Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221018545> ?p ?o ?g. }
- W4221018545 abstract "Mitochondrial mutations are increasingly recognised as informative endogenous genetic markers that can be used to reconstruct cellular clonal structure using single-cell RNA or DNA sequencing data. However, identifying informative mtDNA variants in noisy and sparse single-cell sequencing data is still challenging with few computation methods available. Here we present an open source computational tool MQuad that accurately calls clonally informative mtDNA variants in a population of single cells, and an analysis suite for complete clonality inference, based on single cell RNA, DNA or ATAC sequencing data. Through a variety of simulated and experimental single cell sequencing data, we showed that MQuad can identify mitochondrial variants with both high sensitivity and specificity, outperforming existing methods by a large extent. Furthermore, we demonstrate its wide applicability in different single cell sequencing protocols, particularly in complementing single-nucleotide and copy-number variations to extract finer clonal resolution." @default.
- W4221018545 created "2022-04-03" @default.
- W4221018545 creator A5028008500 @default.
- W4221018545 creator A5043497832 @default.
- W4221018545 creator A5046412520 @default.
- W4221018545 creator A5051982284 @default.
- W4221018545 creator A5065181702 @default.
- W4221018545 creator A5067027448 @default.
- W4221018545 date "2022-03-08" @default.
- W4221018545 modified "2023-10-15" @default.
- W4221018545 title "MQuad enables clonal substructure discovery using single cell mitochondrial variants" @default.
- W4221018545 cites W1573937463 @default.
- W4221018545 cites W2010457001 @default.
- W4221018545 cites W2019552331 @default.
- W4221018545 cites W2036140173 @default.
- W4221018545 cites W2042166975 @default.
- W4221018545 cites W2062199288 @default.
- W4221018545 cites W2081098333 @default.
- W4221018545 cites W2097749765 @default.
- W4221018545 cites W2114104545 @default.
- W4221018545 cites W2146512944 @default.
- W4221018545 cites W2169456326 @default.
- W4221018545 cites W2179438025 @default.
- W4221018545 cites W2338882301 @default.
- W4221018545 cites W2342423616 @default.
- W4221018545 cites W2346273585 @default.
- W4221018545 cites W2418024629 @default.
- W4221018545 cites W2558624268 @default.
- W4221018545 cites W2559249261 @default.
- W4221018545 cites W2567385366 @default.
- W4221018545 cites W2588969809 @default.
- W4221018545 cites W2800852522 @default.
- W4221018545 cites W2802053370 @default.
- W4221018545 cites W2919632356 @default.
- W4221018545 cites W2940982798 @default.
- W4221018545 cites W2942298442 @default.
- W4221018545 cites W2949177718 @default.
- W4221018545 cites W2950304818 @default.
- W4221018545 cites W2952148401 @default.
- W4221018545 cites W2983564869 @default.
- W4221018545 cites W2995043840 @default.
- W4221018545 cites W2997123690 @default.
- W4221018545 cites W3005127469 @default.
- W4221018545 cites W3010981820 @default.
- W4221018545 cites W3011619834 @default.
- W4221018545 cites W3048598023 @default.
- W4221018545 cites W3082136743 @default.
- W4221018545 cites W3097629227 @default.
- W4221018545 cites W3123988232 @default.
- W4221018545 cites W3133716805 @default.
- W4221018545 cites W3134752826 @default.
- W4221018545 cites W3135181104 @default.
- W4221018545 cites W3157353881 @default.
- W4221018545 cites W3194049481 @default.
- W4221018545 cites W3194054041 @default.
- W4221018545 cites W3195445434 @default.
- W4221018545 cites W3197212023 @default.
- W4221018545 cites W4213457742 @default.
- W4221018545 doi "https://doi.org/10.1038/s41467-022-28845-0" @default.
- W4221018545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35260582" @default.
- W4221018545 hasPublicationYear "2022" @default.
- W4221018545 type Work @default.
- W4221018545 citedByCount "6" @default.
- W4221018545 countsByYear W42210185452022 @default.
- W4221018545 countsByYear W42210185452023 @default.
- W4221018545 crossrefType "journal-article" @default.
- W4221018545 hasAuthorship W4221018545A5028008500 @default.
- W4221018545 hasAuthorship W4221018545A5043497832 @default.
- W4221018545 hasAuthorship W4221018545A5046412520 @default.
- W4221018545 hasAuthorship W4221018545A5051982284 @default.
- W4221018545 hasAuthorship W4221018545A5065181702 @default.
- W4221018545 hasAuthorship W4221018545A5067027448 @default.
- W4221018545 hasBestOaLocation W42210185451 @default.
- W4221018545 hasConcept C104317684 @default.
- W4221018545 hasConcept C144024400 @default.
- W4221018545 hasConcept C1491633281 @default.
- W4221018545 hasConcept C149923435 @default.
- W4221018545 hasConcept C16671776 @default.
- W4221018545 hasConcept C174749747 @default.
- W4221018545 hasConcept C24586158 @default.
- W4221018545 hasConcept C2776950831 @default.
- W4221018545 hasConcept C2908647359 @default.
- W4221018545 hasConcept C501734568 @default.
- W4221018545 hasConcept C51679486 @default.
- W4221018545 hasConcept C54355233 @default.
- W4221018545 hasConcept C552990157 @default.
- W4221018545 hasConcept C70721500 @default.
- W4221018545 hasConcept C86803240 @default.
- W4221018545 hasConceptScore W4221018545C104317684 @default.
- W4221018545 hasConceptScore W4221018545C144024400 @default.
- W4221018545 hasConceptScore W4221018545C1491633281 @default.
- W4221018545 hasConceptScore W4221018545C149923435 @default.
- W4221018545 hasConceptScore W4221018545C16671776 @default.
- W4221018545 hasConceptScore W4221018545C174749747 @default.
- W4221018545 hasConceptScore W4221018545C24586158 @default.
- W4221018545 hasConceptScore W4221018545C2776950831 @default.
- W4221018545 hasConceptScore W4221018545C2908647359 @default.
- W4221018545 hasConceptScore W4221018545C501734568 @default.
- W4221018545 hasConceptScore W4221018545C51679486 @default.
- W4221018545 hasConceptScore W4221018545C54355233 @default.