor in glioma patients. Furthermore, we shed light on the underlying mechanism of PTBP1 by constructing a miR-218-TCF3-PTBP1 transcriptional network in glioma.PTBP1 was high expressed in glioma, and it significantly correlated with poor prognosis, suggesting a potential therapeutic target for glioma, particularly for GBM." @default.
- W4221008030 created "2022-04-03" @default.
- W4221008030 creator A5022802322 @default.
- W4221008030 creator A5025602649 @default.
- W4221008030 creator A5033760090 @default.
- W4221008030 creator A5037639447 @default.
- W4221008030 creator A5038128649 @default.
- W4221008030 creator A5080321263 @default.
- W4221008030 creator A5080979034 @default.
- W4221008030 creator A5084568848 @default.
- W4221008030 date "2022-03-08" @default.
- W4221008030 modified "2023-09-30" @default.
- W4221008030 title "PTBP1 is a Novel Poor Prognostic Factor for Glioma" @default.
- W4221008030 cites W1567606707 @default.
- W4221008030 cites W1833453044 @default.
- W4221008030 cites W2001398820 @default.
- W4221008030 cites W2011920499 @default.
- W4221008030 cites W2013359619 @default.
- W4221008030 cites W2025183726 @default.
- W4221008030 cites W2094887188 @default.
- W4221008030 cites W2109200119 @default.
- W4221008030 cites W2115862526 @default.
- W4221008030 cites W2133396831 @default.
- W4221008030 cites W2145757909 @default.
- W4221008030 cites W2155804510 @default.
- W4221008030 cites W2165090547 @default.
- W4221008030 cites W2788015434 @default.
- W4221008030 cites W2790197340 @default.
- W4221008030 cites W2948850524 @default.
- W4221008030 cites W3173512765 @default.
- W4221008030 doi "https://doi.org/10.1155/2022/7590997" @default.
- W4221008030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35299889" @default.
- W4221008030 hasPublicationYear "2022" @default.
- W4221008030 type Work @default.
- W4221008030 citedByCount "2" @default.
- W4221008030 countsByYear W42210080302023 @default.
- W4221008030 crossrefType "journal-article" @default.
- W4221008030 hasAuthorship W4221008030A5022802322 @default.
- W4221008030 hasAuthorship W4221008030A5025602649 @default.
- W4221008030 hasAuthorship W4221008030A5033760090 @default.
- W4221008030 hasAuthorship W4221008030A5037639447 @default.
- W4221008030 hasAuthorship W4221008030A5038128649 @default.
- W4221008030 hasAuthorship W4221008030A5080321263 @default.
- W4221008030 hasAuthorship W4221008030A5080979034 @default.
- W4221008030 hasAuthorship W4221008030A5084568848 @default.
- W4221008030 hasBestOaLocation W42210080301 @default.
- W4221008030 hasConcept C104317684 @default.
- W4221008030 hasConcept C105580179 @default.
- W4221008030 hasConcept C150194340 @default.
- W4221008030 hasConcept C152724338 @default.
- W4221008030 hasConcept C162317418 @default.
- W4221008030 hasConcept C194583182 @default.
- W4221008030 hasConcept C203014093 @default.
- W4221008030 hasConcept C204232928 @default.
- W4221008030 hasConcept C2777793812 @default.
- W4221008030 hasConcept C2778227246 @default.
- W4221008030 hasConcept C41282012 @default.
- W4221008030 hasConcept C502942594 @default.
- W4221008030 hasConcept C54355233 @default.
- W4221008030 hasConcept C54458228 @default.
- W4221008030 hasConcept C67705224 @default.
- W4221008030 hasConcept C86803240 @default.
- W4221008030 hasConceptScore W4221008030C104317684 @default.
- W4221008030 hasConceptScore W4221008030C105580179 @default.
- W4221008030 hasConceptScore W4221008030C150194340 @default.
- W4221008030 hasConceptScore W4221008030C152724338 @default.
- W4221008030 hasConceptScore W4221008030C162317418 @default.
- W4221008030 hasConceptScore W4221008030C194583182 @default.
- W4221008030 hasConceptScore W4221008030C203014093 @default.
- W4221008030 hasConceptScore W4221008030C204232928 @default.
- W4221008030 hasConceptScore W4221008030C2777793812 @default.
- W4221008030 hasConceptScore W4221008030C2778227246 @default.
- W4221008030 hasConceptScore W4221008030C41282012 @default.
- W4221008030 hasConceptScore W4221008030C502942594 @default.
- W4221008030 hasConceptScore W4221008030C54355233 @default.
- W4221008030 hasConceptScore W4221008030C54458228 @default.
- W4221008030 hasConceptScore W4221008030C67705224 @default.
- W4221008030 hasConceptScore W4221008030C86803240 @default.
- W4221008030 hasLocation W42210080301 @default.
- W4221008030 hasLocation W42210080302 @default.
- W4221008030 hasLocation W42210080303 @default.
- W4221008030 hasOpenAccess W4221008030 @default.
- W4221008030 hasPrimaryLocation W42210080301 @default.
- W4221008030 hasRelatedWork W1182567748 @default.
- W4221008030 hasRelatedWork W1759605135 @default.
- W4221008030 hasRelatedWork W2021018226 @default.
- W4221008030 hasRelatedWork W2347399158 @default.
- W4221008030 hasRelatedWork W2418342455 @default.
- W4221008030 hasRelatedWork W2735479569 @default.
- W4221008030 hasRelatedWork W3032721417 @default.
- W4221008030 hasRelatedWork W3174191192 @default.
- W4221008030 hasRelatedWork W4210387296 @default.
- W4221008030 hasRelatedWork W4378839777 @default.
- W4221008030 hasVolume "2022" @default.
- W4221008030 isParatext "false" @default.
- W4221008030 isRetracted "false" @default.
- W4221008030 workType "article" @default.