FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221011736> ?p ?o ?g. }

• W4221011736 abstract "This study aimed to investigate the effect of OCT4&SOX2 specific cytotoxic T lymphocytes (CTLs) plus programmed cell death protein-1 (PD-1) inhibitor (nivolumab) on treating breast cancer stem-like cells (BCSCs) in vitro and drug-resistance breast cancer (DRBC) mice in vivo.In total, 160 breast cancer patients were enrolled following the immunofluorescence assay to detect tumor OCT4 and SOX2 expressions. CD154-activated B cells were co-cultured with CD8+ T cells (from breast cancer patients) in the presence of OCT4&SOX2 peptides, CMV pp65 peptides (negative control), and no peptides (normal control). MCF7-BCSCs were constructed by drug-resistance experiment and sphere-formation assay, then DRBC mice were constructed by planting MCF7-BCSCs. Subsequently, different doses of OCT4&SOX2 CTLs and PD-1 inhibitor (nivolumab) were used to treat MCF7-BCSCs and DRBC mice.OCT4 and SOX2 correlated with poor differentiation, more advanced stage, and worse prognosis in breast cancer patients. In vitro, OCT4&SOX2 CTLs with effector-target ratio (ETR) 5:1, 10:1 and 20:1 presented with increased cytotoxic activity compared to CMV pp65 CTLs with ETR 20:1 (negative control) and Control CTLs with ETR 20:1 (normal control) on killing MCF7-BCSCs. Besides, PD-1 inhibitor (nivolumab) improved the cytotoxic activity of OCT4&SOX2 CTLs against MCF7-BCSCs in a dose-dependent manner. In vivo, OCT4&SOX2 CTLs plus PD-1 inhibitor (nivolumab) decreased tumor volume and tumor weight while increased tumor apoptosis rate compared to OCT4&SOX2 CTLs alone, PD-1 inhibitor (nivolumab) alone, and control.OCT4&SOX2 CTLs exhibit good efficiency and synergize PD-1 inhibitor (nivolumab) in treating BCSCs and DRBC." @default.
• W4221011736 created "2022-04-03" @default.
• W4221011736 creator A5029225084 @default.
• W4221011736 creator A5031610830 @default.
• W4221011736 creator A5033990407 @default.
• W4221011736 creator A5044137903 @default.
• W4221011736 creator A5053204257 @default.
• W4221011736 date "2022-03-24" @default.
• W4221011736 modified "2023-10-18" @default.
• W4221011736 title "OCT4 and SOX2 Specific Cytotoxic T Cells Exhibit Not Only Good Efficiency but Also Synergize PD-1 Inhibitor (Nivolumab) in Treating Breast Cancer Stem-Like Cells and Drug-Resistant Breast Cancer Mice" @default.
• W4221011736 cites W1499841120 @default.
• W4221011736 cites W1996969161 @default.
• W4221011736 cites W2004039943 @default.
• W4221011736 cites W2004099683 @default.
• W4221011736 cites W2013906202 @default.
• W4221011736 cites W2028487240 @default.
• W4221011736 cites W2038188136 @default.
• W4221011736 cites W2061142153 @default.
• W4221011736 cites W2096768863 @default.
• W4221011736 cites W2107277218 @default.
• W4221011736 cites W2108987447 @default.
• W4221011736 cites W2112601576 @default.
• W4221011736 cites W2115623481 @default.
• W4221011736 cites W2132488145 @default.
• W4221011736 cites W2142721942 @default.
• W4221011736 cites W2157145674 @default.
• W4221011736 cites W2192080449 @default.
• W4221011736 cites W2237148396 @default.
• W4221011736 cites W2269332562 @default.
• W4221011736 cites W2297970061 @default.
• W4221011736 cites W2359219670 @default.
• W4221011736 cites W2512550061 @default.
• W4221011736 cites W2537413785 @default.
• W4221011736 cites W2593766333 @default.
• W4221011736 cites W2598942678 @default.
• W4221011736 cites W2600285053 @default.
• W4221011736 cites W2740527389 @default.
• W4221011736 cites W2744067212 @default.
• W4221011736 cites W2745285076 @default.
• W4221011736 cites W2746944156 @default.
• W4221011736 cites W2766422397 @default.
• W4221011736 cites W2766988166 @default.
• W4221011736 cites W2775645366 @default.
• W4221011736 cites W2778585441 @default.
• W4221011736 cites W2790230298 @default.
• W4221011736 cites W2884390993 @default.
• W4221011736 cites W2888944160 @default.
• W4221011736 cites W2889646458 @default.
• W4221011736 cites W2907897113 @default.
• W4221011736 cites W2909046375 @default.
• W4221011736 cites W2910068212 @default.
• W4221011736 cites W2911909558 @default.
• W4221011736 cites W2955930479 @default.
• W4221011736 cites W2971589893 @default.
• W4221011736 cites W2999133088 @default.
• W4221011736 cites W3033054588 @default.
• W4221011736 cites W3216884219 @default.
• W4221011736 cites W4211032970 @default.
• W4221011736 doi "https://doi.org/10.3389/fonc.2022.781093" @default.
• W4221011736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35402219" @default.
• W4221011736 hasPublicationYear "2022" @default.
• W4221011736 type Work @default.
• W4221011736 citedByCount "1" @default.
• W4221011736 crossrefType "journal-article" @default.
• W4221011736 hasAuthorship W4221011736A5029225084 @default.
• W4221011736 hasAuthorship W4221011736A5031610830 @default.
• W4221011736 hasAuthorship W4221011736A5033990407 @default.
• W4221011736 hasAuthorship W4221011736A5044137903 @default.
• W4221011736 hasAuthorship W4221011736A5053204257 @default.
• W4221011736 hasBestOaLocation W42210117361 @default.
• W4221011736 hasConcept C104317684 @default.
• W4221011736 hasConcept C121608353 @default.
• W4221011736 hasConcept C126322002 @default.
• W4221011736 hasConcept C154317977 @default.
• W4221011736 hasConcept C202751555 @default.
• W4221011736 hasConcept C203014093 @default.
• W4221011736 hasConcept C2777701055 @default.
• W4221011736 hasConcept C2777933648 @default.
• W4221011736 hasConcept C2780030458 @default.
• W4221011736 hasConcept C502942594 @default.
• W4221011736 hasConcept C530470458 @default.
• W4221011736 hasConcept C55427017 @default.
• W4221011736 hasConcept C55493867 @default.
• W4221011736 hasConcept C71924100 @default.
• W4221011736 hasConcept C86339819 @default.
• W4221011736 hasConcept C86803240 @default.
• W4221011736 hasConceptScore W4221011736C104317684 @default.
• W4221011736 hasConceptScore W4221011736C121608353 @default.
• W4221011736 hasConceptScore W4221011736C126322002 @default.
• W4221011736 hasConceptScore W4221011736C154317977 @default.
• W4221011736 hasConceptScore W4221011736C202751555 @default.
• W4221011736 hasConceptScore W4221011736C203014093 @default.
• W4221011736 hasConceptScore W4221011736C2777701055 @default.
• W4221011736 hasConceptScore W4221011736C2777933648 @default.
• W4221011736 hasConceptScore W4221011736C2780030458 @default.
• W4221011736 hasConceptScore W4221011736C502942594 @default.
• W4221011736 hasConceptScore W4221011736C530470458 @default.
• W4221011736 hasConceptScore W4221011736C55427017 @default.
• W4221011736 hasConceptScore W4221011736C55493867 @default.
• W4221011736 hasConceptScore W4221011736C71924100 @default.

• next