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- W4221019358 endingPage "483" @default.
- W4221019358 startingPage "483" @default.
- W4221019358 abstract "Ghrelin, a hormone produced and secreted from the stomach, is prim arily known as an appetite stimulant. Recently, it has emerged as a potential regulator/biomarker of cancer progression. Inconsistent results on this subject make this body of literature difficult to interpret. Here, we attempt to identify commonalities in the relationships between ghrelin and various cancers, and summarize important considerations for future research. The main players in the ghrelin family axis are unacylated ghrelin (UAG), acylated ghrelin (AG), the enzyme ghrelin O-acyltransferase (GOAT), and the growth hormone secretagogue receptor (GHSR). GOAT is responsible for the acylation of ghrelin, after which ghrelin can bind to the functional ghrelin receptor GHSR-1a to initiate the activation cascade. Splice variants of ghrelin also exist, with the most prominent being In1-ghrelin. In this review, we focus primarily on the potential of In1-ghrelin as a biomarker for cancer progression, the unique characteristics of UAG and AG, the importance of the two known receptor variants GHSR-1a and 1b, as well as the possible mechanisms through which the ghrelin axis acts. Further understanding of the role of the ghrelin axis in tumor cell proliferation could lead to the development of novel therapeutic approaches for various cancers." @default.
- W4221019358 created "2022-04-03" @default.
- W4221019358 creator A5003846107 @default.
- W4221019358 creator A5040093855 @default.
- W4221019358 creator A5041192768 @default.
- W4221019358 creator A5063955906 @default.
- W4221019358 creator A5065402796 @default.
- W4221019358 date "2022-03-22" @default.
- W4221019358 modified "2023-10-01" @default.
- W4221019358 title "Ghrelin and Cancer: Examining the Roles of the Ghrelin Axis in Tumor Growth and Progression" @default.
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